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:: Volume 20, Issue 2 (7-2018) ::
J Gorgan Univ Med Sci 2018, 20(2): 42-47 Back to browse issues page
Analgesic and anti-inflammatory effects of ethanolic extract of Hyssopus officinalis in mice
Azadeh Salehi1 , Mahbubeh Setorki * 2
1- M.Sc in Animal Physiology, Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
2- Associate Professor, Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran. doctor.setorgi@gmail.com , doctor.setorgi@gmail.com
Abstract:   (9882 Views)
Background and Objective: Finding the pain relieving substances is one of the important aims of biological researches. This study was done to evaluate the antinociceptive, anti-inflammatory effects of Hyssopus officinalis extract in mice.
Methods: In this experimental study, 100 male adult mice were allocated into 5 experimental groups including control group receiving only normal saline and groups that received extract of Hyssopus officinalis at doses of 25, 50 and 75 mg/kg/bw, and positive control group in formalin test received morphine in acute and chronic phase of experiment and positive control group in anti-inflammatory test received dexamethasone. Formalin-induced paw licking was used to determine the anti-nociceptive activity of Hyssopus officinalis extract. The anti-inflammatory activity was determined by Xylene test.
Results: In the acute phase of pain (the first 5 minutes), doses of 50 and 75 mg/kg/bw (7.75±2.3, 8.75±2.1) of the Hyssopus officinalis extract significantly reduced the number of feet raised (P<0.05). Also, in the chronic phase of pain (20 min second), 25, 50 and 75 mg/kg/bw of doses (17.25±2.3, 11.75±2.9, 2.7±10.75) and morphine significantly reduced the duration of foot lift (P<0.05). The extract of Hyssopus officinalis with three doses of 25, 50 and 75 mg/kg/bw (13.33±3.1, 20±3.1, 19.83±2.8) showed high anti-inflammatory activity against Xylene induced ear edema (P<0.05).
Conclusion: This study showed that Hyssopus officinalis extract can inhibit pain and inflammation in animal model.
Keywords: Hyssopus officinalis, Formalin test, Xylene test, Pain, Inflammation, Mice
Full-Text [PDF 353 kb] [English Abstract]   (14545 Downloads) |   |   Abstract (HTML)  (423 Views)  
Type of Study: Original Articles | Subject: Pharmacology
* Corresponding Author Address: Associate Professor, Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran. doctor.setorgi@gmail.com
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Salehi A, Setorki M. Analgesic and anti-inflammatory effects of ethanolic extract of Hyssopus officinalis in mice. J Gorgan Univ Med Sci 2018; 20 (2) :42-47
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Volume 20, Issue 2 (7-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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