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Showing 2 results for Hezarkhani
Bakshandeh Nosrat S (md), Bazrafshan Hr (md), Azarhoush R (md), Hezarkhani Sh (md), Mirkarimi M (md), Mokhtari N (md), Besharat S (md), Ghorbani M (msc),
Volume 12, Issue 2 (7-2010)
Abstract
Background and Objective: Destructive effects of thyroid diseases in pregnancy and fetal frowth is well established subclinical autoimmune thyroid diseases can double the rate of preterm labor, abortion and postpartum thyroiditis. This study was done to compare thyroid function and autoimmunity derangment in goiterous and non-goiterous pregnant women. Materials and Methods: This case – control study was done on 100 healthy and 100 goiterous pregnant women in Dezyani hospital located in Gorgan, Northern Iran during 2005. Five mililiter of blood sample was obtained from each subject to measure thyroid hormones concentration including T3/ T4/ TSH/ T3 RUP and thyroid autoantibodies (Anti Tg/Anti TPO). Thyroid hormone and auto antibodies were measured using IRMA and ELISA techniques. Results: Thyroid volume was enlargel twice and tripl of its orginal size in 34% and 66% goitrious pregnant women respectively. Mean serum TSH in cases and controls were 1.81+/-1.33 microU/ml and 1.84+/-1.4 microU/ml respectively. The mean of Anti TPO and Anti Tg in cases were 373.91+-197.36 U/ml and 248.80+-70.59 U/ml respectively. The same indecs for controls were 79.52+-63.99 U/ml and 248.80+-70.59 U/ml respectively. In pregnant women with goiter 36% had high Anti TPO and 9% had high Anti Tg, but in control group 16% and 4% of controls had elevated Anti TPO and Anti Tg, respectively. Conclusion: According to thyroid function tests there were elevation of antibody in 20% of the healthy subjects and 45% of the goiterous subjects, therefore it is advisable to measure thyriod function tests accompanied with thyriod antibodies in all pergnant women either with or without goiter in order to prevent feto-maternal disorders.
Ebrahim Mehdavi , Sharebeh Hezarkhani , S.mehran Hosseini ,
Volume 20, Issue 1 (3-2018)
Abstract
Background and Objective: Insulin resistance (IR) is common in hypothyroidism. IR is one of risk factors for cardiovascular disease. Insulin clamp is the gold standard method for evaluation of IR but it is not routine in clinical usage. The triglyceride- glucose (TyG) and homeostasis model assessment (HOMA) indices are non-invasive surrogate of IR. This study was done to determine the IR using the TyG and HOMA indices in hypothyroid patients.
Methods: This descriptive-analytic study was done on 23 hypothyroid patients including 15 overt and 8 subclinical hypothyroid patients. All patients were new cases and were matched for age, sex, and high. TSH, FT4, TG, LDL, FBS and fasting plasma insulin level were measured twice at time of diagnosis and after treatment and the changes of TyG and HOMA indices were recorded.
Results: In two groups IR based on HOMA was more than TyG index. IR in overt hypothyroidism based on HOMA index was more than two times in comparison with TyG index at the first time and more than three times (10:3) at the second time. IR in subclinical hypothyroidism based on HOMA index was more than four times in comparison with TyG index at the first time and more than three times (7:2) at the second time. A significant difference was found in IR based on HOMA before and after treatment (P<0.05). There were not any significant differences in IR indices of overt hypothyroidism group.
Conclusion: The eight weeks treatment of hypothyroidism and reducing TSH level is probably having no effect on HOMA and TyG in overt and subclinical hypothyroidism.
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