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The study of total Phytolacca Decandra's effect on the electrophysiological properties of atrioventricular node of isolated rat heart
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Khori V (PhD) *   1, Nayebpour SM (PhD) , Ashrafian Y (Pharm.D) , Hajiakhondi A (PhD) |
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Abstract: (25605 Views) |
| This study was designed to evaluate the effects of total extract of Phytolacca Decandra on electrophysiological properties of atrioventricular node. Male rat heart after isolation was attached to a Langendorff perfusion system. The stimulation protocol was carried out during control condition (No intervention) and on the presence of selected concentration (1.10-7 %w/v, 2.10-7 %w/v, 5.10-7 %w/v) of Phytolacca Decandra. The basic (Wenchebach, AVCT and ERP) and functional (Recovery) properties of AV-node were studied in solated, perfused male rat cardiac preparations. Total extract of P.decandra significantly increased WBCL, AVCT and ERP in the concentration dependent manner, but had no significant effect on the time constant of recovery. The results of this study demonstrate that total extract of P.decandra had parasympathic-like effect on time-independent properties of AV-node and the above results also showed a potential anti-arrhythmic role of P.decandra in terminating supraventricular tachyarrhythmia. |
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| Keywords: Arrhythmia, Langendorff system, Atrioventricular node, Electrophysiology, Phytolacca decandra |
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Full-Text [PDF 1449 kb]
(14408 Downloads)
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Type of Study: Original Articles |
Subject:
General
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| * Corresponding Author Address: Department of Pharmacology, Gorgan University of Medical Sciences |
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