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:: Volume 20, Issue 3 (10-2018) ::
J Gorgan Univ Med Sci 2018, 20(3): 31-39 Back to browse issues page
Comparison the effect of eight weeks aerobic training with moderate and high intensities on serum levels of Irisin and Uncoupling Protein 1 (UCP-1) in white adipose tissue in obese male rats
Keyvan Hejazi1 , Seyyed Reza Attarzadeh Hosseini * 2, Mehrdad Fathi3 , Mohammad Mosaferi Ziaaldini4 , Mahdieh Zaeemi5
1- Ph.D Candidate in Sport Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
2- Professor in Sport Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran. attarzadeh@um.ac.ir , attarzadeh@um.ac.ir
3- Associate Professor in Sport Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
4- Assistant Professor in Sport Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
5- Assistant Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
Abstract:   (8472 Views)
Background and Objective: The synthesis of uncoupling protein 1 (UCP1) in adipose tissue plays an important role in providing resistance and prevention of fat accumulation, weight gain and obesity. This study was done to evaluate the effect of eight weeks aerobic training with moderate and high intensities on serum levels of Irisin and UCP1 white adipose tissue in obese male rats.
Methods: In this experimental study, 24 adult obese male Wistar rats (weight: 250 to 300 gr, BMI>30g/cm2) were randomly assigned into three groups including moderate aerobic training intensity, high intensity aerobic training and control group. The aerobic exercise training was included 8 weeks (5 sessions/per-week for 60 min per session). All training groups carried out aerobic training with 28 m/min (moderate intensity), aerobic training with 34 m/min (high intensity) on treadmill. 48 hours after the training period, the level of UCP1 and Irisin protein was measured.
Results: The level of UCP-1 in adipose tissue and serum Irisin in both aerobic training intensities increased compared to control group, but this increase only in aerobic training group with a moderate intensity was singnificant (p<0.05).
Conclusion: Eight weeks aerobic training with moderate intensity leads to increase of UCP-1 in adipose tissue and Irisin levels.
Keywords: Aerobic training, Irisin, Uncoupling protein 1, White adipose tissue
Full-Text [PDF 330 kb] [English Abstract]   (14531 Downloads) |   |   Abstract (HTML)  (347 Views)  
Type of Study: Original Articles | Subject: Exercise Physiology
* Corresponding Author Address: Professor in Sport Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran. attarzadeh@um.ac.ir
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Hejazi K, Attarzadeh Hosseini S R, Fathi M, Mosaferi Ziaaldini M, Zaeemi M. Comparison the effect of eight weeks aerobic training with moderate and high intensities on serum levels of Irisin and Uncoupling Protein 1 (UCP-1) in white adipose tissue in obese male rats. J Gorgan Univ Med Sci 2018; 20 (3) :31-39
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