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Background and Objective: Coronary heart disease (CAD) is one of the most important causes of death in most countries including Iran. Exercise training after coronary artery bypass grafting and the resulting adaptations increase the capillary density of skeletal and cardiac muscle along with the development of new capillaries and improve cardiovascular and functional ability due to increased mitochondrial biogenesis. This study was done to evaluate the effect of aerobic-resistance training on plasma levels of PGC1α (Peroxisome proliferator 1a) in post coronary artery bypass grafting (CABG) patients.
Methods: This clinical trial study was done on 30 male patients aged 45-60 years who underwent bypass surgery. The patients were randomly divided into intervention and control groups, respectively. Subjects in interventional group were received aerobic resistance training for eight weeks (3 sessions per week). Subjects in control group did not receive any intervention. To measure lymphocytes, fasting blood samples were taken 48 hours prior to the bigning of the first training session and also 48 hours after the last training session. PGC1α was measured using ELISA method.
Results: Aerobic-resistance training caused a significant increase in plasma level of PGC1α in the training group compared to the control group (P<0.05). In intervention group, plasma level of PGC1α was significantly higher after the exercise than before the exercise (P<0.05).
Conclusion: Aerobic-resistance training exercise with increasing serum levels of PGC1α can play a role as an effective factor in initiating angiogenic processes and increasing capillary density and be used as an effective factor in various people, especially cardiovascular patients.

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Background and Objective: Exercise in cardiac patients after coronary artery bypass grafting (CABG) improves cardiovascular function by increasing the capillary density of the myocardium. Platelet-derived growth factor and stromal cell-derived factor-1 play an important role in angiogenesis and cell proliferation and differentiation. This study was performed to determine the effect of eight weeks of combined training on plasma levels of Platelet-derived growth factor (PDGF) and stromal cell-derived factor-1 (SDF1) in CABG patients.
Methods: In this clinical trial study, 24 patients who underwent coronary artery bypass grafting operation were selected using convenience and purposeful sampling method and randomly divided into two combined training and control groups. Subjects in combined training group were received aerobic and resistance training protocols for eight weeks, three sessions per week. Before and after training program, body composition assessments and blood sampling were performed to measure Platelet-derived growth factor (PDGF) and stromal cell-derived factor-1 (SDF1). ELISA method was used to measure PDGF and SDF1.
Results: The level of PDGF was significantly increased in intervention group in compared to control group (P<0.05). Although the level of SDF1 in the intervention group increased in intervention group in compared to control group; but this increase level of SDF1 was not significant.
Conclusion: This study showed that the eight weeks of combined rehabilitation training can promote desirable physiological adaptations in cardiovascular health by increasing the plasma levels of PDGF.