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:: Volume 19, Issue 4 (12-2017) ::
J Gorgan Univ Med Sci 2017, 19(4): 8-14 Back to browse issues page
Effect of vitamin E on serum level of sexual hormones and number of ovarian follicles exposed to sodium meta- bisulphite
Zohreh Manshad1 , Seyyed Ebrahim Hosseini * 2
1- M.Sc in Animal Physiology, Department of Biology, Faculty of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2- Associate Professor, Department of Biology, Faculty of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran , ebrahim.hossini@yahoo.com
Abstract:   (12308 Views)
Background and Objective: Sodium meta-bisulphite is used as a preservative in food and pharmaceutical industries. The aim of this study was to determine the effect of vitamin E on the improvement of sodium-meta bisulphite-induced complications on ovarian tissue and sex hormones in rats.
Methods: In this experimental study, 70 adult Wistar rats were randomly allocated into 7 groups including control, sham and interventional groups were received vitamin E (200 mg/kg/bw), sodium metabisulfite (520 mg/kg/bw), and sodium meta-bisulphite (520 mg/kg/bw) was combined with vitamin E in 50, 100 and 200 mg/kg/bw doses. Prescriptions were taken as gavage for 30 days. Blood samples were taken from animals to measure LH, FSH, estrogen and progesterone hormones. Ovaries were removed and follicles were counted after tissue sections.
Results: The concentration of estrogen hormones, progesterone, LH, FSH and number of ovarian follicles in the groups receiving sodium meta-bisulphite and vitamin E alone was significantly lower than control group (P<0.05). In animals treated with sodium meta-bisulphite and vitamin E at 100 and 200 mg/kg/bw, no significant difference was observed. However, in animals which were simultaneously treated with meta-bi-sulfite sodium and vitamin E at dose 100 and 200 mg/kg, in compared with the control group, significant improvement was not observed.
Conclusion: Sodium meta-bisulphite consumption with 50, 100 and 200 mg/kg body weight of vitamin E can reduce the effect of sodium meta-bisulphite on ovarian follicles and sex hormones.
Keywords: Sodium Metabisulfite, Vitamin E, Ovarian follicle, Estrogen, Progesterone, LH, FSH, Rat
Full-Text [PDF 237 kb] [English Abstract]   (14963 Downloads) |   |   Abstract (HTML)  (854 Views)  
Type of Study: Original Articles | Subject: Physiology - Pharmacology
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Manshad Z, Hosseini S E. Effect of vitamin E on serum level of sexual hormones and number of ovarian follicles exposed to sodium meta- bisulphite . J Gorgan Univ Med Sci 2017; 19 (4) :8-14
URL: http://goums.ac.ir/journal/article-1-3221-en.html
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Volume 19, Issue 4 (12-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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