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:: Volume 19, Issue 1 (3-2017) ::
J Gorgan Univ Med Sci 2017, 19(1): 20-24 Back to browse issues page
Short term effect of Fe2NiO4 nanoparticles on kidney function indeces in rat
N Azadeh1 , Z Hoshmandi 2, M Setorki3
1- M.Sc in Animal Physiology, Department of Biology, Hamedan Branch, Islamic Azad University, Hamedan, Iran
2- Assistant Professor, Department of Biology, Sanandaj Branch, Islamic Azad University,Sanandaj, Iran , zhoushmandi@yahoo.com
3- Assistant Professor, Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
Abstract:   (9833 Views)

Background and Objective: Iron oxide nanoparticles, including nanoparticles is important in industry and medicine. Nanoparticles affect on detoxification of environmental pollutants such as Pesticides and chlorinated organic solvents.This study was done to evaluate the short term effect of Fe2NiO4 composite nanoparticle on kidney function indeces in wistar rats.

Methods: In this experimental study, Twenty four Wistar rat were randomly allocated into three groups, including: control, treated groups 1 and 2. Animales in control, treated groups 1 and 2 were received 0.5cc of saline, 0.5cc of solution containing 100, 200 ppm Fe2NiO4 for 7 days, respectively. Uric acid, ceratinine and urea (BUN) were measured at day 2, 7 and 14.

Results: BUN level in treated groups 1 and 2 significantly reduced in comparison with control group at day 7, 14 after intervention (P<0.05). Uric acid level in treated groups 1 and 2 significantly increased at day 7 and 14. 2 week after intervention, the mean creatinine levels in treated group 2 group significantly reduced in compare  to the in treated group 1 and controls (P<0.05).

Conclusion: It seems that the application of Fe2NiO4 nanoparticles in biological system has no toxic effect on the kidney function indeces.

Keywords: Nanoparticle, Fe2NiO4, Kidney, Urea, Uric acid, Creatinine, Rat
Full-Text [PDF 349 kb] [English Abstract]   (14443 Downloads) |   |   Abstract (HTML)  (844 Views)  
Type of Study: Original Articles | Subject: Nanobiotecnology
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Azadeh N, Hoshmandi Z, Setorki M. Short term effect of Fe2NiO4 nanoparticles on kidney function indeces in rat . J Gorgan Univ Med Sci 2017; 19 (1) :20-24
URL: http://goums.ac.ir/journal/article-1-3024-en.html


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Volume 19, Issue 1 (3-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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