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Effect of aerobic exercise and alpha lipoic acid supplement on insulin resistance in females with type 2 diabetes
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Daryanoosh F *   1, Shkibaie M2 , Zamanie A3 , Mohammadi M4 |
1- Associate Professor, Department of Exercise Physiology, Faculty of Education and Psychology, Shiraz University, Shiraz, Iran , daryanoosh@shirazu.ac.ir
2- M.Sc in Exercise Physiology, Department of Exercise Physiology, Faculty of Education and Psychology, Shiraz University, Shiraz, Iran
3- Assistant Professor, Department of Internal Medicine, Shiraz University of Medical Sceinces, Shiraz, Iran
4- Assistant Professor, Department of Educational Administration, Faculty of Education and Psychology, Shiraz University, Shiraz, Iran |
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Abstract: (8435 Views) |
| Background and Objective: Alpha lipoic acid (ALA) is a powerful biological antioxidant which is involved in metabolism and energy production as a co-factor in mitochondrial dehydrogenase enzyme complex. This study was done to evaluate the effect of aerobic exercise and alpha lipoic acid supplement on insulin resistance in females with type 2 diabetes. Methods: In this quasi-experimental study, 44 females with type 2 diabetes divided into four groups including: control, supplementation, training and supplementation + training groups. Patients of supplementation and complex (supplementation + training) groups took three 100mg ALA capsules per day for eight weeks. The training program consisted of 8 weeks and three sessions per week. In each session, the subjects warmed up for 10-15 minutes, ran on a treadmill with the intensity of 40-50% of maximum heart rate for 30 minutes and then cooled down for 5-10 minutes. Blood samples were taken after 12-14 hours fasting in two stages - the beginning and the end of the eighth week. Results: Eight weeks of taking ALA supplements significantly reduced patients' insulin resistance (P<0.05). Eight weeks of running on a treadmill with an intensity of 40-50% of maximum heart rate non-significantly reduced insulin resistance in the training group compared to the controls. In the supplementation + training group a significant reduction of insulin resistance was observed (P<0.05). Conclusion: Alpha lipoic acid supplementation reduces insulin and insulin resistance. While, reduction in fasting blood glucose level causes reduction in insulin resistance in the combination of supplementation and training. |
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| Keywords: Type 2 diabetic, Alpha lipoic acid, Exercise, Insulin |
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Full-Text [PDF 219 kb]
[English Abstract]
(17821 Downloads)
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Type of Study: Original Articles |
Subject:
Exercise Physiology
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