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:: Volume 19, Issue 4 (12-2017) ::
J Gorgan Univ Med Sci 2017, 19(4): 73-79 Back to browse issues page
Value of neutrophil to lymphocyte ratio in the prognosis of death of patients with venous thromboembolism
Mojtaba Zare Ebrahimabad1 , Hanieh Teymoori1 , Amir Houshang Poorkhani2 , Naser Behnampour3 , Hamid Reza Joshaghani 4
1- M.Sc in Clinical Biochemistry, Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Golestan University of Medical Sciences, Gorgan, Iran
2- Assistant Professor, Department of Internal Medicine, Golestan University of Medical Sciences, Gorgan, Iran
3- Assistant Professor, Health Management and Development Research Center, Department of Biostatistics, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran
4- Professor, Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran , joshaghani@goums.ac.ir
Abstract:   (11415 Views)
Background and Objective: Venous thromboembolism (VTE) is a common clinical condition with a mortality rate of 15-20%. Neutrophil to lymphocyte ratio (NLR) is known as an indicator in predicting clinical outcomes in patients with various diseases and malignancies. This study was conducted to determine the value of neutrophil to lymphocyte ratio in the prognosis of death in patients with venous thromboembolism during the short term.
Methods: This retrospective cohort study was performed on 93 hospitalized patients with spontaneous venous thromboembolism in Gorgan, northern Iran during 2012-15. Demographic, blood and biochemical parameters of the patients were evaluated in the prediction of fatal outcome in a follow-up of 30 days after thrombose diagnosis.
Results: Sixteen patients (17.2%) died within 30 days. The variables of age, white blood cells, neutrophils, NLR, creatine kinase MB and lactate dehydrogenase significantly increased (P<0.05), and lymphocyte also platelet significantly reduced within the occurrence of death in a short period of 30 days follow up (P<0.05). A cut-off point of 7.21≤NLR had sensitivity, specificity, positive and negative predictive value of 56.3%, 87%, 47.3% and 90.5%, respectively.
Conclusion: Neutrophil to lymphocyte ratio can be used as a useful biomarker in the prediction of mortality during short periods of time in VTE patients.
Keywords: Venous thromboembolism, Neutrophil to lymphocyte ratio, Survival
Full-Text [PDF 302 kb] [English Abstract]   (18488 Downloads) |   |   Abstract (HTML)  (676 Views)  
Type of Study: Original Articles | Subject: Internal Medicine
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Zare Ebrahimabad M, Teymoori H, Poorkhani A H, Behnampour N, Joshaghani H R. Value of neutrophil to lymphocyte ratio in the prognosis of death of patients with venous thromboembolism. J Gorgan Univ Med Sci 2017; 19 (4) :73-79
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Volume 19, Issue 4 (12-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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