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Effects of vitamin E supplementation on activity of serum Paraoxonase, SOD, GPX enzymes and lipid profiles in beta major thalassemia patients
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Aboomardani M (PhD)1   , Rashidi MR (PhD)2 , Rafraf M (PhD) * 3, Arefhosseini SR (PhD)4 , Keshtkar AA (PhD)5 , Joshaghani HR (PhD)6 |
1- Assistant Professor, Department of Biochemistry, Faculty of Medicine, Golestan University of Medical Sciences, Grogan, Iran
2- Professor, Drug Applied Research Center, Department of Medicinal Chemistry, Tabriz University of Medical Sciences, Tabriz, Iran
3- Associate Professor, Nutritional Research Center, Department of Community Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran , rafrafm@tbzmed.ac.ir
4- Assistant Professor, Department of Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
5- Assistant Professor, Department of Development of Health Sciences, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
6- Associate Professor, Department of Medical Laboratory, Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran |
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Abstract: (21631 Views) |
| Background and Objective: In pathogenesis of beta major thalassemia, tissue damage is occurring due to oxidative stress. The present study was designed to evaluate the effects of vitamin E supplementation on serum Paraoxonase, SOD, GPX enzyme activity and lipid profiles in beta major thalassemia patients. Materials and Methods: In this clinical tiral study, Sixty (25 males, 35 females) beta major thalassemia patients with age≥18 years who had criterias to enter the study, were selected randomely in two groups. The patients in interventional group, vitamin E at a dose of 400 mg/day were given for three months, with no supplementations in control group. The enzyme activities of paraoxonase, SOD, GPX and lipid profiles (LDL-c, HDL-c, triglyceride, total Antixidant Capacity) were measured prior and after 3 months in both case and control groups. Data analyzed by using paired t-test. Results: Significant increases in serum levels of vitamin E, Paraoxonase activity, HDL cholesterol (P<0.001), BMI (P≤0.001) and a significant reduction in GPX activity (P<0.05) were observed in cases compared to controls. Conclusion: The vitamin E supplementation may be useful in reducing oxidative stress and lipid profiles in beta major thalassemic patients. |
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| Keywords: Vitamin E, Beta major thalassemia, Paraoxonase-1, SOD, GPX, Lipid profiles |
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Full-Text [PDF 293 kb]
[English Abstract]
(14559 Downloads)
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Type of Study: Original Articles |
Subject:
Biochemistry - Nutrition
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