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:: Volume 7, Issue 1 (Spring & Summer 2005) ::
J Gorgan Univ Med Sci 2005, 7(1): 26-30 Back to browse issues page
Evaluation of neurotoxic effects of lead acetat on rat radial nerve
M.Mehdizadeh (PhD) *1 , F.Kermanian (MSc) , G.Farjah (PhD) , PN.Tabatabaei (BSc)
Abstract:   (25490 Views)
Background&Objective: Lead toxicity is a common popular problem. Many researches were performed about this toxicity both in-vivo and in-vitro since 100 years ago.Those studies showed that lead have toxic effects such as behavioral disorders, decrease of IQ and decrease of learning and memory. Also lead has neurotoxic effects such as decrease of neuronal density in visual cortex of monkey, cell death in hippocampus and decrease of acetylcolin in rat’s hippocampus. In this study we examin neurotoxic effects of lead on rat’s radial nerve because radial nerve is a mix nerve. Materials&Methods: 24 adult male rats were divided in six groups. Groups I and II received lead acetate 4% and 2%, groups III and IV received disttiled water and normal water for one month.After this time, we killed rats and exposed radial nerve from behind of arm.Then studied them with light and electron microscopy. Results: In experimental groups we saw decrease of myelin sheath diameter and decrease of nuclear density in schwann cell. Also we saw many granules in mitochondrial matrix, active macrophage, edema and disarrangement of myelin sheath layers. Conclusion: We suggest that lead neurophaty is due to schwann cell injury and this lesion lead to decrease of myelin sheath.
Keywords: Myelin, Radial nerve, Lead (Pb), Rat, Neurotoxicity
Full-Text [PDF 616 kb] [English Abstract]   (22499 Downloads)    
Type of Study: Original Articles | Subject: General
* Corresponding Author Address: Department of Anatomy Iran University of Medical Sciences. maranaoo@iums.ac.ir


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M.Mehdizadeh (PhD), F.Kermanian (MSc), G.Farjah (PhD), PN.Tabatabaei (BSc). Evaluation of neurotoxic effects of lead acetat on rat radial nerve. J Gorgan Univ Med Sci 2005; 7 (1) :26-30
URL: http://goums.ac.ir/journal/article-1-7-en.html


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Volume 7, Issue 1 (Spring & Summer 2005) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)