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:: Volume 18, Issue 4 (12-2016) ::
J Gorgan Univ Med Sci 2016, 18(4): 100-104 Back to browse issues page
Prevalence of Extended-Spectrum Beta Lactamase enzymes in clinical isolates of Enterobacteriaceae family
SM Moosavian1 , A Rezvanirad * 2
1- Associate Professor, Department of Microbiology, Faculty of Medicine, Ahwaz Jondishapur University of Medical Sciences, Ahwaz, Iran
2- M.Sc Student of Microbiology, Department of Microbiology, Ahwaz Jondishapur University of Medical Sciences, Ahwaz, Iran , a1027rezvani@yahoo.com
Abstract:   (9482 Views)

Background and Objective: Extended-Spectrum Beta Lactamase enzymes (ESBLs) are the most important factor for antimicrobial resistance in Enterobacteriaceae The resistance to beta-lactam antibiotics is the main problem in the bacterial infections therapy. This study was done to determine the prevalence of Extended-Spectrum Beta Lactamase enzymes in clinical isolates of Enterobacteriaceae family.

Methods: In this descriptive study, 240 isolates of Enterobacteriaceae family were collected from clinical specimens obtained in Shohada, Rahimi and Madani hospitals in Khorramabad city, Iran. Antibiotic susceptibility of isolates was performed by disk diffusion method. ESBLs production in all isolates was determined using the combination disk method.

Results: Bacteria strains isolated in this study were Escherichia coli (76%), Klebsiella pneumonia (16.2%), Citrobacter (5.4%), Enterobacter spp. (0.83%) and Proteus (1.6%). The results of antimicrobial susceptibility of isolates showed that the highest rate of antibiotic resistance was toward Ampicillin (88%) and Cefotaxime (43%) and the lowest rate was observed to Amikacin (2.5%). According to the results of the phenotypic tests, 141(59%) isolates out of 240 Enterobacteriaceae were beta-lactamase producers.

Conclusion: ESBL producer isolates and antibiotic resistant due to of Enterobacteriaceae isolated from clinical samples from hospitals are high prevalence in Khorramabad city, Iran.
Keywords: Enterobacteriaceae, Extended-Spectrum Beta Lactamase, Escherichia coli, Klebsiella pneumonia
Full-Text [PDF 184 kb] [English Abstract]   (16539 Downloads) |   |   Abstract (HTML)  (1288 Views)  
Type of Study: Short Communication | Subject: Microbiology
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Moosavian S, Rezvanirad A. Prevalence of Extended-Spectrum Beta Lactamase enzymes in clinical isolates of Enterobacteriaceae family. J Gorgan Univ Med Sci 2016; 18 (4) :100-104
URL: http://goums.ac.ir/journal/article-1-2963-en.html
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Volume 18, Issue 4 (12-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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