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:: Volume 19, Issue 3 (10-2017) ::
J Gorgan Univ Med Sci 2017, 19(3): 24-31 Back to browse issues page
Combination thrapy of hydroalcoholic extract of Pistacia atlantica kurdica and fluvoxamine on spatial memory of immobilization rat
M Mohammadzadeh1 , F Babaeifar 2, F Babaei1
1- Assistant Professor, Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran
2- M.Sc Student in Animal Physiology, Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran , fatemehbabaei706@yahoo.com
Abstract:   (11341 Views)
Background and Objective: Oxidative stress causes disorder in the brain processes including memory. Pistacia atlantica kurdica (pistachio) contains antioxidant compounds, oleic and linoleic acid. Fluvoxamine is an antidepressant medicine which inhibits serotonin reuptake. This study was done to determine the effect of hydroalcoholic extract of pistachio and fluvoxamine on spatial memory of male rats under immobilization stress.
Methods: This experimental study was done on 30 adult male Wistar rats in 5 groups (n=6). The control group was not under immobilization stress. Animals in the stress group were just under immobilization stress. Animals in the pistachio group were under immobilization stress and were received 400 mg/kg/bw hydroalcoholic extract of pistachio. Animals in the fluvoxamine group under immobilization stress were received 120 mg/kg/bw fluvoxamine. Animals under immobilization stress, in the pistachio plus fluvoxamine group were received 400 mg/kg/bw hydroalcoholic extract of pistachio and fluvoxamine 120 mg/kg/bw. The radial arm maze test was used for evaluation of spatial memory. After the animals’ decapitation, the malondialdehyde and catalase level in hippocampus and the serum level of corticosterone and blood glucose were measured.
Results: The stress significantly increased the time of reaching to target, malondialdehyde, corticoestron and blood glucose level, and reduced the catalase in stress group in comprasion with controls (P<0.05). In the pistachio and the pistachio+fluvoxamine treated groups, the time of reaching to target, malondialdehyde, corticoestron and blood glucose level significantly reduced and the catalase level significantly increased in comprasion with stress group (P<0.05) but fluvoxamine significantly increased the time of reaching to target, malondialdehyde and blood glucose, and reduced the corticoestron and catalase in compared to controls (P<0.05).
Conclusion: The immobilization stress led to attenuation of spatial memory and the fluvoxamine administration as an antidepressant drug caused to deterioration of memory,while the treatment with pistachio extract lead to improve the memory.
Keywords: Pistacia atlantica kurdica, Fluvoxamine, Immobilization stress, Spatial memory, Rat
Full-Text [PDF 404 kb] [English Abstract]   (12068 Downloads) |   |   Abstract (HTML)  (925 Views)  
Type of Study: Original Articles | Subject: Physiology - Pharmacology
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Mohammadzadeh M, Babaeifar F, Babaei F. Combination thrapy of hydroalcoholic extract of Pistacia atlantica kurdica and fluvoxamine on spatial memory of immobilization rat . J Gorgan Univ Med Sci 2017; 19 (3) :24-31
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Volume 19, Issue 3 (10-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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