|
|
|
|
 |
Volume 8, Issue 2 (7-2006) |
 |
|
|
|
|
The effect of essence of Citrus aurantium on the electrophysiological properties of isolated perfused rabbit AV-node
|
V.Khori (PhD) *1   , M.Naebpour (PhD) , E.Rakhshan , A.MirAbbasi , M.Zamani (MSc) |
|
|
|
Abstract: (27791 Views) |
| Background & Objective: Pharmacological studies and traditional medical literature point to the cardiovascular effects of the Citrus aurantium L. (Rutaceae) in many instances. In the present study, we used isolated perfused AV-node of rabbit as an experimental model to determine the effect of various concentrations of essence of Citrus aurantium (0.1-0.3 v/v) on electrophysiological properties of isolated heart. The second goal of the present study was to assess the protective role of essence of Citrus aurantium on arrhythmogenic effects of ouabain. Materials & Methods: This was a semi-experimental study. We used isolated perfused rabbit AV-nodal preparation, in three groups. In the first group, the effect of various concentration of the Citrus aurantium (0.1, 0.2, 0.3 ml/l) was assesed on the AV-node. In the second and third groups, the effect of Citrus aurantium was tested in the presence of ouabain (0.1?molar) and verapamil (0.1?molar). We used 6 rabbit in each group. Statistical analysis was preformed by SPSS Mean±SE was used in the all results. Results: Our results showed depressant effects of extract of Citrus aurantium on Wenchebach Cycle Length (WBCL), AV Conduction Time (AVCT), Effective and Functional Refractory Periods (ERP & FRP). Rate-dependent properties such as Facilitation and fatigue significantly increased by Citrus.a (0.3ml/l). We had significant increase in the AVCT (32.6±3.6 to 40±6.08 msec) and FRP (147±5.1 to 166.6±3.6 msec) by Citrus.a. We had a protective role of Citrus aurantium on ouabain induced AV-nodal depression. The magnitude of facilitation and fatigue in the concentration of 0.3 C.aurantium was 7.5±0.3 and 6.5±0.5, respectively. Conclusion: The above results indicated potential inhibitory and antiarrhythmic effect of Citrus aurantium in treating supraventricular tachyarrhythmia. |
|
| Keywords: Citrus aurantium, Isolated AV-node, Arrhythmia, Herbal drugs |
|
|
Full-Text [PDF 390 kb]
[English Abstract]
(24106 Downloads)
|
|
Type of Study: Original Articles |
Subject:
General
|
| * Corresponding Author Address: Department of Pharmacology Gorgan University of Medical Sciences. vaph99@yahoo.com |
|
|
|
|
|
|
V.Khori (PhD), M.Naebpour (PhD), E.Rakhshan, A.MirAbbasi, M.Zamani (MSc). The effect of essence of Citrus aurantium on the electrophysiological properties of isolated perfused rabbit AV-node. J Gorgan Univ Med Sci 2006; 8 (2) :1-7 URL: http://goums.ac.ir/journal/article-1-56-en.html
|
|
|
|
|
|
|
