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Anomalous coronary artery origin is a rare clinical entity with varied clinical outcomes ranging from asymptomatic to sudden cardiac death. The incidence of anomalous origin of left coronary artery arising from the right coronary cusp is 0.3-1%. CT angiography is the choice method for coronary anomalies, but often coronary angiography in RAO (right anterior oblique) view shows the coronary course. We present a case that referred to our hospital with post myocardial infarction angina for coronary angiography. A resting 12-lead electrocardiogram showed ST-segment elevation in leads v2, v3, v4. A transthoracic echocardiogram indicated LVEF 25% (Left ventricular ejection fraction), septal akinesia and apical dyskinesia. Coronary Angiography showed an anomalous origin of the left coronary artery from the right coronary cusp and significant stenosis in LAD (left anterior descending) and LCX (left circumflex) arteries with poor run off.

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Background and Objective: Cardiovascular diseases are the most frequent cause of death among hemodialysis patients. Left ventricular hypertrophy and systolic dysfunction are potent predictors of cardiovascular morbidity and mortality in hemodialysis patients. Cardiac troponin T and I are the indices of myocardial cell damage. This study was done to determine the relationship between serum cardiac troponin T and I with left ventricular hypertrophy and systolic dysfunction in hemodialysis patients. Method: In this case-control study, 56 hemodialysis patients were divided into two groups according to echocardiographic findings. The first group included 35 patients with left ventricular hypertrophy as case group and 21 patients without left ventricular hypertrophy as controls. Serum level of cardiac troponin T and I were measured using electro chemiluminscence immune assay. Results: Serum level of cardiac troponin T and I was significantly higher in patients with left ventricular hypertrophy (0.99±0.12 ng/ml and 0.17±0.09 ng/ml, respectively) in comparison with controls (0.37±0.05 ng/ml and 0.13±0.09 ng/ml, respectively) (P<0.05). There was no correlation between serum cardiac troponin T and I level with left ventricular systolic dysfunction. Conclusion: Cardiac troponin I and T do not have any value for the diagnosis of left ventricular systolic dysfunction in hemodialysis patients.

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Background and Objective: Granulocyte colony-stimulating factors (G-CSF) and its receptor express in developing follicles, fetal and reproductive tissues. The serum G-CSF concentration significantly increases during the ovulatory phase in comparison with other phases, so G-CSF may have an important role in ovulation and the early cross-talk between mother and conceptus in both human and animal models. This study was done to evaluate the Effect of exogenous G-CSF on ovulation and pregnancy rate in NMRI mice.

Methods: In this experimental study, 40 mature female and 10 male NMRI mice were randomly allocated into the control and treatment groups. All Ovaries were stimulated with intraperitoneal injections (IP) of 10 IU PMSG and after 48 hour by 10 IU hCG per mouse. The treatment group were recieved G-CSF (50mg/kg i.p.), at the time of PMSG administration, while the control group had the same volume of normal saline instead of G-CSF at the same time. 16-18 hours post-hCG administration, twenty female mice of both groups were sacrificed by cervical dislocation and ovulated oocytes were assessed. On day 16 post coitus, the rest of female mice of both groups were scarificed for withdrawing their fetuses to determine the effect of G-CSF on pregnancy rates.

Results: The ovulation rate in the treatment group (18.5±1.25) were significantly more than that of control (12.1±1.32) (P<0.05). The number of fetuses had no significant difference between control and treatment groups.

Conclusion: This study demonstrated that exogenous G-CSF may affect on folliculogenesis and ovulation but the following pregnancy outcome was not impressed.