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:: Volume 21, Issue 1 (3-2019) ::
J Gorgan Univ Med Sci 2019, 21(1): 46-51 Back to browse issues page
Protective effect of melatonin and Amphotericin B in affected rats with Aspergillosis
Hossein Nowrozi * 1, Ali Kazemi2 , Mahsa Shokri3
1- Assistant Professor, Department of Laboratory Sciences, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran , nowrozi.h@iums.ac.ir
2- Assistant Professor, Department of Pharmacology, Science and Research Branch, Islamic Azad University, Tehran, Iran
3- Academic Instructor, Department of Microbiology, College of Medical Sciences, Varamin- Pishva Branch, Islamic Azad University, Varamin, Iran
Abstract:   (9068 Views)
Background and Objective: Fungal diseases are increasing in immunocompromised patients. One of the important fungal disseases is Aspergillosis. Few studies have been conducted on the effects of melatonin on fungal diseases. This study was performed to determine the protective effect of melatonin and Amphotericin B in Aspergillosis in rat model.
Methods: This experimental study was done on 40 Wistar rat with weight ranging from 200 to 250 grams. Animals were allocted in five groups. The first group was positive control (immunocompromised condition with cyclophosphamide and inoclusion of Aspergillus spore). The second groupe was negative control (without drug and inoclusion of Aspergillus spore) and the third group was treated by melatonin (200 μg/kg). The forth group was treated by Amphotericin B and fifth group was treated by melatonin plus Amphotericin B, IL.6 and TNFα were measured in the first and tenth days after contamination.
Results: The level of the IL.6 and TNFα in three interventional treated groups significantly reduced in compared to positive control group in first and tenth days (P<0.05). The level of the IL.6 and TNFα in melatonin plus Amphotericin B group significantly reduced in comparison with Amphotericin B and melatonin treated groups in first and tenth days (P<0.05).
Conclusion: Melatonin with Amphotericin B increases immune competent system in rats affected with Aspergillosis.
 
Keywords: Melatonin, Amphotericin B, Aspergillosis, IL.6, TNFα
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Type of Study: Original Articles | Subject: Mycology
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Nowrozi H, Kazemi A, Shokri M. Protective effect of melatonin and Amphotericin B in affected rats with Aspergillosis. J Gorgan Univ Med Sci 2019; 21 (1) :46-51
URL: http://goums.ac.ir/journal/article-1-3286-en.html
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Volume 21, Issue 1 (3-2019) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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