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Seroepidemiology of celiac disease among blood donor in Golestan province
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Joshaghani HR *   1, Semnani Sh , Mirrezaee A , Abdolahi N , Besharat S , Behnampour N , Dehbashi Gh , Roshandel Gh |
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Abstract: (24726 Views) |
| Background&Objective: Celiac is a digestive disease. In this disease, small bowel is damaged and the absorption of nutrients are adversely affected. These patients do not absorb gluten. There is probably a correlation between esophagus cancer and celiac. The aim of this research was to study the seroepidemiology celiac disease in this area with high prevalency of esophagus cancer. Materials&Methods: This research was a descriptive study, which was performed on blood donors in Golestan province during the year 2005-06. blood samples were taken from 2547 subjects. tTG-IgA determination were carried out using ElISA technique, the titre<4U/ml, 4-10U/ml and >10Um/l were considered to be as negative, weakly positive and positive respectively. EMA antibody assessment were carried out on all sample population with more than 4U/ml, using IFA method. Results: 28 subjects (1.1%) had tTG-Ab positive test, out of this number 18 subjects (0.7%) were weakly positive and 10 persons (0.4%) were considered to be positive. EMA test were positive in 70% of subjects with tTG positive results. There was not any significant meaning between positive tTG test and ethnicity from weakly positive tTG, 15 subjects (83.3%) and 3 subjects (16.7%) were male and female respectively. The entire tTG positive were male subjects. Conclusion: In regard to high prevalency of esophagus cancer in the region and the relation of celiac disease with above cancer, it seems necessary to look more seriously at the celiac disease. |
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| Keywords: Antiendomysial antibodies, Tissue transglutaminase, Celiac, Golestan, Esophagus cancer |
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Full-Text [PDF 198 kb]
[English Abstract]
(16490 Downloads)
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Type of Study: Original Articles |
Subject:
General
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| * Corresponding Author Address: joshaghanihr@goums.ac.ir |
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