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Background and Objective: Lichen planus presents with chronic, inflammatory mucocutaneous lesions with almost 1-2% prevalency without any relation to demographic variables. This study was done to describe the clinical pathologic features of lichen planus patients in Mashhad, Iran. Materials and Methods: In this descriptive study, demographic data (age and sex) and some factors such as histology, form and anatomical zone of lesions were recruited from patient’s medical records and pathological slides revised. Data analyzed by using SPSS-13 software and chi-square and T student tests. Results: 309 patients (177 male, 132 female) were enrolled. Mean age was 40.12±16.3 years-old and patients were categorized mostly in 41-50 years age group. Clinical presentation in 44% was plaque and 41.7% with papules, 23.9% hyper pigmented, 26.9% scaled, 4.9% annular form and 2.9% linear. 45.6% of patients had classic histo-morphology and 25.9% of them had hypertrophic form. There was not any relationship between lesion histopathology with either sex or age. Anatomical zone had a significant relation with histopathology of lesion (P<0.05). Conclusion: This study showed that the prevalence of genital and mucousal lesions was lower than reported in other studies in various parts of the world.

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Background and Objective: Tinea versicolor is a common fungal infection of the skin caused by the dimorphic lipophilic yeast Pityrosporum orbicular (Malassezia furfur). Lesions begin as multiple small, circular macules of various colors. The upper trunk is most commonly affected due to the side effects of oral treatment and drug resistance, this study was done to compare the therapeutic efficacy of topical terbinafine versus topical ketoconazole in Tinea versicolor. Materials and Methods: This Randomized double blind clinical trial study was conducted between 2008-09. Sixty nine patients with a clinical diagnosis of pityriasis versicolor confirmed by microscopic potassium hydroxide (KOH) examination were taken for the study. Patients randomly divided into 2 treatment groups: 35 patients in terbinafine group, treated by terbinafine 1% once daily for 2 weeks and 34 patients in ketoconazole group, treated with ketoconazole 2% once daily for 2 weeks. Five patients of terbinafine and 4 patients of ketoconazole groups were excluded due to lack of follow-up. Patients were followed up at monthly intervals for 3 months and recurrence and cure rate for each subject were recorded. Data was analyzed by SPSS-16, t student and Chi-Square test. Results: The mean moderate cure rate obtained one month after treatment was 20% in terbinafine group versus 3.3% in ketoconazole group, and there was no any significant difference between two groups. The mean moderate cure rate two month after treatment was 67.7% in terbinafine group and 60% in ketoconazole group (P<0.05). The mean complete cure rate three month after treatment was 73.3% in terbinafine group and 10% in ketoconazole group (P<0.05). The percent of positive KOH examination, three month after treatment was 10% in terbinafine group and 36.7% in ketoconazole group (P<0.05). Conclusion: This study showed that terbinafin is more effective than ketoconazole in treatment of tinea versicolor.

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Background and Objective: Superficial pigmented lesions are the most common complaint in dermatology. This study was done to assess the therapeutic effect of cryotherapy in facial lentigo and junctional nevus. Materials and Methods: In this descriptive study, 100 cases of flat-pigmented lesions with diameters up to 2 mm and after taking a photograph with USB microscope M2 (Scalar) treated with one freeze thaw cycle with liquid nitrogen through an applicator for 2 second in Imam Reza hospital, Mashhad, Iran during 2004-05. The patients were visited 3 times again through 3 successive months. According to the decrease in color of the lesion, patients were divided into 4 groups: sever pigmentation, no response, partial (>50% color loss) and complete response (<50% color loss). Data were analyzed using SPSS-11.5 and Wilcoxon test. Results: 96% of our patients were female and 4% were male. Mean age was 30±11.7 years. Based on Fitzpatrick criteria fifteen patients had type 2, fifty had type 3 and 35 had type 4 skin color. After the period of 3 months follow up, 6% of the patients completely healded, 58% had partial response, 31%with no response and 5% develop hyperpigmentation. Response in patients with type 2 Fitzpatrick skin color was clinically better than type 3 and 4 but this difference was not significant. Conclusion: Cryotherapy is considered as a simple, cost effective and safe therapeutic regiment in treating of 64% facial pigmental lesions.

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Background and Objective: Burn is one of the leading causes of mortality in the world. This study was done to determine the effect of the lavender, sesame oil, and combination of Lavender with sesame oil and silver sulfadiazine on the burn wound healing in mice.
Methods: In this experimental study, 30 male adult albino mice were randomly allocated into 5 groups as follows: the negative control group (physiology serum); the positive control group (silver sulfadiazine); the first experimental group (sesame oil), the second experimental group (combination of Lavender with sesame oil) and the third experimental group (Lavender oil).Second degree of  burn wound healing  take place using hot sheet with a diameter of 2 cm. wound treatment was done in five groups in 21-day treatment period. The wound diameter size and restoration percentage were measured on days 1, 3, 6, 9, 18, and 21. Some mice were euthanized and the samples of wounds were used for histopathological studies.
Results: The percentage of wound healing significantly increased in groups of silver sulfadiazine, combination of Lavender with sesame oil, Lavender oil and  sesame oil in compared to control group (P<0.05). The improvement percentage was seen in sulfadiazine and combination of Lavender with sesame oil groups in compared to negative control group. The level of tissue restoration based on the accumulation of collagen, fibroblasts, re-epithelialization were seen in sulfadiazine, combination of Lavender with sesame oil, Lavender oil and sesame oil, respectively.
Conclusion: Combination of Lavender with sesame oil similar to silver sulfadiazine has tissue restoration effect on burn wound healing in animal model.