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Background and Objective: Polycystic ovarian syndrome (PCOS) is one of the most prevalent (6-10%) endocrine glands disorders among child - bearing women. In addition to the patients, their first degree relatives are exposed to some risk factors such as abnormal lipoproteins. Due to high prevalence PCOS among women and the role of genetic factors in this abnormality, it is necessary to recognize high risk people particularly among first degree relative. Therefore this study was conducted to determine the level of serum lipoproteins in first degree relatives of patients with PCOS. Materials and Methods: This case control study was done on 107 individuals of the first degree relatives of PCOS patients as cases and 107 normal individuals of the first degree of non-PCOS as controls in Shiraz, Iran during 2009. Participants completed a test assessing demographics and blood sample were taken from all participants in order to assay serum lipoproteins including total cholesterol, LDL, HDL and triglyceride. Data was analyzed by means of independent t-test and Fisher's exact test as well as Chi-Square. Results: The means±SD of total cholesterol, HDLc and triglyceride in cases was 191±31.64, 167±4.06 and 191±31.64 mg/dl, respectively. The means±SD of total cholesterol, LDLc and triglyceride in controls was 158.25±18.25, 123±21.33 and 120.42±17.11 mg/dl, respectively. Serum level differences of LDL and triglyceride in cases and controls were significant (P<0.05). The means±SD of HDLc in cases and controls was 40.06±6.95 and 45.9±6.7 mg/dl, respectively (P<0.05). Conclusion: This study showed that the serum level of lipoproteins in the first degree relatives of PCOS patients is significant higher than non-PCOS.

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Background and Objective: There is a genetic background for polycystic ovary syndrome (PCOS). Due to increase metabolic disorders, lipoproteins, impaired glucose tolerance, and hypertension in PCOS patients, this study was done to determine the cardiovascular risk factors in first relative member of patients with polycystic ovarian syndrom in Shiraz, Iran. Materials and Methods: This case - control study was carried out on 107 parents and siblings of women with PCOS as cases and 107 non-PCOS parents and siblings of women as controls in Shiraz, Iran during 2007-08. Demographic characteristic, BMI, obesity and blood pressure were recorded for all subjects. Serum lipoproteins including total cholestrol, triglyceride, LDL, HDL and fasting blood sugar were measured in cases and controls. Data were analyzed using SPSS-16.5, independent t-test, Chi-Square and Kappa tests. Results: 35.3%, 26.5%, 11.76% and 5.8% of fatheres in cases were considered as overweight class I, class II, class III of obesity, respectively when compared to controls. This differecne was significant (P<0.05). Waist –hip ratio in mothers in cases (25.6%) and controls (17.9%) were higher than 0.85. Waist –hip ratio among the sisters in case and control groups were 23.5% and 17.6%, respectively (P<0.05). Hypertension was observed in 12.2% of cases and 3.7% of controls. This difference was not significant. High level of triglyceride were determined in 14.94% of cases and 6.5% of controls. A significant correlation was found between BMI and diabete II in case and control groups (P<0.05). Disorder in glucose tolerance test (GTT) in case and control goups were 19.62% and 7.47%, respectively (P<0.05). The obesity was found in 18.7%, 6.54% in cases and controls with disorder in GTT (P<0.05). Conclusion: This study showed that obesity, central obesity, high level of serum lipoproteins and hypertension among first relative member of patients with PCOS are significantly higher than the controls.