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Background and Objective: Physical exercise and nutrition supplements are recommended interventions to reduce cachexia. This study was conducted to determine the effect of resistance training and resveratrol supplementation on muscle regeneration indices of MyoD (myoblast determination protein) and eMHC (embryonic Myosin Heavy Chain) in CT-26 colon cancer mice.
Methods: This experimental study was performed on 20 six-week-old BALB/c mice to which CT-26 tumor was implanted. The mice were divided into four groups of resistance training, resveratrol, combination of resveratrol with resistance training, and control. The resistance training group performed six weeks of progressive resistance training. The resveratrol group received 100 mg/kg resveratrol per day, and the control and resistance training group received the solution of Methyl cellulose through gavage. In gastrocnemius muscle MyoD protein and eMHC level were measured using western blot and ELISA methods, respectively.
Results: eMHC protein in combination of resveratrol with exercise group (4.66±0.25) increased significantly compared to the exercise group (3.46±0.64) (P<0.05). Body weight of mice without tumor (21.50±1.30) in the resistance training group increased significantly compared to other groups (P<0.05). There was no significant difference in the tumor weight of mice and MyoD protein in expermental groups.
Conclusion: Regarding the increasing effect of combination of resveratrol with exercise group compared to resistance training group on eMHC, resveratrol supplementation at higher doses may be recommended along with resistance training to improve muscle regeneration.

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Background and Objective: Factors involved in the formation of thoughts and suicide attempts with the complexity of social interactions and increasing the likelihood of its occurrence in different societies have led to a global effort to control and improve this social problem. Therefore, the present study aimed to investigate the role of personality traits in suicide attempts among patients referred to the emergency departments in Gorgan, Iran.
Methods: This case-control study was carried out on 80 individuals who attempted suicide and 80 healthy people who had been referred to emergency departments in Gorgan (Iran) in 2020. Demographic information was recorded and personality type was determined based on the NEO Personality Inventory.
Results: The prevalence of neurological disorders and previous history of suicide in the person and family of the patients who attempted suicide was significantly higher than that in the control subjects (P<0.05). Neuroticism was significantly more prevalent in patients who attempted suicide (P<0.05), but the tendency to extroversion, conscientiousness, openness and agreeableness in patients who attempted suicide was significantly lower compared with the control group.
Conclusion: Given the role of personality traits, especially neuroticism, in suicide attempts, attention to personality traits on suicidal behavior provides important data for improving the treatment.
 

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Background and Objective: Poisoning is one of the most common reasons for emergency department visits worldwide. Awareness of poisoning patterns helps identify risk factors and enables early diagnosis. In Iran, narcotics are among the main causes of poisoning in children. The current study aimed to determine the prevalence of narcotics-induced poisoning in children under 18 years old referring to the Al-e-Jalil Educational and Therapeutic Center in Aq Qala, Golestan Province.
Methods: This retrospective descriptive study was conducted on 36 children aged 1 month to 18 years (22 boys and 14 girls; mean age: 51.62±36.25 months) referring to the Al-e-Jalil Educational and Therapeutic Center in Aq Qala due to narcotics-induced poisoning from 2020 to 2022. Samples were included in the study using census. Patients’ medical records were reviewed and recorded in a checklist.
Results: The highest poisoning rate stemmed from the consumption of opium (69.4%), followed by methadone (25%). Decreased level of consciousness upon hospital admission was determined to be 66.7%. The interval between poisoning and hospital admission was 5.60±3.86 hours. The mean length of hospital stay was 1.25±0.80 days, and no patients died. Most children were male (61.1%), Turkmen (69.4%), and rural residents (86.1%). The highest cases of poisoning occurred in the summer (36.1%). The most common route of contact was oral (97.2%).
Conclusion: The poisoning rate with opium is higher compared to other narcotics. However, there is strong evidence of increased opium use among young people and some evidence of increased methadone use.
 

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Background and Objective: Most Iranian provinces, including Golestan Province, have achieved the 2015 Sustainable Development Goals (SDGs) for childhood mortality. However, evidence suggests that mortality rates in some population groups within these regions remain high and concerning. This study aimed to determine the childhood mortality rate in the city of Aqqala in Golestan Province, Iran.
Methods: This descriptive study was conducted on 416 cases (243 males, 172 females, 1 ambiguous genitalia) of mortalities among children aged 0-18 years residing in rural and urban areas of the city of Aqqala from 2017 to 2022. All registered mortalities were extracted from the electronic health record system at Golestan University of Medical Sciences. Incomplete records or those with imprecisely documented causes of mortality were excluded from the study. The causes of childhood mortality were categorized based on the International Classification of Diseases (10^th Revision, 2016). Age divisions were regarded as 0-28 days, 1-12 months, 1-2 years, 2-6 years, 6-12 years, and 12-18 years for neonates, infants, toddlers, preschoolers, school-aged children, and adolescents, respectively.
Results: The overall mortality rate was determined to be 2.15 deaths per 1000 live births, with rates of 23.1 per 1000 live births for male children and 10.3 per 1000 live births for female children. This rate decreased from 22.7 deaths per 1000 live births in 2017 to 12.3 deaths in 2022. The neonatal mortality rate was determined to be 32.8 per 1000 live births, and the infant mortality rate was 5.5 deaths per 1000 live births. The primary causes of mortality, in order of frequency, included certain conditions originating in the perinatal period (28.2%), congenital malformations and chromosomal abnormalities (17.2%), and transport-related accidents (12%).
Conclusion: Despite a declining trend in the overall mortality rate of children under 18 years in the city of Aqqala in Golestan Province, the neonatal mortality rate in this region is alarmingly higher than the Iranian average, necessitating attention and appropriate measures for further evaluation and intervention.