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Showing 2 results for Heidarie
Kavyanifard S, Heidarieh N, Jamalo F, Alinejad G, Alinejad M, Mohammad Eini A,
Volume 18, Issue 2 (6-2016)
Abstract
Background and Objective: Epilepsy is a common neurological disorder. Plantago major (P.major) is used in traditional medicine due to flovonoids and vitamic C and antioxidant properties. This study was done to evaluate the hydro alcoholic extract of Plantago major L. on pentilentetrazol-induced seizures in male mice.
Methods: In this experimental study, 50 NMRI male mice randomly allocated into control and four experimental groups. Seizures in animals induced by 60 mg/kg/bw of pentilentetrazol (PTZ), interperitoneally. Animals in experimental groups were received 5, 10, 25 and 50 mg/kg/bw of hydro alcoholic extract of Plantago major L. 30 min before each PTZ injection. The animals in control group were received saline, interperitoneally. After treatment, the behavior of animals during 20 minutes and mortality rate were recorded.
Results: Seizure threshold of animals significantly increased in experimental groups which were received 50, 25, 10 mg/kg/bw of P.major extract in comparision with controls (P<0.05). Mortality rate of animals significantly reduced in experimental groups which were received 50, 25, 10 mg/kg/bw of P.major extract in comparision with controls (P<0.05).
Conclusion: The hydro-alcoholic extract of Plantago major L. reduces seizure threshold in pentilentetrazol-induced seizures mice.
Fahimeh Sajedifar , Parvin Ehteshmzadeh , Alireza Heidarie , Sahar Safarzadeh ,
Volume 27, Issue 1 (3-2025)
Abstract
Autism is a neurodevelopmental disorder characterized by deficits in communication skills as one of its most prominent diagnostic criteria, and the initiation of intensive early interventions is a critical determinant in the prognosis of this disorder and the reduction of its severity. This study was conducted to determine the effect of the Parent-Implemented Early Start Denver Model (P-ESDM) interventions in improving communication skills and reducing the severity of symptoms in children with autism. This experimental case report with an A-B design was conducted on 4 children (3 boys and 1 girl) under the age of 60 months diagnosed with autism, who were referred to the Shekoufeha Autism Center in the city of Mahshahr, Iran during 2021. Initially, their parents received training in the P-ESDM interventions through 12 individual, one-hour, weekly sessions. The Autism Treatment Evaluation Checklist (ATEC) was used to assess communication skills, and the Gilliam Autism Rating Scale-Second Edition (GARS-2) was employed to assess autism severity. Assessments were conducted in 7 phases (2 baseline assessments, 3 assessments during the intervention, and 2 follow-up assessments). Data analysis involved descriptive statistics, within-condition and between-condition analyses, and an examination of the percentage of overlapping data (POD) and the percentage of non-overlapping data (PND). The implementation of the P-ESDM training culminated in the decreased mean scores, improved communication challenges, and decreased autism severity scores across all 4 subjects. In the within-condition analysis, the subjects’ communication challenges and autism severity scores exhibited a descending and stable trend. Moreover, in the between-condition analysis, the PND at the baseline and intervention phases was at its maximum (100%), and the POD was at its minimum (0%). The observed changes persisted until the follow-up stage. The findings of this study demonstrated that the implementation of the P-ESDM interventions could significantly reduce communication challenges and the severity of symptoms in children with autism, leading to improvements in their communicative skills.
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