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Tissue trans-glutaminase antibody in Inflammatory Bowel Disease in Golestan province, Northern Iran (2005-08)
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Amiriani T1   , Besharat S * 2, Semnani Sh3 , Joshaghani HR4 , Roshandel GhR5 , Keshtkar AA6 , Kiaii MR7 , Mirkarimi HS8 , Hashemi-Nasab SZ8 , Zendeh-Bad AS5 |
1- Assistant Professor, Department of Internal Medicine, Golestan Research Center of Gastroentrology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
2- General Physician, Researcher, Golestan Research Center of Gastroentrology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran , besharat@goums.ac.ir
3- Associate Professor, Department of Internal Medicine, Golestan Research Center of Gastroentrology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
4- Associate Professor, Department of Biochemistry, Biochemistry and Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
5- General Physician, Researcher, Golestan Research Center of Gastroentrology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
6- Assistant Professor, Department of Development of Health Sciences, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
7- Faculty of Paramedicine, Golestan Research Center of Gastroentrology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
8- Researcher, Golestan Research Center of Gastroentrology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran |
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Abstract: (21668 Views) |
Background and Objective: Celiac is a hereditary disease presented with chronic inflammation of small intestine. Several studies supposed a relationship between Celiac disease and Inflammatory Bowel Disease (IBD). Tissue trans-glutaminase antibody is one of the best serological markers in Celiac disease. This study was designed to evaluate the association of Celiac and IBD using tissue trans-glutaminase antibody.
Materials and Methods: In this descriptive study 127 confirmed IBD patients who were referred by gastroentrologists 2005-08 enrolled into the study. A questionnaire was completed and tissue trans-glutaminase antibody was evaluated with ELISA method with a Cut-off=12 U/ml.
Results: Among 127 referred patients, serum samples of 102 patients were collected. Mean±SD of age was 36.17±15.2 years and 48% were males. Ulcerative colitis, Crohn’s disease and other colitis were observed in 76 (74.5%), 7 (6.9%) and 19 (18.6%) of patients, respectively. Tissue trans-glutaminase antibody was positive (19.8 U/L) in one 46-years-old male patient with ulcerative colitis.
Conclusion: Tissue trans-glutaminase antibody titer was not significantly different between IBD patients and controls, thus it seems not appropriate to suggest as one of the routine tests in IBD patients.
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| Keywords: Inflammatory Bowel Disease, Celiac, Tissue trans-glutaminase antibody |
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Full-Text [PDF 205 kb]
[English Abstract]
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Type of Study: Short Communication |
Subject:
Internal Medicine
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Amiriani T, Besharat S, Semnani Sh, Joshaghani HR, Roshandel GhR, Keshtkar AA, et al . Tissue trans-glutaminase antibody in Inflammatory Bowel Disease in Golestan province, Northern Iran (2005-08). J Gorgan Univ Med Sci 2011; 13 (1) :127-131 URL: http://goums.ac.ir/journal/article-1-978-en.html
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