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:: Volume 11, Issue 2 (7-2009) ::
J Gorgan Univ Med Sci 2009, 11(2): 23-27 Back to browse issues page
The combination effect of dexamethasone with either metoclopramide or propofol on nusea and vomiting afther general anesthesia
Yousef Mortazavi (MSc) * 1, Ebrahim Alijanpour(PhD) , Omeleila Rabei(MSc) , Hossein Babatabar (MSc) , Ebrahim Nasiri (MSc)
Abstract:   (21563 Views)

Background and Objective: A common complication after general anesthesia is nausea and vomiting followed by different problems such as spasm, hypoxia and pulmonary aspiration. This complication is more common in patients with full stomach, Eye injury, head trauma, cesarean and laparoscopy. Propofol and metoclopramide are two common drugs to prevent nausea and vomiting after operation. On the other hand adding dexamethasone to the above drug, has an important effect on decreasing nausea and vomiting. In this study, the effect propofol and metoclopramide associated with dexamethasone on nausea and vomiting after operation was investigated.

Materials and Methods: In this clinical trial study, 100 patients with ASA I, II classes, aged 16-60 years with selective orthopedic surgery randomly have divided into two groups. In group one, 48 patients received metoclopramide (10mg) with dexamethasone (8mg) and in group two, 52 patients received propofol (20mg) with dexamethasone (8mg), five minutes before the end of operation. Prevalence of nausea and vomiting in both groups was considered after 4 hours and results were analyzed by Chi-Square, t-student and Fisher exact tests.

Results: The rate of nausea in group 1 and 2 was 35.4% and 11.5% respectivly (P<0.05). The rate of vomiting was 27.7% and 7.7% in group 1 and 2 respectivly (P<0.05).

Conclusion: This study showed that the antiemetic effect of propofol with dexamethasone is more effective to prevent nausea and vomiting than metoclopromide with dexamethasone.

Keywords: Nausea, Vomiting, Propofol, Metoclopramid, Dexamethasone, General anesthesia
Full-Text [PDF 192 kb] [English Abstract]   (14549 Downloads)    
Type of Study: Original Articles | Subject: General
* Corresponding Author Address: Academic Instrcture, Department of Anesthesiology, Faculty of Paramedicine, Babol University of Medical Sciences, Babol, Iran. mortazavi1337@yahoo.com


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Yousef Mortazavi (MSc), Ebrahim Alijanpour(PhD), Omeleila Rabei(MSc), Hossein Babatabar (MSc), Ebrahim Nasiri (MSc). The combination effect of dexamethasone with either metoclopramide or propofol on nusea and vomiting afther general anesthesia. J Gorgan Univ Med Sci 2009; 11 (2) :23-27
URL: http://goums.ac.ir/journal/article-1-531-en.html


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Volume 11, Issue 2 (7-2009) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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