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:: Volume 18, Issue 2 (6-2016) ::
J Gorgan Univ Med Sci 2016, 18(2): 1-11 Back to browse issues page
Dual molecular mechanism of catalase in cancer and resistance to chemotherapy
Gholamian A1 , Divsalar A * 2
1- M.Sc in Biochemistry‚ Department of Cell and Molecular Biology‚ Faculty of Biological Sciences‚ Kharazmi University, Tehran, Iran
2- Assistant Professor, Department of Cell and Molecular Biology‚ Faculty of Biological Sciences‚ Kharazmi University, Tehran, Iran , divsalar@khu.ac.ir
Abstract:   (13207 Views)

Catalase is the one of the most important antioxidant enzymes that is found abundantly in liver and kidney. The alteration in activity and function this latter enzyme are widely investigated in various types of cancer to understand the cancer mechanism and its treatment. The changes in the catalase activity levels in a variety of cancer cells is as a specific property of tumor tissues due to the reducting catalase activity at mRNA level. In this review, various reports that examined the alterations in catalase activity and resistance to chemotherapy and its complications in the literature are summarized and discussed. Due to the important role of hydrogen peroxide in various stages of cancer process, catalase alters this process by detoxification of hydrogen peroxide. Chemotherapy increase free radicals to destroy the tumor cells, then, catalase activity reduced their impact on cancer cells. On the other hand, it might be concluded that production of drug resistance in chemotherapy is resulted due to increasing catalase activity. Therefor it seems catalase has contradictory influence on the treatment and development of cancer.
Keywords: Catalase, Cancer, Hydrogen peroxide, Chemotherapy
Full-Text [PDF 302 kb] [English Abstract]   (20654 Downloads) |   |   Abstract (HTML)  (904 Views)  
Type of Study: Review Article | Subject: Biochemistry
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Gholamian A, Divsalar A. Dual molecular mechanism of catalase in cancer and resistance to chemotherapy. J Gorgan Univ Med Sci 2016; 18 (2) :1-11
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Volume 18, Issue 2 (6-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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