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:: Volume 19, Issue 1 (3-2017) ::
J Gorgan Univ Med Sci 2017, 19(1): 25-32 Back to browse issues page
Effect of 8 weeks aerobic exercise and vitamin C on liver transaminases activities in obese 8-11 years girls
F Habibzadeh Bizhani1 , M Habibian * 2, P Farzanegi3
1- M.A in Physical Education and Sports Sciences, Sari Branch, Islamic Azad University, Sari, Iran
2- Assistant Professor, Department of Physical Education and Sports Sciences, Qaemshahar Branch, Islamic Azad University, Qaemshahar, Iran , habibian_m@yahoo.com
3- Associate Professor, Department of Physical Education and Sports Sciences, Sari Branch, Islamic Azad University, Sari, Iran
Keywords: Exercise, Obesity, Transaminase, Vitamin C
Full-Text [PDF 287 kb] [English Abstract]   (12652 Downloads)     |   Abstract (HTML)  (10715 Views)
Type of Study: Original Articles | Subject: Exercise Physiology
Abstract:   (1008 Views)

Background and Objective: Liver diseases accompanied with growing of obesity in children. This study was done to evaluate the effect of aerobic exercise and vitamin C intake on liver transaminases activities in 8-11 years obese girls.

Methods: In this quasi-experimental study, 28 obese girls were randomly divided into four equal groups including control, exercise, supplement (500 mg vitamin C tablet, dailly) and combined (500 mg vitamin C, daily plus exercise) groups. Aerobic exercise was consisted of exercise movements at 50% to 70% maximal heart rate and 3 sessions per week for 8 weeks. Fasting blood samples were collected before and 48 hour after the last intervention. Serum transaminases activities were measured by enzymatic colorimetric method.

Results: 8 weeks of aerobic exercise, vitamin C and the combined intervention were associated with a significant reduction in Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) activities (P<0.05) whereas there was no effect on the Alkaline phosphatase activity. All these interventions were associated with significantly greater reduction in the ALT and AST activities ratio in comparision with control group. Combined intervention induced more reduction on percent of variables changes compared with other interventions (P<0.05).

Conclusion: It seems selected aerobic exercise and vitamin C intake may induce their protective effect in obese girls via improvement in liver function.
References
1. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA. 2006 Apr; 295(13): 1549-55. doi:10.1001/jama.295.13.1549
2. Watts K, Jones TW, Davis EA, Green D. Exercise training in obese children and adolescents: current concepts. Sports Med. 2005; 35(5): 375-92.
3. Burgert TS, Taksali SE, Dziura J, Goodman TR, Yeckel CW, Papademetris X, et al. Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat. J Clin Endocrinol Metab. 2006 Nov; 91(11): 4287-94. doi:10.1210/jc.2006-1010
4. Schwimmer JB, Deutsch R, Kahen T, Lavine JE, Stanley C, Behling C. Prevalence of fatty liver in children and adolescents. Pediatrics. 2006 Oct; 118(4): 1388-93. doi:10.1542/peds.2006-1212
5. Molleston JP, White F, Teckman J, Fitzgerald JF. Obese children with steatohepatitis can develop cirrhosis in childhood. Am J Gastroenterol. 2002 Sep; 97(9): 2460-2. doi:10.1111/j.1572-0241.2002.06003.x
6. Schwimmer JB, Pardee PE, Lavine JE, Blumkin AK, Cook S. Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease. Circulation. 2008 Jul; 118(3):277-83. doi:10.1161/CIRCULATIONAHA.107.739920
7. Barshop NJ, Francis CS, Schwimmer JB, Lavine JE. Nonalcoholic fatty liver disease as a comorbidity of childhood obesity. Ped Health. 2009 Jun; 3(3): 271-81. doi:10.2217/phe.09.21
8. Titcomb CP Jr. Liver function tests: what is the risk? J Insur Med. 2003; 35(1): 26-35.
9. Abd Elbasset WK, Bard NM, Elsayed SH, Mohamed MA. Outcomes of resisted exercise on alkaline phosphatase and bilirubin in hepatic female patients with diabesity. Med J Cairo Univ. 2014; 82(2): 167-74.
10. Sull JW, Yun JE, Lee SY, Ohrr H, Jee SH, Guallar E, et al. Body mass index and serum aminotransferase levels in Korean men and women. J Clin Gastroenterol. 2009 Oct; 43(9): 869-75. doi:10.1097/MCG.0b013e3181945956
11. Di Bonito P, Sanguigno E, Di Fraia T, Forziato C, Boccia G, Saitta F, et al. Association of elevated serum alanine aminotransferase with metabolic factors in obese children: sex-related analysis. Metabolism. 2009 Mar; 58(3): 368-72. doi:10.1016/j.metabol.2008.10.010
12. Pacifico L, Cantisani V, Anania C, Bonaiuto E, Martino F, Pascone R, et al. Serum uric acid and its association with metabolic syndrome and carotid atherosclerosis in obesechildren. Eur J Endocrinol. 2009 Jan; 160(1): 45-52. doi:10.1530/EJE-08-0618
13. Larson-Meyer DE, Newcomer BR, Heilbronn LK, Volaufova J, Smith SR, Alfonso AJ, et al. Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function. Obesity (Silver Spring). 2008 Jun; 16(6): 1355-62. doi:10.1038/oby.2008.201
14. Mencin AA, Lavine JE. Advances in pediatric nonalcoholic fatty liver disease. Pediatr Clin North Am. 2011 Dec; 58(6): 1375-92. doi:10.1016/j.pcl.2011.09.005
15. St George A, Bauman A, Johnston A, Farrell G, Chey T, George J. Independent effects of physical activity in patients with nonalcoholic fatty liver disease. Hepatology. 2009 Jul; 50(1): 68-76. doi:10.1002/hep.22940
16. Kistler KD, Brunt EM, Clark JM, Diehl AM, Sallis JF, Schwimmer JB, et al. Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fattyliver disease. Am J Gastroenterol. 2011 Mar; 106(3): 460-8. doi:10.1038/ajg.2010.488
17. Ipsen DH, Tveden-Nyborg P, Lykkesfeldt J. Does vitamin C deficiency promote fatty liver disease development? Nutrients. 2014 Dec; 6(12): 5473-99. doi:10.3390/nu6125473
18. Ortega RM, Rodríguez-Rodríguez E, Aparicio A, Jiménez-Ortega AI, Palmeros C, Perea JM, et al. Young children with excess of weight show an impaired selenium status. Int J Vitam Nutr Res. 2012 Apr; 82(2): 121-9. doi:10.1024/0300-9831/a000101
19. Puchau B, Ochoa MC, Zulet MA, Marti A, Martínez JA, Members G. Dietary total antioxidant capacity and obesity in children and adolescents. Int J Food Sci Nutr. 2010 Nov; 61(7): 713-21. doi:10.3109/09637481003757860
20. Musso G, Gambino R, De Michieli F, Cassader M, Rizzetto M, Durazzo M, et al. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholicsteatohepatitis. Hepatology. 2003 Apr; 37(4): 909-16. doi:10.1053/jhep.2003.50132
21. Bashandy SA, AlWasel SH. Carbon tetrachloride-induced hepatotoxicity and nephrotoxicity in rats: protective role of vitamin C. Journal of Pharmacology and Toxicology. 2011; 6(3): 283-92. doi:10.3923/jpt.2011.283.292
22. Kataoka T, Nishiyama Y, Yamato K, Teraoka J, Morii Y, Sakoda A, et al. Comparative study on the inhibitory effects of antioxidant vitamins and radon on carbon tetrachloride-induced hepatopathy. J Radiat Res. 2012 Nov; 53(6): 830-9. doi:10.1093/jrr/rrs057
23. Adikwu E, Deo O. Hepatoprotective Effect of Vitamin C (Ascorbic Acid). Pharmacol Pharm 2013; 4(1): 84-92. doi:10.4236/pp.2013.41012
24. Zelber-Sagi S, Nitzan-Kaluski D, Goldsmith R, Webb M, Zvibel I, Goldiner I, et al. Role of leisure-time physical activity in nonalcoholic fatty liver disease: a population-based study. Hepatology. 2008 Dec; 48(6): 1791-8. doi:10.1002/hep.22525
25. Perseghin G, Lattuada G, De Cobelli F, Ragogna F, Ntali G, Esposito A, et al. Habitual physical activity is associated with intrahepatic fat content in humans. Diabetes Care. 2007 Mar; 30(3): 683-8.
26. Sreenivasa Baba C, Alexander G, Kalyani B, Pandey R, Rastogi S, Pandey A, et al. Effect of exercise and dietary modification on serum aminotransferase levels in patients with nonalcoholic steatohepatitis. J Gastroenterol Hepatol. 2006 Jan; 21(1 Pt 1): 191-8. doi:10.1111/j.1440-1746.2005.04233.x
27. Johnson NA, Sachinwalla T, Walton DW, Smith K, Armstrong A, Thompson MW, et al. Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology. 2009 Oct; 50(4): 1105-12. doi:10.1002/hep.23129
28. Shamsoddini A, Sobhani V, Ghamar Chehreh ME, Alavian SM, Zaree A. Effect of aerobic and resistance exercise training on liver enzymes and hepatic fat in Iranian men with nonalcoholic fatty liver disease. Hepat Mon. 2015 Oct; 15(10): e31434. doi:10.5812/hepatmon.31434
29. van der Heijden GJ, Wang ZJ, Chu ZD, Sauer PJ, Haymond MW, Rodriguez LM, et al. A 12-week aerobic exercise program reduces hepatic fat accumulation and insulin resistance in obese, Hispanic adolescents. Obesity (Silver Spring). 2010 Feb; 18(2): 384-90. doi:10.1038/oby.2009.274
30. Farris JW, Taylor L, Williamson M, Robinson C. A 12-week interdisciplinary intervention program for children who are obese. Cardiopulm Phys Ther J. 2011 Dec; 22(4): 12-20.
31. Matsuzaka A, Takahashi Y, Yamazoe M, Kumakura N, Ikeda A, Wilk B, et al. Validity of the multistage 20-M shuttle-run test for Japanese children, adolescents, and adults. Pediatric Exercise Science. 2004; 16(2): 113–25. doi:10.1123/pes.16.2.113
32. Slaughter MH, Lohman TG, Boileau RA, Horswill CA, Stillman RJ, Van Loan MD, et al. Skinfold equations for estimation of body fatness in children and youth. Hum Biol. 1988 Oct; 60(5): 709-23.
33. Duncan GE, Howley ET. Metabolic and perceptual responses to short-term cycle training in children. Pediatric Exercise Science. 1998; 10(2): 110-22. http://dx.doi.org/10.1123/pes.10.2.110
34. Fernandes PR, Lira FA, Borba VV, Costa MJ, Trombeta IC, Santos Mdo S, et al. Vitamin C restores blood pressure and vasodilator response during mental stress in obese children. Arq Bras Cardiol. 2011 Jun; 96(6): 490-7. [Article in English, Portuguese, Spanish]
35. Murer SB, Aeberli I, Braegger CP, Gittermann M, Hersberger M, Leonard SW, et al. Antioxidant supplements reduced oxidative stress and stabilized liver function tests but did not reduceinflammation in a randomized controlled trial in obese children and adolescents. J Nutr. 2014 Feb; 144(2): 193-201. doi:10.3945/jn.113.185561
36. Keating SE, Machan EA, O'Connor HT, Gerofi JA, Sainsbury A, Caterson ID, et al. Continuous exercise but not high intensity interval training improves fat distribution in overweight adults. J Obes. 2014; 2014: 834865. doi:10.1155/2014/834865
37. Ip TY, Peterson J, Byrner R, Tou JC. Bone responses to body weight and moderate treadmill exercising in growing male obese (fa/fa) and leanZucker rats. J Musculoskelet Neuronal Interact. 2009 Jul-Sep; 9(3): 155-66.
38. Turan S, Topcu B, Gökçe İ, Güran T, Atay Z, Omar A, et al. Serum alkaline phosphatase levels in healthy children and evaluation of alkaline phosphatase z-scores in different types of rickets. J Clin Res Pediatr Endocrinol. 2011; 3(1): 7-11. doi:10.4274/jcrpe.v3i1.02
39. van Straalen JP, Sanders E, Prummel MF, Sanders GT. Bone-alkaline phosphatase as indicator of bone formation. Clin Chim Acta. 1991 Sep; 201(1-2): 27-33.
40. Amin KA, Nagy MA. Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats. Diabetol Metab Syndr. 2009 Oct; 1(1): 17. doi:10.1186/1758-5996-1-17
41. Eze ED, Dawud FA, Zainab AA, Jimoh A, Malgwi IS, Isa AS. Preliminary studies of effects of vitamin C and Zinc on some liver enzymes in alloxan-induced diabetic wistar rats. Asian Journal of Medical Sciences. 2012; 4(1): 17-22.
42. Molnár D, Decsi T, Koletzko B. Reduced antioxidant status in obese children with multimetabolic syndrome. Int J Obes Relat Metab Disord. 2004 Oct; 28(10): 1197-202. doi:10.1038/sj.ijo.0802719
43. Beydoun MA, Canas JA, Beydoun HA, Chen X, Shroff MR, Zonderman AB. Serum antioxidant concentrations and metabolic syndrome are associated among U.S. adolescents in recent national surveys. J Nutr. 2012 Sep; 142(9): 1693-704. doi:10.3945/jn.112.160416
44. Block G, Jensen CD, Dalvi TB, Norkus EP, Hudes M, Crawford PB, et al. Vitamin C treatment reduces elevated C-reactive protein. Free Radic Biol Med. 2009 Jan; 46(1): 70-7. doi:10.1016/j.freeradbiomed.2008.09.030
45. Bondia-Pons I, Ryan L, Martinez JA. Oxidative stress and inflammation interactions in human obesity. J Physiol Biochem. 2012 Dec; 68(4): 701-11. doi:10.1007/s13105-012-0154-2
46. Paes ST, Marins JC, Andreazzi AE. [Metabolic effects of exercise on childhood obesity: a current view]. Rev Paul Pediatr. 2015 Jan-Mar; 33(1): 122-9. doi:10.1016/j.rpped.2014.11.002 [Article in Portuguese]
47. Valdecantos MP1, Pérez-Matute P, Quintero P, Martínez JA. Vitamin C, resveratrol and lipoic acid actions on isolated rat liver mitochondria: all antioxidants but different. Redox Rep. 2010; 15(5): 207-16. doi:10.1179/135100010X12826446921464
48. Rodríguez-Hernández H1, Cervantes-Huerta M, Rodríguez-Moran M, Guerrero-Romero F. Decrease of aminotransferase levels in obese women is related to body weight reduction, irrespective of type of diet. Ann Hepatol. 2011 Oct-Dec; 10(4): 486-92.
49. Yoo J, Lee S, Kim K, Yoo S, Sung E, Yim J. Relationship between insulin resistance and serum alanine aminotransferase as a surrogate of NAFLD (nonalcoholic fatty liver disease) in obese Korean children. Diabetes Res Clin Pract. 2008 Sep; 81(3): 321-6. doi:10.1016/j.diabres.2008.05.006
50. Elnakish MT, Hassanain HH, Janssen PM, Angelos MG, Khan M. Emerging role of oxidative stress in metabolic syndrome and cardiovascular diseases: important role of Rac/NADPH oxidase. J Pathol. 2013 Nov; 231(3): 290-300. doi:10.1002/path.4255
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Habibzadeh Bizhani F, Habibian M, Farzanegi P. Effect of 8 weeks aerobic exercise and vitamin C on liver transaminases activities in obese 8-11 years girls . J Gorgan Univ Med Sci 2017; 19 (1) :25-32
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Volume 19, Issue 1 (3-2017) Back to browse issues page
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