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Kikuchi-Fujimoto disease is a necrotizing Lymphadenitis with benign self-limit process in young women with fever, cervical lymphadenopathy and increased ESR with leukopenia. In this report we introduce 2 females with Kikuchi-Fujimoto disease. The first patient was a 31 years old lady with fever and unilateral cervical lymphadenopathy weight loss from 20 days age. In paraclinical findings ESR=50 mm/hr Hb=10 gr/dl. WBC count was 5300/µl bone marrow aspiration and biopsy with lymph node was done. The histopathologic diagnosis was Kikuchi-Fujimoto (Necrotizing Lymphadenitis). The 2nd patient was a lady with 35 years old and painful neck mass (Behind the sterno-clido mastoid) from 1.5-month age with fever and chill. In paraclinical findings ESR=52 mm/hr WBC 5500/µl, CRP++ lymph node biopsy was done the histopathologic diagnosis was Kikuchi-Fujimoto necrotizing Lymphadenitis. Therefore Kikuchi disease is a important differential diagnosis in young patients especially women with cervical lymphadenopathy and fever (FUO).

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Background and Objective: Resveratrol is a phenolic herbal compound which has been proposed as antioxidant in combinational therapy of diabetes, cancer and some neurodegenerative diseases. This study was done to evaluate additive effect of trans-resveratrol and imipramine to reduce depressive symptoms in the forced swimming test in mice.

Methods: In this experimental study, 56 Swiss Webster male mice were randomly allocated into 6 groups including negative control group (normal saline), positive control (imipramine (10 mg/kg/bw), experimental groups; trans resveratrol (10 mg/kg/bw), Imipiramine (10 mg/kg/bw) and mixtures (with ratio of 1:1 of resveratrol with imipramine (2.5 mg/kg/bw, 5 and 10 mg/kg/bw), intraperitoneally. The forced swimming test has been done for all groups. Through swimming of animals in water, the immobilization times of animals as depressive symptom were recorded.

Results: The immobilization times significantly reduced in animals which were received imipramine
10 mg/kg/bw in compare to control group (P<0.05). The immobilization times of animals were received resveratrol injection 10 mg/kg/bw with imipramine 10 mg/kg/bw was determined which it was significantly effective than imipramine10 mg/kg/bw, alone (P<0.05). The antidepressant effectiveness of resveratrol injection 5 mg/kg/bw is similar to resveratrol (2.5 mg/kg/bw) with imipramine (2.5mg/kg/bw). is similar to resveratrol (2.5 mg/kg) with imipramine (2.5 mg/kg/bw) (P<0.05). Also, antidepressant effect of intraperitoneal administration of resveratrol 10 mg/kg was significantly more than imipramine
10 mg/kg/bw (P<0.05).

Conclusion: According to additive effect of imipramine with resveratrol we can suggest resveratrol in combinations with other antidepressants to lower their doses and related side effects of chemical drugs.