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Relationship of Antral Follicle Count and Anti-Mullerian Hormone with Ovarian Response in Infertile Women
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Shamim Mosallami1    , Moghadaseh Jahanshahi *2 , Fatemeh Sadat Hosseini3 , Somayeh Livani4 , Sima Besharat5 |
1- Medical Student, Research Student Committee, Golestan University of Medical Sciences, Gorgan, Iran.
2- Assistant Professor of Infertility, Clinical Research Development Unit (CRDU), Sayyad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran. , mogh.jahanshahi@gmail.com
3- Assistant Professor of Reproductive Biology, Clinical Research Development Unit (CRDU), Sayyad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran.
4- Associate Professor of Radiology, Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran.
5- Associate Professor of Biomedical Sciences (By Research), Golestan Research Center of Gastroenterology and Hepatology, Jorjani Clinical Sciences Research Institute, Golestan University of Medical Sciences, Gorgan, Iran. |
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Abstract: (386 Views) |
Background and Objective: Pregnancy success in infertile women depends on various factors, including oocyte quality, immunological factors, and endometrial receptivity. To evaluate ovarian reserve, parameters such as age, follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), and antral follicle count (AFC) are considered. This study was conducted to determine the relationship of AFC and AMH with ovarian response in infertile women referring to an infertility center.
Methods: This descriptive-analytical study was conducted on 50 women (mean age = 33.88±5.32 years) who were candidates for assisted reproductive technology (ART) at the Nahal Infertility Center, Shahid Sayad Shirazi Hospital, in 2020. Serum levels of AMH, FSH, luteinizing hormone (LH), complete blood count (CBC), liver function tests (LFTs), thyroid function tests (TFTs), blood urea nitrogen (BUN), creatinine (Cr), and prolactin (PRL) were measured using enzyme-linked immunosorbent assay (ELISA), while FSH levels were measured via radioimmunoassay (RIA). Transvaginal ultrasound was performed on the third day of the menstrual cycle to determine the AFC.
Results: The mean duration of infertility was 4.8±2.8 years. Thirty-three women (66%) had primary infertility, and in 35 cases (70%), the cause of infertility was related to female factors. The mean and standard deviation serum levels of AMH and AFC were 4.8±4 ng/ml and 9±5 ng/ml, respectively. Poor ovarian response to treatment was observed in 8% of cases. Ovarian response showed a statistically significant correlation with AFC (P<0.05). Furthermore, AFC and AMH indices had significant statistical correlations with the ovarian response (P<0.05).
Conclusion: The AFC and AMH indices can be considered reliable predictors of ovarian response in infertile women.
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Keywords: Infertility, Female [MeSH], Anti-Mullerian Hormone [MeSH], Ovarian Follicle [MeSH]
Article ID: Vol27-36 |
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Full-Text [PDF 643 kb]
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Type of Study: Original Articles |
Subject:
Reproduction & Infertility
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Mosallami S, Jahanshahi M, Hosseini F S, Livani S, Besharat S. Relationship of Antral Follicle Count and Anti-Mullerian Hormone with Ovarian Response in Infertile Women. J Gorgan Univ Med Sci 2025; 27 (4) :54-62 URL: http://goums.ac.ir/journal/article-1-4557-en.html
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