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Background and Objective: In pathogenesis of beta major thalassemia, tissue damage is occurring due to oxidative stress. The present study was designed to evaluate the effects of vitamin E supplementation on serum Paraoxonase, SOD, GPX enzyme activity and lipid profiles in beta major thalassemia patients. Materials and Methods: In this clinical tiral study, Sixty (25 males, 35 females) beta major thalassemia patients with age≥18 years who had criterias to enter the study, were selected randomely in two groups. The patients in interventional group, vitamin E at a dose of 400 mg/day were given for three months, with no supplementations in control group. The enzyme activities of paraoxonase, SOD, GPX and lipid profiles (LDL-c, HDL-c, triglyceride, total Antixidant Capacity) were measured prior and after 3 months in both case and control groups. Data analyzed by using paired t-test. Results: Significant increases in serum levels of vitamin E, Paraoxonase activity, HDL cholesterol (P<0.001), BMI (P≤0.001) and a significant reduction in GPX activity (P<0.05) were observed in cases compared to controls. Conclusion: The vitamin E supplementation may be useful in reducing oxidative stress and lipid profiles in beta major thalassemic patients.

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Background and Objective: Adiponectin is one of the adiposaitocines which secret from adipose tissue and is very effective in the pathogenesis of obesity and its associated disorders, especially in elderly people who are at risk for cardiovascular disease. This study was carried out to evaluate the effect of eight weeks of endurance and resistance training on adiponectin level, insulin resistance index in inactive elderly men. Methods: In this quasi-experimental study, 24 inactive elderly men were non-randomly divided into interventional and control groups. The combined training included endurance training (with intensity of 60-70% of maximum heart rate reserve) and resistance training (with intensity of 70% one repetition maximum). The training performed 3 times per week (one hour session) for 8 weeks. Results: The eight weeks of combined training increased the adiponectin level in interventional group compared to the controls (P<0.05). Insulin and FBS levels, insulin resistance index, and body fat percentage significantly reduced in interventional group compared to the controls (P<0.05). Conclusion: The eight weeks of combined training increases the adiponectin level and reduces insulin resistance in elderly men.

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Background and Objective: Colorectal cancer can significantly cause physical, psychological and social problems. This study was done to determine the prevalence of anxiety and depression in patients with colorectal cancer in Babol located in north of Iran. Methods: This cross-sectional, analytical study was done on 120 (75 males, 45 females) patients with colorectal cancer which registered in the Babol cancer registry in north of Iran during 2008-12. A questionnaire containing demographic information, aspects of the disease and HADS questionnaire was completed by interviewing to assess anxiety and depression for each patient. Results: The prevalence rate of depression and anxiety in patients was 23.4% and 30.8%, respectively. Gender, residency of rural area, and having comorbidities are related to depression among which location was identified as an independent predictor. Urban residency had 79% less risk of depression than rural residents (95% CI=0.06-0.67, OR=0.21, P<0.009). Gender, resident of rural areas, unemployed, having comorbidities, low income and lack of education were associated with anxiety, among which only education was identified as an independent predictor (95% CI=1.32-13.81, OR=4.27, P<0.015). Conclusion: The prevalence of anxiety and depression in colorectal cancer patients was high in this area. Therefore, interventions are recommended to increase awareness and greater attention to rural women and controlling comorbidities.