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Showing 1 results for Mirzayan Shanjani
Vajihe Varzandeh, Yaser Kazemzadeh , Sanaz Mirzayan Shanjani , Hossein Shirvani ,
Volume 27, Issue 4 (12-2025)
Abstract
Background and Objective: The beta-catenin (β-catenin) and T-cell factor 1 (TCF1) genes play a crucial role in bone development and remodeling. This study was conducted to determine the effect of combined resistance-aerobic exercise training on the Wnt/β-catenin signaling pathway and bone remodeling in a rat model of aging.
Methods: In this experimental study, 16 aged male Wistar rats (22 months old, weighing approximately 300–350 g) were randomly assigned to two groups: Control and training (n = 8 per group). Additionally, 8 young male rats (3 months old, weighing approximately 190–230 g) were included as a young control group. The training program consisted of eight weeks of combined resistance-aerobic exercise training program, with five sessions per week. Forty-eight hours after the final training session, the rats were anesthetized via intraperitoneal injection of ketamine and xylazine and subsequently sacrificed. Femoral bone tissue samples were isolated under sterile conditions. The expression levels of the target genes were evaluated using the real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) method.
Results: Following eight weeks of combined resistance-aerobic exercise training, a statistically significant increase was observed in the expression of β-catenin and TCF1 genes compared to the aged group (P<0.05). Specifically, the expression levels of β-catenin and TCF1 genes in the aged training group demonstrated a significant statistical increase compared to the aged control group (P<0.05).
Conclusion: Performing combined resistance-aerobic exercise training for eight weeks resulted in a significant increase in the expression of β-catenin and TCF1 genes within the bone tissue of aged rats.
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