[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Indexing Sources::
Editorial Board::
Executive Members::
Articles Archive::
Instruction to Authors::
Contact Us::
Site Facilities::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 11, Issue 1 (3-2009) ::
J Gorgan Univ Med Sci 2009, 11(1): 43-48 Back to browse issues page
Seromarkers of Hepatitis B virus in newborns with HBsAg positive mothers
Yousef Yahyapour (PhD) * 1, Mohammad Karimi (MD) , Nooshin Khayyer (MD) , Ali Hashemzade-Omran (MSc) , Seyyed Mohammad Jazayeri (PhD) , Zahra Saadatmand (BSc) , Mahmoud Mahmoudi (PhD)
Abstract:   (28456 Views)
Background and Objective: One of the most important routes of hepatitis B virus (HBV) transmission is from asymptomatic carrier mothers to their infants. It has been concluded that over 50% of Iranian carriers have contracted the infection perinatally, making this the most likely route of transmission of HBV in our country. In this study, we assessed the rate of HBV infection in children were born to HBsAg positive mothers that received hepatitis B immunoglobulin (HBIG) and the first dose of vaccine at birth and the second and third of doses of vaccine at 1 and 6 months of age, respectively. Materials and Methods: In this descreptive study, 123 infants born from HBsAg positive mothers assessed and serum sample of these subjects were tested by ELISA technique for detection of HBsAg, Anti-HBs and Anti-HBc markers. Data were then analyzed by the chi-square and fisher exact tests. Results: From 31241 pregnant women with delivery during this 5-years study about 140 (0.45%) of them were HBsAg positive. Children born to these mothers follow-up and 123 serum samples of them tested for serologic markers of HBV infection. HBsAg was found in 0.8% of the children and 91.9% had one or more serologic markers of HBV infection. Protective rate (Anti-HBs positive) and Anti-HBc positive were 82.1% and 8.9% respectively. Conclusion: This study showed that after having focuced on the vertical transmission route for many years, and implementing strategies such as vaccination and HBIG injection to neonates of HBsAg positive mothers, nowadays it seems that we should pay attention to horizontal route of HBV transmission in this area.
Keywords: HbsAg, Anti-HBs, Anti-HBc, HBsAg positive mothers, Newborn
Full-Text [PDF 216 kb] [English Abstract]   (13820 Downloads) |   |   Abstract (HTML)  (666 Views)  
Type of Study: Original Articles | Subject: General
* Corresponding Author Address: uyahyapoor@yahoo.com

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Yousef Yahyapour (PhD), Mohammad Karimi (MD), Nooshin Khayyer (MD), Ali Hashemzade-Omran (MSc), Seyyed Mohammad Jazayeri (PhD), Zahra Saadatmand (BSc) et al . Seromarkers of Hepatitis B virus in newborns with HBsAg positive mothers. J Gorgan Univ Med Sci 2009; 11 (1) :43-48
URL: http://goums.ac.ir/journal/article-1-461-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 11, Issue 1 (3-2009) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 36 queries by YEKTAWEB 4657