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Background and Objective: Urinary tract infection is the most common bacterial infection during pregnancy. The pregnant women seems to be at risk for pyelonephritis and untreated infection. Timely recognition and on-time appropriate treatment of urinary tract infection particularly in pregnant women reduce the related complications. This study was done to assesse Sensitivity of isolated E.coli from pregnant women urine to antibiotics. Materials and Methods: In this descriptive study E.coli isolated from 360 urine samples from pregnant women, were examined, using Eosin Methylene Blue, blood sugar method. Antibiogram diffusion disk Kirby-Bauer was performed to assess the antibiotic response. Results: The persent of sensitivity of Escherichia coli to antibiotics were Co-amoxiclav (5.72%), Ampicillin (8.86%), Amoxicillin (11.87%), Cefazolin (32.12), Cephalexin (36.1%), Gentamicin (40.28%), Co-trimoxazole (48.15%), Nalidixic acid (55.3%), Nitrofurantoin (72.48%) and Ceftriaxone (80.78%). Conclusion: This study showed that there is a high level of E.coli antibiotics resistance toward Amoxicillin and Ampicillin high sensevity is related to Ceftriaxone and Nitrofurantoin in this region.

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Background and Objective: Pseudomonas aeruginosa is one of the important causes of nosocomial infections. Extended spectrum-beta Lactamases (ESBLs) and Metallo-beta Lactamase (MBL) producing strains have become resistant against a wide range of antibiotics. The aim of this study was to determine the effect of Methanol extract of Camellia Sinensis on Pseudomonas aeruginosa producing ESBL isolated from burnt wounds of patients.

Materials and Methods: This descriptive study was done on burnt wounds of 245 hospitalaized patients in Shafa hospital, Kerman, Iran during 2006-07. ESBLs producing strains were detected by phenotypic confirmatory test and also E-test strips were used for MBL detection. P.aeruginosa MIC was determined for Cefotaxime, Ceftazidime, Azteronam, Imipenem, Meropenem and methanol extracts of plant Camellia Sinensis prepared by Maceration method.

Results: 120 of burnt wound infected with P.aeruginosa, out of them 41 isolates contained ESBL while lacked MBL. 60% of isolates were resistant to Cefotaxime, 66% to Ceftazidime, 42% to Azteronam, 3% to Imipenem and 5% to Meropenem. Among the extracts, green Tea had the highest antibacterial effect on standard strains and P.aeruginosa producing ESBLs in 1.25mg/ml concentration.

Conclusion: This study showed that methanolic extract of green tea has higher antibacterial effect aginst β-lactamase P.aeruginosa strains than Cefotaxime and Ceftazidime.

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Background and Objective: The first effect of stress on the immune system is usually a rapid increase in function which manifests itself by an increase in the number of inflammatory cytokines in blood. It is however, followed by a decrease of function in immunological response. During inflammation, the expression of hepcidin gene is increased in order to keep iron away from pathogens. This study was conducted to determine the effect of chronic mild stress on the expression of hepcidin gene in the hippocampus of the male adult rats. Materials and Methods: This experimental study was carried out on 30 adult male Wistar rats, weighing approximately 200-250 grams. They were randomly allocated into two groups of 15 rats: control and chronic mild stress group. Animals in intervention group were exposed to chronic mild stress for 3 weeks. At the end of the stress protocol, 2 ml blood sample was collected to measure the serum concentration of IL-6. Real time PCR method was used to investigate hepcidin expression in hippocampus. Data were analyzed using SPSS-16 and independent t-test. Results: The mean level of IL-6 was significantly higher in the CMS exposure group (27.98±0.84 pg/ml) than control group (18.29±1.18 pg/ml) (P<0.05). Hepcidin expression in the hippocampus of intervention group was significantly higher (2.69±0.226%) in compared to control group (1±0.105) (P<0.001). Conclusion: This study showed that chronic mild stress increases the expression of hepcidingene and the serum level of IL-6 in adult rats.

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Background and Objective: There are relations between rate of loading, osteoarthritis and genu varum result in osteoarthritis. This study was done to compare the peak vertical ground reaction forces and the rate of loading during single leg drop landing between men with genu varum deformity and normal knee from three heights. Methods: This quasi-experimental studywas carried out on 20 male students with genu varum deformity and 20 male students with normal knee. Genu varum deformity was measured and recorded by collis and goniometer. Subjects performed single-leg landing dropping from three heights (20, 40, 60 Centimeter) on a force platform. Results: The peak vertical ground reaction force in calcaneus contact and the rate of loading between groups significantly were different (P<0.05). No significant difference was found in the peak vertical ground reaction during toe contact. Conclusion: Frontal knee angle affect on loading rate. Maybe one of the reasons for higher injury risk and knee arthritis in genu varum population might be due to higher ground reaction forces and the rate of high loading.

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Background and Objective: Genuvarum is considered as one of the risk factors for the incidence of osteoarthritis. This study was done to compare the knee joint muscles activity during single leg drop landing from different heights among men with genu varum and men with normal knee.

Methods: This case – control study was done on 20 male students with genu varum deformity and 20 male students with normal knee. Genu varum deformity was measured by a kolis and goniometer. Muscle activity of lower limb was recorded with electromyography.

Results: There was significant difference in muscles activity of medialis gastrucnemius, peroneus longus, biceps femoris and gluteus medius in cases and controls (P<0.05), while no significant difference was observed in other muscles.

Conclusion: The changes in the knee normal structure might affect daily activities and possibly lead to in injuries due to physical training.

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Background and Objective: Stiffness and restricted range of movement (ROM) affect muscle balance and body alignment. The purpose of this research is the study the relationship between Iliopsoas tightness and hip active range of motion, extensor-flexor muscle strength and thoracolumbar curves.
Methods: This case-control study was carried out on 15 adolescent's male soccer players with short length of Iliopsoas muscle as case group and 15 healthy adolescents witch matched based on age, height, weight, BMI, dominant leg and sport experience as control group. The range of motion was measured with universal goniometer, kyphosis and lordosis with flexible ruler and muscle strength with manual dynamometer.
Results: The range of motion of the hip extension and the strength of the Iliopsoas muscle in the case group were statistically lower than the control group (P<0.05). The rate of lumbar lordosis and the ratio of gluteus maximus to the strength of the Iliopsoas muscle in the case group were significantly higher than the control group (P<0.05). There was no statistically significant difference between the range of motion of hip flexion, dyspnea kyphosis, and gluteus maximus muscle strength in the studied groups.
Conclusion: Adolescents with Iliopsoas tightness have limited hip extension and greater lumbar lordosis and weaker Iliopsoas strength in comparison to healthy counterparts.

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Background and Objective: The trigger point is the irritable point associated with a tight band of skeletal muscle which is painful against stress and strain. The real goal in treating trigger points is to achieve a degree of pain relief so that the sufferer can return to his usual activities and functions in spite of some pain. This study was carried out to compare of two methods of sports massage and cold stretch on the threshold of pain in passive trigger points in shoulder girdle muscles of the female volleyball players.
Methods: In this quasi-experimental study, 32 females national volleyball palyer who has a latent trigger point in the shoulder girdle region were non-randomly divided into to three groups of sports massage (n=11), stretching along the cold (n=11) and control (n=10) groups. Threshold of pain test was carried out in two steps, prior and immediately after sports massage and stretching along the cold.
Results: The mean of pain threshold prior and immediately after the study in control group was 38.84±11.348 and 35.16±9.311, respectively. The mean of pain threshold prior and immediately after the study in sports massage group was 39.40±9.88 and 43.54±9.63, respectively. This differernce was not significant. The mean of pain threshold prior and immediately after the study in stretching along the cold group was 39.22±10.57 and 41.10±10.95, respectively. This differernce was not significant.
Conclusion: Sports massage and stretching along the cold did not significant effect on the threshold of pain in passive trigger points in shoulder girdle muscles of the female volleyball players.

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Background and Objective: Chronic and recurrent abdominal pain affect about 7-20% of children in school age, and it is responsible for 2-4% of children's medical referrals. Helicobacter pylori infection in children can cause gastrointestinal problems in childhood, and the lack of treatment and eradication can lead to serious complications. This study was done to evaluate the prevalence of Helicobacter pylori ELISA stool antigen in children with chronic abdominal pain.

Methods: In this case control study, 33 children with chronic abdominal pain and 30 normal children were evaluated. The stool was tested by ELISA method to evaluate Helicobacter pylori antigen.

Results: 15.2% of chidern in the chronic abdominal pain group were positive for Helicobacter pylori. No positive case was found among control group. This difference between case and control groups was significant (P<0.05).

Conclusion: Considering the high prevalence of Helicobacter pylori antigen in children with chronic abdominal pain, it is suggested that children with chronic abdominal pain without a definite cause screened for Helicobacter pylori infection.

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Background and Objective: Children with ADHD suffer from motor impairment in addition to behavioral problems (hyperactivity/impulsivity, attention deficit).The cerebellum receives data from visual, vestibular and somato- sensory systems.This study was done to determine the correlation between kinetic parameters of balance performance and behavioral symptoms in children with attention-deficit/hyperactivity disorder.
Methods: This case - control study was performed on 15 children with ADHD (9.21±0.69 year) and 15 healthy children (9.27±0.75 year). Kinetic parameter of balance evaluated using sensory organization test (SOT) in different sensory conditions including visual, somatosensory and vestibular by Neurocom. Conner’s questionnaire used to assess hyperactivity and attention deficit in addition to a psychologist.
Results: Dynamic balance score in ADHD children was significantly lower in compare to controls (p<0.05). Children with ADHD had kinetic parameters of balance performance abnormality in compare to controls. There was a significant correlation between sensory contribution and hyperactivity in children with ADHD (P<0.05).
Conclusion: Children with ADHD suffer from balance dysfunction which is a result of sensory integration and attention deficit. The sensory systems analysis showed that vestibular system, partially somatosensory dysfunction is the most important factor in balance disorder in children with ADHD.

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Background and Objective: One of the most important concerns in children is self- medication that may cause in delay the correct diagnosis, and increases morbidity and mortality. This study was performed to determine the frequency of self-medication of parents in children in need of medical care in Gorgan city.
Methods: This descriptive-analytical study was performed on 270 children referred to the pediatric clinic of Taleghani Hospital in Gorgan, northern Iran during 2018-19. Medications were given to the children by their parents arbitrarily without prescriptions by doctors during the recent week were evaluated.
Results: 58.5% and 41.5% of children were males and females, respectively. The average age of children was 5.79 ±4.15 years. Self-medication was the first choice of 60.4% of parents. In the recent week, 48.9% of parents had self-medicated to treat their child's current illness, of which 31.8% reported antipyretic, 17.4% herbal medicines, 11.4% antibiotics and 23.5% other medicines. 91% of parents were unaware of correct dose of drugs and 96.3% did not have any knowledge about possible side effects of drugs, contraindications and precautions. There was a statistically significant association between parent job (self-employment) and self-medication (P<0.05).
Conclusion: 48.9% of parents were performed self-medication on their children. Out of those parents 91% and 96.3% were not aware from the correct drugs dosage and of possible side effects, contraindications and potential risks respectively.

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Background and Objective: Poisoning is one of the most common causes of emergency room visits. Opioids and methadone are the causes of unintentional poisoning, especially in children, who have a high burden of emergency referrals in children's hospitals. This study was performed to evaluate methadone poisoning in the pediatric emergency department in Gorgan, North of Iran.
Methods: This cross-sectional study was performed on the records of patients admitted (85 boys and 70 girls) cases due to methadone poisoning in Taleghani Hospital in Gorgan, North of Iran during 2001-19 .The symptoms of patients and the costs of treatment and care of patients were analyzed.
Results: A total of 258 cases of poisoning were registered, of which 155 (60%) were methadone poisoning. Poisoning occurred for 136 cases (87.8%) with methadone syrup and for 19 cases (12.2%) with methadone tablets. The mean of age and age range was 47.94±36.25 months and 4-156 months, respectively. The mean and standard deviation of the time interval from consumption to the time of admission was 164.84±160.11 minutes and the maximum and minimum time interval were 720 and 15 minutes, respectively. 34 cases (22%) were conscious, 110 cases (71.5%) had impaired level of consciousness, seven cases (4.5%) presented with cardio respiratory arrest and three patients (1.9%) presented with seizures and one child (0.1%) was dead. Moises, bradypnea and apnea were seen in 78 (51.3%), 62 (40%) and 7 (4.5%) children, respectively. Six children had a history of hospitalization due to methadone poisoning, of which 2 were the day before, 3 were the month before, and 1 was 2 years ago. Two children were addicted. The mean±SD of the number of hospitalization days were 2.39±1.57 and the minimum and the maximum were 1 and 9 days. The mean±SD of hospitalization cost was 7642249±5341725 Rials. The average consumption of naloxone was 6.83± 10.41mg and the minimum and the maximum were one and 68 milligrams.
Conclusion: The results of this study showed that meiosis is not observed in half of children with methadone poisoning. Therefore, it is recommended that in the case of children with impaired level of consciousness or seizures without a specific reason; methadone poisoning should be concerned as a differential diagnosis by medical staff and this diagnosis should not be ignored only in the absence of meiosis or respiratory dysfunction.

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Background and Objective: Silver nanoparticles are produced in large quantities in the industry and have estrogenic activities and toxic effects on different organs. This study was conducted to determine the effect of silver nanoparticles on the ovarian tissue of NMRI rats treated with alpha lipoic acid.
Methods: In this experimental study, 24 female NMRI rats were randomly divided into 4 groups of 6. The groups included the control group, oral silver nanoparticles (500 mg/kg of body weight), injected alpha lipoic acid (100 mg/kg of body weight), and silver nanoparticles (500 mg/kg of body weight) plus alpha lipoic acid (100 mg/kg body weight). The treatment was performed for 28 days. After the treatment period, blood sampling was performed from the rats’ hearts to analyze biochemical parameters (malondialdehyde, estrogen, progesterone, and total antioxidant capacity using the ferric reducing ability of plasma (FRAP) method). By dissecting the rats, the left ovaries were removed, fixed, molded, and cut, tissue passaging was performed, and the ovaries were stained using the hematoxylin-eosin method. Then, the ovarian tissue was evaluated by different stereological methods.
Results: The total mean ovarian volume, the cortex volume, the medulla volume, and the corpus luteum volume, and the total number of primordial, primary, secondary, and Graafian follicles were significantly reduced in the silver nanoparticles group compared to the control group (P<0.05). The simultaneous administration of alpha lipoic acid and silver nanoparticles compensated for the adverse effects of silver nanoparticles on the above parameters. On the other hand, the mean number of different types of follicles in the rats treated with alpha lipoic acid significantly increased compared to the control group (P<0.05). A statistically significant reduction was observed in the measurement of estrogen and progesterone hormones in the serum of the silver nanoparticles group compared to the control group (P<0.05). Moreover, in assessing the antioxidant capacity of the serum of the group treated simultaneously with silver nanoparticles + alpha lipoic acid, a statistically significant increase was observed compared to the group treated with silver nanoparticles (P<0.05).
Conclusion: Silver nanoparticles can have adverse effects on the structure of the ovary and its components, and alpha lipoic acid can largely compensate for these detrimental effects.