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Effect of aerobic-resistance training on plasma level of Peroxisome proliferator 1α in patients after coronary artery bypass grafting: A clinical trial study
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Azar Hamidi1    , Amir Rashid Lamir 2, Rambod Khajei3 , Mehdi Zarei4 , Ahmad Zendeded5 |
1- Ph.D Candidate in Sport Physiology, Department of Physical Education and Sport Sciences, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran.
2- Associate Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran. , rashidlamir@um.ac.ir
3- Assistant Professor, Department of Physical Education and Sport Sciences, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran.
4- Assistant Professor, Department of Physical Education and Sport Science, Faculty of Human Sciences, University of Neyshabur, Neyshabur, Iran.
5- Ph.D in Statistics, Associate Professor, Department of Mathematics, Faculty of Basic Sciences, Neyshabour Branch, Islamic Azad University, Neyshabour, Iran. |
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Abstract: (5731 Views) |
Background and Objective: Coronary heart disease (CAD) is one of the most important causes of death in most countries including Iran. Exercise training after coronary artery bypass grafting and the resulting adaptations increase the capillary density of skeletal and cardiac muscle along with the development of new capillaries and improve cardiovascular and functional ability due to increased mitochondrial biogenesis. This study was done to evaluate the effect of aerobic-resistance training on plasma levels of PGC1α (Peroxisome proliferator 1a) in post coronary artery bypass grafting (CABG) patients.
Methods: This clinical trial study was done on 30 male patients aged 45-60 years who underwent bypass surgery. The patients were randomly divided into intervention and control groups, respectively. Subjects in interventional group were received aerobic resistance training for eight weeks (3 sessions per week). Subjects in control group did not receive any intervention. To measure lymphocytes, fasting blood samples were taken 48 hours prior to the bigning of the first training session and also 48 hours after the last training session. PGC1α was measured using ELISA method.
Results: Aerobic-resistance training caused a significant increase in plasma level of PGC1α in the training group compared to the control group (P<0.05). In intervention group, plasma level of PGC1α was significantly higher after the exercise than before the exercise (P<0.05).
Conclusion: Aerobic-resistance training exercise with increasing serum levels of PGC1α can play a role as an effective factor in initiating angiogenic processes and increasing capillary density and be used as an effective factor in various people, especially cardiovascular patients.
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Keywords: Coronary Artery Bypass [MeSH], Exercise [MeSH], Peroxisome proliferator 1α [MeSH]
Article ID: Vol23-19 |
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Full-Text [PDF 1043 kb]
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Type of Study: Original Articles |
Subject:
Exercise Physiology
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Hamidi A, Rashid Lamir A, Khajei R, Zarei M, Zendeded A. Effect of aerobic-resistance training on plasma level of Peroxisome proliferator 1α in patients after coronary artery bypass grafting: A clinical trial study. J Gorgan Univ Med Sci 2021; 23 (2) :1-7 URL: http://goums.ac.ir/journal/article-1-3730-en.html
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