[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
About the Journal
Aim and Scope
Content Coverage
Ethics
Conflict of Interest
Copyrights & License
Price
Indexing Sources::
Editorial Board::
Executive Members::
Articles Archive::
Current Issue
All Issues
Instruction to Authors::
Peer-Review::
Contact Us::
Contact Us
Contact Form
Site Facilities::
Search contents
::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 20, Issue 1 (3-2018) ::
J Gorgan Univ Med Sci 2018, 20(1): 36-42 Back to browse issues page
Effect of donepezil hydrochloride on reference and working memory impairment after bilateral electrical lesion of nucleus basalis magnocellularis in rats model of Alzheimer disease
Azade Eskandary1 , Ahmad Ali Moazedi 2, Hossein Najaphzadevarzi3 , Mohamad Reza Akhond4
1- Ph.D Candidate in Animal Physiology, Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2- Professor, Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran. moazedi.a@gmail.com , moazedi.a@gmail.com
3- Professor, Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Professor, Department of Pharmacology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
4- Assistant Professor, Department of Statistics, Faculty of Mathematical Sciences and Computer, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Keywords: Alzheimer disease, Nucleus Basalis Magnocellularis, Memory, Donepezil hydrochloride, Rat
Full-Text [PDF 294 kb] [English Abstract]   (10544 Downloads)     |   Abstract (HTML)  (24502 Views)
Type of Study: Original Articles | Subject: Neurosciences
Abstract:   (7890 Views)
Abstract
Background and Objective: Dysfunction and loss of basal forebrain cholinergic neurons and their cortical projections are the earliest pathological events in the pathogenesis of alzheimer disease (AD). This study was done to evaluate the effect of donepezil hydrochloride on reference and working memory caused by mutual electrical lesion of the nucleus basalis magnocellularis (NBM) in animal model of AD.
Methods: In this experimental study, 56 adult male Wistar rats were allocated into 8 group (n=7) including: control (intact), NBM lesion group, which received electrically- induced lesion (0.5 m A, 3s) in NBM, Sham group (the electrode was impaled in to the NBM with no lesion), donepezil groups (lesion + 0.1, 1, 5, 10 mg/kg/bw of donepezil hydrochloride) and vehicle group (NBM lesion+ saline). Acquisition and retention testing were done by using an eight-radial arm maze, in which, the patterns of arm entries in each group was recorded for calculating correct choice, working memory errors, reference memory error and latency.
Results: The spatial learning of animals in the lesion of NBM group significantly reduced in compared to controls (P<0.05). Moreover, no effect on spatial learning was seen in the sham group compared with the lesion group. The post-lesion treatment with donepezil hydrochloride in dose-dependent manner improved the parameters of spatial memory errors in the acquisition and retention tasks in comparision with the lesion group (P<0.05).
Conclusion: Treatment with donepezil hydrochloride, dose-dependently improves cognitive impairment induced by the destruction of the nucleus basalis magnocellularis.
Keywords: Alzheimer disease, Nucleus Basalis Magnocellularis, Memory, Donepezil hydrochloride, Rat
References
1. Khanahmadi M, Farhud D, Malmir M. Genetic of alzheimer's disease: a narrative review article. Iran J Public Health. 2015; 44(7): 892-901.
2. Kroker KS, Rast G, Giovannini R, Marti A, Dorner-Ciossek C, Rosenbrock H. Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP. Neuropharmacology. 2012 Apr;62(5-6):1964-74. doi:10.1016/j.neuropharm.2011.12.021
3. D'Amelio M, Rossini PM. Brain excitability and connectivity of neuronal assemblies in Alzheimer's disease: from animal models to human findings. Prog Neurobiol. 2012 Oct;99(1):42-60. doi:10.1016/j.pneurobio.2012.07.001
4. Dumas JA, Newhouse PA. The cholinergic hypothesis of cognitive aging revisited again: cholinergic functional compensation. Pharmacol Biochem Behav. 2011 Aug; 99(2):254-61. doi:10.1016/j.pbb.2011.02.022
5. Easton A, Sankaranarayanan S, Tanghe A, Terwel D, Lin AX, Hoque N, et al. Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer's disease. Psychopharmacology (Berl). 2013 Nov;230(2):279-89. doi:10.1007/s00213-013-3152-3
6. Raghanti MA, Simic G, Watson S, Stimpson CD, Hof PR, Sherwood CC. Comparative analysis of the nucleus basalis of Meynert among primates. Neuroscience. 2011 Jun; 184:1-15. doi:10.1016/j.neuroscience.2011.04.008
7. Nyakas C, Granic I, Halmy LG, Banerjee P, Luiten PG. The basal forebrain cholinergic system in aging and dementia. Rescuing cholinergic neurons from neurotoxic amyloid-42 with memantine. Behav Brain Res. 2011 Aug; 221(2):594-603. doi:10.1016/j.bbr.2010.05.033
8. Paleja M, Girard TA, Herdman KA, Christensen BK. Two distinct neural networks functionally connected to the human hippocampus during pattern separation tasks. Brain Cogn. 2014 Nov; 92C:101-111. doi:10.1016/j.bandc.2014.10.009
9. Yamaguchi Y, Higashi M, Matsuno T, Kawashima S. Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat. Jpn J Pharmacol. 2001 Nov; 87(3):240-4.
10. Gratwicke J, Kahan J, Zrinzo L, Hariz M, Limousin P, Foltynie T, et al. The nucleus basalis of Meynert: a new target for deep brain stimulation in dementia? Neurosci Biobehav Rev. 2013 Dec; 37(10 Pt 2): 2676-88. doi:10.1016/j.neubiorev.2013.09.003
11. Saxena G, Patro IK, Nath C. ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor. Behav Brain Res. 2011 Oct; 224(1):50-7. doi:10.1016/j.bbr.2011.04.039
12. Shahraki A, Ghahghaei A, Zakeri Z. [Glutamate transporters and excitotoxicity in nervous system]. J Gorgan Univ Med Sci. 2011; 13(3): 1-15. [Article in Persian]
13. Akaike A, Takada-Takatori Y, Kume T, Izumi Y. Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. J Mol Neurosci. 2010 Jan; 40(1-2): 211-6. doi:10.1007/s12031-009-9236-1
14. Creed MC, Milgram NW. Amyloid-modifying therapies for alzheimer's disease: Therapeutic progress and its implication. Age (Dordr). 2010 Sep; 32(3): 365-84. doi:10.1007/s11357-010-9142-z
15. Kapai NA, Bukanova JV, Solntseva EI, Skrebitsky VG. Donepezil in a narrow concentration range arguments control and impaired by beta-amyloid peptide hippocampal LTP in NMDA-independent manner. Cell Mol Neurobiol. 2012; 32: 219-26.
16. Cutuli D, De Bartolo P, Caporali P, Tartaglione AM, Oddi D, D'Amato FR, et al. Neuroprotective effects of donepezil against cholinergic depletion. Alzheimers Res Ther. 2013 Oct; 5(5):50. doi:10.1186/alzrt215
17. Freret T, Bouet V, Quiedeville A, Nee G, Dallemagne P, Rochais C, Boulouard M. Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice. Behav Brain Res. 2012 Apr; 230(1): 304-8. doi:10.1016/j.bbr.2012.02.012
18. Shen H, Kihara T, Hongo H, Wu X, Kem WR, Shimohama S, et al. Neuroprotection by donepezil against glutamate exitotoxicity involves stimulation of alpha7 nicotonic receptors and internalization of NMDA receptor. British J Pharmacol. 2010; 161(1): 127-39. doi:10.1111/j.1476-5381.2010.00894.x
19. Liu P, Bilkey DK. The effects of NMDA lesions centered on the postrhinal cortex on spatial memory tasks in the rat. Behav Neurosci. 2002 Oct; 116(5):860-73.
20. Davis CP, Franklin LM, Johnson GS, Schrott LM. Prenatal oxycodone exposure impairs spatial learning and/or memory in rats. Behav Brain Res. 2010 Sep; 212(1):27-34. doi:10.1016/j.bbr.2010.03.022
21. Lindner MD, Hogan JB, Hodges DB Jr, Orie AF, Chen P, Corsa JA, et al. Donepezil primarily attenuates scopolamine-induced deficits in psychomotor function, with moderate effects on simple conditioning and attention, and small effects on working memory and spatial mapping. Psychopharmacology (Berl). 2006 Nov;188(4):629-40. doi:10.1007/s00213-006-0556-3
22. Zahedi M, Hojjati MR, Fathpour H, Rabiei Z, Alibabaei Z, Basim A. Effect of Rheum Ribes Hydro-Alcoholic Extract on Memory Impairments in Rat Model of Alzheimer's Disease. Iran J Pharm Res. 2015 Fall; 14(4):1197-206.
23. Rabiei Z, Rafieian-Kopaei M, Heidarian E, Saghaei E, Mokhtari S. Effects of Zizyphus jujube extract on memory and learning impairment induced by bilateral electric lesions of the nucleus Basalis of Meynert in rat. Neurochem Res. 2014 Feb; 39(2):353-60. doi:10.1007/s11064-013-1232-8
24. Mesulam MM. Some cholinergic themes related to Alzheimer's disease: synaptology of the nucleus basalis, location of m2 receptors, interactions with amyloid metabolism, and perturbations of cortical plasticity. J Physiol Paris. 1998 Jun-Aug;92(3-4):293-8.
25. Takada-Takatori Y, Kume T, Izumi Y, Ohgi Y, Niidome T, Fujii T, et al. Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation. Biol Pharm Bull. 2009 Mar;32(3):318-24.
26. Xu AJ, Chen Z, Yanai K, Huang YW, Wei EQ. Effect of 3-[1-(phenylmethyl)-4-piperidinyl]-1- (2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)- 1- propanone fumarate, a novel acetylcholinesterase inhibitor, on spatial cognitive impairment induced by chronic cerebral hypoperfusion in rats. Neurosci Lett. 2002 Oct; 331(1):33-6.
27. Spowart-Manning L, van der Staay FJ. The T-maze continuous alternation task for assessing the effects of putative cognition enhancers in the mouse. Behav Brain Res. 2004 May; 151(1-2):37-46.
28. Sharma B, Singh N, Singh M. Modulation of celecoxib- and streptozotocin-induced experimental dementia of Alzheimer's disease by pitavastatin and donepezil. J Psychopharmacol. 2008 Mar; 22(2):162-71. doi:10.1177/0269881107081553
Send email to the article author

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Eskandary A, Moazedi A A, Najaphzadevarzi H, Akhond M R. Effect of donepezil hydrochloride on reference and working memory impairment after bilateral electrical lesion of nucleus basalis magnocellularis in rats model of Alzheimer disease. J Gorgan Univ Med Sci 2018; 20 (1) :36-42
URL: http://goums.ac.ir/journal/article-1-3275-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 20, Issue 1 (3-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 36 queries by YEKTAWEB 4645