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:: Volume 19, Issue 3 (10-2017) ::
J Gorgan Univ Med Sci 2017, 19(3): 38-46 Back to browse issues page
Evaluation of factors associated with time to sputum smear conversion in smear-positive pulmonary TB patients in Golestan province, Iran (2009-14)
H Sadeghzadeh1 , K Etemad * 2, Y Mehrabi3 , H Hatami4 , T Riyahi5 , HR Kamaliniya6
1- M.Sc Student of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Assistant Professor, Department of Epidemiology, Environmental and Occupational Hazards Control Research Center, Faculty of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran , etemadk@gmail.com
3- Professor, Department of Epidemiology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Professor, Department of Master of Public Health, Faculty of Public Health, Shahid Beheshti University of Medical Sciences , Tehran, Iran
5- Assistant Professor, Department of Internal Medicine, Golestan University of Medical Sciences, Gorgan, Iran
6- General Physician, Deputy for Health, Golestan University of Medical Sciences, Gorgan, Iran
Keywords: Tuberculosis, Sputum smear, Time Sputum conversion
Full-Text [PDF 327 kb] [English Abstract]   (14149 Downloads)     |   Abstract (HTML)  (11498 Views)
Type of Study: Original Articles | Subject: Infectious Medicine
Abstract:   (1079 Views)
Background and Objective: Tuberculosis caused by Mycobacterium tuberculosis is one of the deadliest infectious diseases in the world. The amount of the bacilli in tuberculosis will reduce rapidly by starting effective antibiotic treatment and the remained bacilli in the sputum will be an important scale to respond to treatment. This study was conducted to evaluate the examin factors associated with the conversion of positive smear to negative one in tubercular-pulmonary patients in Golestan province, in northern Iran.
Methods: This retrospective cohort study was carried out on 2093 patients with smear positive pulmonary tuberculosis registered in Golestan province, northern Iran from March 2009-14 referred to health centers. The outcome of this study was to determine the time of changing to negative of the first smear during the treatment and evaluating its relationship with demographic variables, the density of bacilli in the smear, culture, chest x-ray, diabetes and HIV.
Results: 67.5% of patients among 2093 smear-positive pulmonary tuberculosis patients were conversion rate of smear at the end of the second months. Results of Cox model showed relationship between gender, age, weight, density bacillus smear and culture results at the start of treatment and negative smears(P<0.05). Old age, low weight, high density of bacillus in primary smear in the beginning of treatment and increasing of the number of colonies in culture of positive smear patients were considered as predictor factors in changing positive smear to negative one.
Conclusion: This study revealed that Conversion rate and treatment success in Golestan province was less than what was expected.
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Sadeghzadeh H, Etemad K, Mehrabi Y, Hatami H, Riyahi T, Kamaliniya H. Evaluation of factors associated with time to sputum smear conversion in smear-positive pulmonary TB patients in Golestan province, Iran (2009-14). J Gorgan Univ Med Sci 2017; 19 (3) :38-46
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Volume 19, Issue 3 (10-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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