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:: Volume 20, Issue 1 (3-2018) ::
J Gorgan Univ Med Sci 2018, 20(1): 96-101 Back to browse issues page
Insulin resistance in hypothyroid patients using HOMA and triglyceride- glucose indices
Ebrahim Mehdavi1 , Sharebeh Hezarkhani2 , S.Mehran Hosseini * 3
1- General Physician, Golestan University of Medical Sciences, Gorgan, Iran
2- Endocrinologist, Gorgan, Iran
3- Associate Professor, Department of Physiology, Neuroscience Research Center, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. hosseini@goums.ac.ir , hosseini@goums.ac.ir
Abstract:   (17712 Views)
Background and Objective: Insulin resistance (IR) is common in hypothyroidism. IR is one of risk factors for cardiovascular disease. Insulin clamp is the gold standard method for evaluation of IR but it is not routine in clinical usage. The triglyceride- glucose (TyG) and homeostasis model assessment (HOMA) indices are non-invasive surrogate of IR. This study was done to determine the IR using the TyG and HOMA indices in hypothyroid patients.
Methods: This descriptive-analytic study was done on 23 hypothyroid patients including 15 overt and 8 subclinical hypothyroid patients. All patients were new cases and were matched for age, sex, and high. TSH, FT4, TG, LDL, FBS and fasting plasma insulin level were measured twice at time of diagnosis and after treatment and the changes of TyG and HOMA indices were recorded.
Results: In two groups IR based on HOMA was more than TyG index. IR in overt hypothyroidism based on HOMA index was more than two times in comparison with TyG index at the first time and more than three times (10:3) at the second time. IR in subclinical hypothyroidism based on HOMA index was more than four times in comparison with TyG index at the first time and more than three times (7:2) at the second time. A significant difference was found in IR based on HOMA before and after treatment (P<0.05). There were not any significant differences in IR indices of overt hypothyroidism group.
Conclusion: The eight weeks treatment of hypothyroidism and reducing TSH level is probably having no effect on HOMA and TyG in overt and subclinical hypothyroidism.
Keywords: Insulin resistance, TyG index, Glucose, Hypothyroidism
Full-Text [PDF 255 kb] [English Abstract]   (13576 Downloads) |   |   Abstract (HTML)  (846 Views)  
Type of Study: Original Articles | Subject: Internal Medicine
* Corresponding Author Address: Associate Professor, Department of Physiology, Neuroscience Research Center, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. hosseini@goums.ac.ir
References
1. Eckel RH, The metabolic syndrome. In: Harrison’s principles of internal medicine 19th ed . Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editros. New York: McGrawhill. 2015; pp: 2449-54.
2. Dimitriadis G, Mitrou P, Lambadiari V, Boutati E, Maratou E, Panagiotakos DB, et al. Insulin action in adipose tissue and muscle in hypothyroidism. J Clin Endocrinol Metab. 2006 Dec; 91(12): 4930-7. doi:10.1210/jc.2006-0478
3. Gierach M, Gierach J, Junik R. Insulin resistance and thyroid disorders. Endokrynol Pol. 2014;65(1):70-6. doi:10.5603/EP.2014.0010
4. Maratou E, Hadjidakis DJ, Kollias A, Tsegka K, Peppa M, Alevizaki M, et al. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur J Endocrinol. 2009 May; 160(5):785-90. doi:10.1530/EJE-08-0797
5. Dullaart RP, van den Berg EH, van der Klauw MM, Blokzijl H. Low normal thyroid function attenuates serum alanine aminotransferase elevations in the context of metabolic syndrome and insulin resistance in white people. Clin Biochem. 2014 Aug;47(12):1028-32. doi:10.1016/j.clinbiochem.2014.04.016
6. Irace C, Carallo C, Scavelli FB, De Franceschi MS, Esposito T, Tripolino C, et al. Markers of insulin resistance and carotid atherosclerosis. A comparison of the homeostasis model assessment and triglyceride glucose index. Int J Clin Pract. 2013 Jul; 67(7):665-72. doi:10.1111/ijcp.12124
7. Gayoso-Diz P, Otero-Gonzalez A, Rodriguez-Alvarez MX, Gude F, Cadarso-Suarez C, García F, et al. Insulin resistance index (HOMA-IR) levels in a general adult population: curves percentile by gender and age. The EPIRCE study. Diabetes Res Clin Pract. 2011 Oct;94(1):146-55. doi:10.1016/j.diabres.2011.07.015
8. Borai A, Livingstone C, Kaddam I, Ferns G. Selection of the appropriate method for the assessment of insulin resistance. BMC Med Res Methodol. 2011 Nov; 11:158. doi:10.1186/1471-2288-11-158
9. Ivović M, Marina LV, Vujović S, Tančić-Gajić M, Stojanović M, Radonjić NV, et al. Nondiabetic patients with either subclinical Cushing's or nonfunctional adrenal incidentalomas have lower insulin sensitivity than healthy controls: clinical implications. Metabolism. 2013 Jun;62(6):786-92. doi:10.1016/j.metabol.2012.12.006
10. Lee SH, Kwon HS, Park YM, Ha HS, Jeong SH, Yang HK, et al. Predicting the development of diabetes using the product of triglycerides and glucose: the Chungju Metabolic Disease Cohort (CMC) study. PLoS One. 2014 Feb; 9(2):e90430. doi:10.1371/journal.pone.0090430
11. Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord. 2008 Dec;6(4):299-304. doi:10.1089/met.2008.0034
12. Jameson JL, Weetman AP. Disorders of thyroid gland. In: Longo D, Fauci A, Kasper D, Hauser S, Jameson JL, Loscalzo J. Harrison's Principles of Internal Medicine. 18th ed. New York: McGraw-Hill Professional. 2012; p: 2921.
13. Esteghamati A, Ashraf H, Esteghamati AR, Meysamie A, Khalilzadeh O, Nakhjavani M, et al. Optimal threshold of homeostasis model assessment for insulin resistance in an Iranian population: the implication of metabolic syndrome to detect insulin resistance. Diabetes Res Clin Pract. 2009 Jun; 84(3):279-87. doi:10.1016/j.diabres.2009.03.005
14. Lee SH, Han K, Yang HK, Kim HS, Cho JH, Kwon HS, et al. A novel criterion for identifying metabolically obese but normal weight individuals using the product of triglycerides and glucose. Nutr Diabetes. 2015 Apr; 5(4): e149. doi:10.1038/nutd.2014.46
15. Guerrero-Romero F, Simental-Mendía LE, González-Ortiz M, Martínez-Abundis E, Ramos-Zavala MG, Hernández-González SO, et al. The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp. J Clin Endocrinol Metab. 2010 Jul;95(7):3347-51. doi:10.1210/jc.2010-0288
16. Vasques AC, Novaes FS, de Oliveira Mda S, Souza JR, Yamanaka A, Pareja JC, et al. TyG index performs better than HOMA in a Brazilian population: a hyperglycemic clamp validated study. Diabetes Res Clin Pract. 2011 Sep;93(3):e98-e100. doi:10.1016/j.diabres.2011.05.030
17. Stanická S, Vondra K, Pelikánová T, Vlcek P, Hill M, Zamrazil V. Insulin sensitivity and counter-regulatory hormones in hypothyroidism and during thyroid hormone replacement therapy. Clin Chem Lab Med. 2005;43(7):715-20. doi:10.1515/CCLM.2005.121
18. Al Sayed A, Al Ali N, Bo Abbas Y, Alfadhli E. Subclinical hypothyroidism is associated with early insulin resistance in Kuwaiti women. Endocr J. 2006 Oct;53(5):653-7.
19. Sridevi A, Vivekanand B, Giridhar G, Mythili A, Subrahmanyan KAV. Insulin resistance and lipid alterations in subclinical hypothyroidism. Indian J Endocrinol Metab. 2012 Dec; 16(Suppl 2): S345-S346. doi:10.4103/2230-8210.104085
20. Mohamed Nada A. Effect of treatment of overt hypothyroidism on insulin resistance. World J Diabetes. 2013 Aug; 4(4): 157-61. doi:10.4239/wjd.v4.i4.157
21. Keskek SO, Kirim S, Tasdemir M, Tuzun D, Ortoglu G, Saler T. Insulin resistance in patients with hypothyroidism or hyperthyroidism without hepatosteatosis. Endocrine Abstracts. 2013; 32: P1020. doi:10.1530/endoabs.32.P1020
22. Chen Y, Wu X, Wu R, Sun X, Yang B, Wang Y, Xu Y. Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism. Sci Rep. 2016 May 19;6:26174. doi:10.1038/srep26174
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Mehdavi E, Hezarkhani S, Hosseini S. Insulin resistance in hypothyroid patients using HOMA and triglyceride- glucose indices . J Gorgan Univ Med Sci 2018; 20 (1) :96-101
URL: http://goums.ac.ir/journal/article-1-3284-en.html
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Volume 20, Issue 1 (3-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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