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The effect of fruit Cassia fistula aqueous extract on sleeping time and the level of anxiety in mice
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Vafaei AA (PhD)1   , Miladi-Gorgi H (MSc) * 2, Moghimi HR(MD)3 , Ameri M (MD)3 |
1- Associate Professor, Department of Physiology, Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran
2- Acacemic Insrtucter, Department of Physiology, Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran , miladi331@yahoo.com
3- General Physician |
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Abstract: (33099 Views) |
| Background and Objective: Several investigations have indicated the antinociceptive, anti-inflammatory, antipyretic effects and smooth muscle relaxant activity of Cassia species. This study was done to determine the effect of Cassia fistula on sleeping time and the level of anxiety in mice. Materials and Methods: In this experimental study, 80 male albino mice (25-30 g) randomly allocated in 8 groups. For measuring the sleeping time we used the Angle method and animals were divided into three experimentals (250, 500 and 1000 mg/kg) and one control group. For evaluating of anxiety levels, animals randomly were divided into three experimentals and one control group, and elevated plus maze (EPM) model was used. The evaluation of anxiety indices included number and percent of time spent in open arm. Different doses of the aqueous extract of Cassia fistula (250, 500, 1000 mg/kg IP) were injected intraperitoneally to the treated groups. Controls were recived 10 ml/kg/BW normal saline intraperitoneally in both methods. Results: The extract of Cassia fistula (250, 500 and 1000 mg/kg) significantly increased sleeping time [F (3, 39)=23.19, P<0.05]. Also open time [F (3,39)=15.55, P<0.05] and the number of open arm entries [F (3, 39)=24.21, P<0.05] were significantly in doses (250mg and 500 mg) were singnificantly more than control group, respectively (P<0.05). Conclusion: This study showed that the aqueous extract of Cassia fistula fruit incerase the sleeping time and deereasing level of anxity in mice. |
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| Keywords: Cassia fistula, Sleeping time, Anxiety, Elevated plus maze |
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Full-Text [PDF 286 kb]
[English Abstract]
(20460 Downloads)
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Type of Study: Original Articles |
Subject:
Physiology - Pharmacology
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