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:: Volume 24, Issue 3 (10-2022) ::
J Gorgan Univ Med Sci 2022, 24(3): 1-7 Back to browse issues page
Effect of Vitamin D on Lung Function, Serum Immunoglobulin E and Total Antioxidant Capacity in Asthma Patients: A Clinical Trial
Sayyed Gholamreza Mortazavi Moghaddam1 , Asghar Zarban2 , Ali Mirshahi 3
1- Assistant Professor of Internal Medicine, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
2- Professor of Biochemistry, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
3- Internist, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran. , oabstudent@gmail.com
Abstract:   (827 Views)
Background and Objective: Asthma is a chronic airway disorder with a rising prevalence. Dietary factors, antioxidant indicators and vitamin D deficiency are associated with the disease. Due to the presence of receptors for this vitamin in the lung, this study aimed to investigate the effects of vitamin D administration on lung function, serum immunoglobulin E (IgE) level and total serum antioxidant activity in patients with moderate to severe asthma.
Methods: In this clinical trial, 60 patients with asthma were randomly divided into two groups: a control group (placebo recipient) and an intervention group (recipient of 2,000 vitamin D capsules for 12 weeks). At the beginning and at the end of the study, 5 cc blood samples were taken from each patient, and spirometry test was performed. Total antioxidant capacity (TAC), IgE and vitamin D parameters were measured.
Results: The mean score of forced expiratory volume (FEV1) and FEV1/FVC in both groups as well as the mean FVC in the control group did not change significantly after the intervention. The mean FVC score, vitamin D level and TAC in the intervention group increased significantly after the intervention, while the IgE levels reduced significantly.
Conclusion: Taking vitamin D tablets could increase the antioxidant parameters in asthmatic patients.
 
Keywords: Asthma [MeSH], Vitamin D [MeSH], Immunoglobulin E [MeSH]
Article ID: Vol24-29
Full-Text [PDF 786 kb]   (5831 Downloads)    
Type of Study: Original Articles | Subject: Internal Medicine
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Mortazavi Moghaddam S G, Zarban A, Mirshahi A. Effect of Vitamin D on Lung Function, Serum Immunoglobulin E and Total Antioxidant Capacity in Asthma Patients: A Clinical Trial. J Gorgan Univ Med Sci 2022; 24 (3) :1-7
URL: http://goums.ac.ir/journal/article-1-4040-en.html


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Volume 24, Issue 3 (10-2022) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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