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Palmatine hydrochloride improves motor dysfunction in streptozotocin-induced diabetic rats
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Ahouei M   1, Vaezi Gh2 , Kalalian Moghaddam H3 |
1- Physiologist , ahouee@yahoo.com
2- Associated Professor, Department of Biology, Faculty of Basic Science, Damghan Branch, Islamic Azad University, Damghan, Iran
3- Assistant Professor, Department of Physiology, Faculty of Medicine, Shahrood University of Medical Sciences, Shahroud, Iran |
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Abstract: (19086 Views) |
| Background and Objective: Diabetes induces motor dysfunctions, Palmatine is an isoquinoline alkaloid, with anti-diabetic and antioxidant activities. This study was conducted to evaluate the effect of Palmatine on motor dysfunction in STZ-induced diabetic rats. Materials and Methods: In this experimental study, 32 male wistar rats were randomly allocated into control, Palmatine-treated non-diabetic, diabetic and Palmatine-treated diabetic groups. Diabetes was induced by STZ administration at the dose of 55 mg/kg/bw, intraperitoneally. Palmatine hydrochloride was administered subcutaneous at doses of 10 mg/kg/bw per day for a period of 6 weeks, one week after induction of diabetes. Blood glucose level was measured 1, 3, 5, 7 weeks after STZ injection. Locomotor activity tests including Y maze, grip-traction and inclined plane tests were performed to determining locomotor activity. Results: In Y maze test, the number of arms entered significantly increased in Palmatine-treated diabetic group compared to diabetic group (P<0.05). Grip traction and inclined plane tests significantly increased in Palmatine-treated diabetic group compared to diabetics animals (P<0.05). Conclusion: Palmatine hydrochloride administration for 6 weeks improves motor dysfunctions in streptozotocin-induced diabetic rats. |
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| Keywords: Diabetes mellitus, Palmatine hydrochloride, Motor dysfunctions, Streptozotocin, Rat |
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Full-Text [PDF 356 kb]
[English Abstract]
(12877 Downloads)
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Type of Study: Original Articles |
Subject:
Physiology - Pharmacology
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