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Diazinon alters sex hormones, Interferon-gamma, Interleukin-4 and 10 in male Wistar rats
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Maliji Gh1   , Jorsaraei SGh * 2, Zabihi E3 , Fattahi E4 , Rezaie E5 , Sohan Faraji A6 |
1- Assistant Professor, Department of Microbiology and Immunology, Babol University of Medical Sciences, Babol, Iran
2- Associate Professor, Fatemh Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran , alijorsara@yahoo.com
3- Assistant Professor, Cellular and Molecular Research Center, Babol University of Medical Sciences, Babol, Iran
4- Assistant Professor, Department of Biology, Islamic Azad University, Ayatollah Amoli Branch, Amol, Iran
5- Medical Student, Babol University of Medical Sciences, Babol, Iran
6- MSc of Embryology, Department of Anatomical Sciences, Babol University of Medical Sciences, Babol, Iran |
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Abstract: (12921 Views) |
| Background and Objective: Agricultural toxins including organochlorine and organophosphorus families cause damages in the various tissues in humans. Diazinon is a non-systemic organophosphate insecticide. This study was carried out to determine the effect of Diazinon on sex hormone, interferon gamma, interleukin-4 and 10 in male rats. Methods: In this experimental study 24 adult male Wistar rats were randomly allocated into four groups. Three experimental groups were received Diazinon 5 days per week for one month at 0.3, 3 and 30 mg/kg/bw intraperitoneally, while controls received nothing. Seven days after the last injection, blood samples were obtained and the serum testosterone, FSH, LH, interferon gamma, interleukin-4 and interleukin-10 were measured. Results: Serum level of Interleukin-10 significantly increased in experimental group (30 mg/kg/bw of Diazinon) compared to controls (P<0.05). Serum level of Interleukin-10 significantly decreased in 0.3 mg/kg/bw and 3mg/kg/bw of Diazinon groups compared to controls (P<0.05). Interleukin-4 level was only significant in the group receiving 30 mg/kg/bw of Diazinon (P<0.05). Reduction in interferon-gamma level was not significant between control and experimental groups. FSH significantly reduced in the three experimental groups in comparison with controls (P<0.05). Testosterone level was significantly increased in experimental groups compared to control (P<0.05). Conclusion: Diazinon increases interleukin-10 and testosterone and reduces FSH hormone in the rat. |
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| Keywords: Diazinon, Interleukin-10, FSH, LH, Testosterone, Rat |
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Full-Text [PDF 277 kb]
[English Abstract]
(16917 Downloads)
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Type of Study: Original Articles |
Subject:
Anatomy
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Maliji Gh, Jorsaraei SGh, Zabihi E, Fattahi E, Rezaie E, Sohan Faraji A. Diazinon alters sex hormones, Interferon-gamma, Interleukin-4 and 10 in male Wistar rats . J Gorgan Univ Med Sci 2014; 16 (1) :22-28 URL: http://goums.ac.ir/journal/article-1-1969-en.html
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