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:: Volume 8, Issue 4 (12-2006) ::
J Gorgan Univ Med Sci 2006, 8(4): 23-27 Back to browse issues page
Decrease of erythrocyte cholinesterase in pesticide factory workers
Joshaghani HR * 1, Ahmadi AR , Behnampour N
Abstract:   (19715 Views)
Background&Objective: Two enzymes have the ability to hydrolyze acetylcholine. One is acetylcholinesterase, which is called true cholinesterase, it is found in erythrocytes. The other cholinesterase is pseudocholinesterase, it is found in serum. Some chemical components of organophosphates group and carbamates affected cholinesterase activity. Determination of cholinesterase has application in diagnosis of liver disease, liver damage by insecticide and assessment of fatty liver. Pesticide factory workers are one group of peoples which are exposed of poisoning by pesticide. Materials&Methods: This research in 2005 performed in pesticide producers. In two stages (3 month interval) from 58 of personal blood was drown. Results: Mean of erythrocyte cholinesterase in first stage was 48.5±11.2 IU/gHb and second stage was 37.9±17.3 IU/gHb. Decrease of erythrocyte cholinesterase was significant differences (paired t test, P<0.05). Increase of serum AST was not statistically significant. Increase of serum ALT and Albumin was significant differences (paired t test, p<0.05). In 15 individual (25.9 %) cholinesterase decrease more than 35% and in 16 workers (27.6 %) erythrocyte cholinesterase decrease between 26-35%. Conclusion: Since in more than 26% of personnel cholinesterase decreased over than 35%, routine assessment of cholinesterase in similar factory, is recommended.
Keywords: Cholinesterase, Erythrocyte, Organophosphate, Pesticide
Full-Text [PDF 230 kb] [English Abstract]   (17763 Downloads)    
Type of Study: Original Articles | Subject: General
* Corresponding Author Address: joshaghanihr@goums.ac.ir


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Joshaghani HR, Ahmadi AR, Behnampour N. Decrease of erythrocyte cholinesterase in pesticide factory workers . J Gorgan Univ Med Sci 2006; 8 (4) :23-27
URL: http://goums.ac.ir/journal/article-1-84-en.html


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Volume 8, Issue 4 (12-2006) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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