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Background & Objective: Pityriasis rosea is an acute inflammatory dermatosis with an unknown cause. Although it is a self limitted disorder and has no chronic side effects (nevertheless it will take between 3-6 weeks) but it may continue for two months. In order to shorten pityriasis rosea course and remove itching and skin lesions, it is advisable to cure the disease with an appropriate drug. Based on the above, the present study was performed to investigate efficacy of Erythromycin in comparison with placebo and improve this disease period. Materials & Methods: A randomized double blind clinical trail was carried out on typical pityriasis rosea patients who had referred to 5th Azar clinic Gorgan-Iran during December 2004-May 2005. 46 patients were selected and randomly divided into two groups (23 patients in each one). Since it was a double blind study, treatment for two weeks was prescribed then the cure rate was measured during second, fourth and sixth week. In case group, Erythromycin 1gr/day was prescribed and continued for two weeks. In the other group only placebo was prescribed. Statistical analysis: Pearson chi-square analysis with 2- sided p value was applied to compare the distribution of pityriasis rosea between patients by using Sspss-11.5 software Regard to the kind of study and qualitative attribute, we used comparison between ratios in order to analyze them. Meaningful level for these tests was α=0.05. Results: Even though we gained good results in case group during second, fourth and sixth week after treatment, but there was no significant difference between these two groups at α=0.05. Conclusion: This investigation shows that Erythromycin has little effect on pityriasis rosea period. Therefore we suggest complementary study with larger samples in future.

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Granuloma faciale is an uncommon cutaneous lesion characterized by asymptomatic skin nodules and plaques without any systemic presentation. The lesions mainly seen in middle aged males. We report an uncommon presentation (multiple cutaneous lesions) in trunk,upper arm and face)of a 32 years old male.

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Background and Objective: Understanding the cellular signaling mechanisms involved in muscle hypertrophy is considered a scientific challenge. Mammalian target of rapamycin (mTOR) is one of the regulatory factors in this process that increases protein synthesis in skeletal muscle through phosphorylation. This study aimed to determine the effect of six weeks of high-intensity interval training (HIIT) on phosphorylated mTOR protein in the quadriceps muscles of adult male Wistar rats.
Methods: In this experimental study, 16 adult male Wistar rats (six weeks old and weighing an average of 190.93±4.97g) were used. The animals were randomly divided into two groups of control and training (n=8). The training group underwent six weeks of HIIT on a treadmill, with five sessions per week. The load was increased during the six weeks from repeating the interval of 30 meters per minute for 30 seconds in the first sessions to eleven repetitions of the interval of 35 meters per minute for 30 seconds at the end of the sixth week, with rest intervals between the intervals at a speed of 13 meters per minute for 60 seconds. The control group did not undergo any training. The mice were anesthetized, and the Vastus lateralis of the quadriceps muscle was extracted. The level of phosphorylated mTOR protein in the quadriceps muscle was measured using the immunohistochemical method.
Results: HIIT significantly increased the levels of mTOR phosphorylation protein in male Wistar quadriceps femoris muscle compared to the control group (P<0.05).
Conclusion: Interval activity can have a positive effect on muscle hypertrophy through mTOR.