1. Vranić L, Mikolašević I, Milić S. Vitamin D Deficiency: Consequence or Cause of Obesity? Medicina (Kaunas). 2019 Aug;55(9):541. doi: 10.3390/medicina55090541. [DOI] [PubMed]

2. Dobnig H, Pilz S, Scharnagl H, Renner W, Seelhorst U, Wellnitz B, et al. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med. 2008 Jun;168(12):1340-49. doi: 10.1001/archinte.168.12.1340. [DOI] [PubMed]

3. Semba RD, Houston DK, Bandinelli S, Sun K, Cherubini A, Cappola AR, et al. Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality in older community-dwelling adults. Eur J Clin Nutr. 2010 Feb;64(2):203-209. doi: 10.1038/ejcn.2009.140. [DOI] [PubMed]

4. Galesanu C, Mocanu V. Vitamin D deficiency and the clinical consequences. Rev Med Chir Soc Med Nat Iasi. 2015 Apr-Jun;119(2):310-18. [PubMed]

5. Vatandost S, Jahani M, Afshari A, Amiri MR, Heidarimoghadam R, Mohammadi Y. Prevalence of vitamin D deficiency in Iran: A systematic review and meta-analysis. Nutr Health. 2018 Dec;24(4):269-78. doi: 10.1177/0260106018802968. [DOI] [PubMed]

6. Tabrizi R, Moosazadeh M, Akbari M, Dabbaghmanesh MH, Mohamadkhani M, Asemi Z, et al. High Prevalence of Vitamin D Deficiency among Iranian Population: A Systematic Review and Meta-Analysis. Iran J Med Sci. 2018 Mar;43(2):125-39. [PubMed]

7. Daniel D, Hardigan P, Bray N, Penzell D, Savu C. The incidence of vitamin D deficiency in the obese: a retrospective chart review. J Community Hosp Intern Med Perspect. 2015 Feb;5(1):26069. doi: 10.3402/jchimp.v5.26069. [DOI] [PubMed]

8. Bennour I, Haroun N, Sicard F, Mounien L, Landrier JF. Vitamin D and Obesity/Adiposity-A Brief Overview of Recent Studies. Nutrients. 2022 May;14(10):2049. doi: 10.3390/nu14102049. [DOI] [PubMed]

9. Hengist A, Perkin O, Gonzalez JT, Betts JA, Hewison M, Manolopoulos KN, et al. Mobilising vitamin D from adipose tissue: The potential impact of exercise. Nutr Bull. 2019 Mar;44(1):25-35. doi: 10.1111/nbu.12369. [DOI] [PubMed]

10. Wang S, Zhou H, Zhao C, He H. Effect of Exercise Training on Body Composition and Inflammatory Cytokine Levels in Overweight and Obese Individuals: A Systematic Review and Network Meta-Analysis. Front Immunol. 2022 Jun;13:921085. doi: 10.3389/fimmu.2022.921085. [DOI] [PubMed]

11. Zhang J, Cao ZB. Exercise: A Possibly Effective Way to Improve Vitamin D Nutritional Status. Nutrients. 2022 Jun;14(13):2652. doi: 10.3390/nu14132652. [DOI] [PubMed]

12. Pludowski P, Takacs I, Boyanov M, Belaya Z, Diaconu CC, Mokhort T, et al. Clinical Practice in the Prevention, Diagnosis and Treatment of Vitamin D Deficiency: A Central and Eastern European Expert Consensus Statement. Nutrients. 2022 Apr;14(7):1483. doi: 10.3390/nu14071483. [DOI] [PubMed]

13. Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 2013;10(2):e1001383. doi: 10.1371/journal.pmed.1001383. [DOI] [PubMed]

14. Walsh JS, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, et al. Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health. Am J Clin Nutr. 2016 Jun;103(6):1465-71. doi: 10.3945/ajcn.115.120139. [DOI] [PubMed]

15. Trim W, Turner JE, Thompson D. Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity. Front Immunol. 2018 Feb;9:169. doi: 10.3389/fimmu.2018.00169. [DOI] [PubMed]

16. Eslami Vasmaleii F, Habibian M, Moosavi SJ. [The effectiveness of vitamin D supplementation with Pilates Training on vitamin D status in overweight men. A clinical trial study]. MJMS. 2021;23(5):17-28. [Article in Persian] [Link]

17. Jafari Dolatabadi M, Habibian M. [Investigation of the Changes in Sirtuin 1 Following a Course of High-Intensity Interval Running Exercise with Vitamin D Intake in Young Women with Vitamin D Deficiency]. Iranian J Nutr Sci Food Technol. 2023;18(3):31-38. [Article in Persian] [Link]

18. Akbari R, Jafari Chashmy A, Habibian M. [The effect of eight weeks of high-intensity interval resistance training on serotonin 1 and 25-hydroxyvitamin D levels in overweight women with vitamin D deficiency]. Daneshvar Medicine, 2022;30(4):74-83. doi: 10.22070/daneshmed.2022.16123.1203. [Link] [DOI]

19. Hjinajaf S, Mohammadi F, Azizi M. [Effect of Aerobic Interval Exercise Training on Serum Levels of 25-Hydroxyvitamin D and Indices Anthropometry in Overweight and Obesity Patients]. Jundishapur Scientific Medical Journal. 2018;17(1):37-48. doi: 10.22118/jsmj.2018.59633. [Article in Persian] [Link] [DOI]

20. Hyppönen E, Boucher BJ. Adiposity, vitamin D requirements, and clinical implications for obesity-related metabolic abnormalities. Nutr Rev. 2018 Sep;76(9):678-92. doi: 10.1093/nutrit/nuy034. [DOI] [PubMed]

21. Ding C, Parameswaran V, Blizzard L, Burgess J, Jones G. Not a simple fat-soluble vitamin: Changes in serum 25-(OH)D levels are predicted by adiposity and adipocytokines in older adults. J Intern Med. 2010 Nov;268(5):501-10. doi: 10.1111/j.1365-2796.2010.02267.x. [DOI] [PubMed]

22. Mutt SJ, Hyppönen E, Saarnio J, Järvelin MR, Herzig KH. Vitamin D and adipose tissue-more than storage. Front Physiol. 2014 Jun;5:228. doi: 10.3389/fphys.2014.00228. [DOI] [PubMed]

23. Chin K, Zhao D, Tibuakuu M, Martin SS, Ndumele CE, Florido R, et al. Physical Activity, Vitamin D, and Incident Atherosclerotic Cardiovascular Disease in Whites and Blacks: The ARIC Study. J Clin Endocrinol Metab. 2017 Apr;102(4):1227-36. doi: 10.1210/jc.2016-3743. [DOI] [PubMed]

24. Marawan A, Kurbanova N, Qayyum R. Association between serum vitamin D levels and cardiorespiratory fitness in the adult population of the USA. Eur J Prev Cardiol. 2019 May;26(7):750-55. doi: 10.1177/2047487318807279. [DOI] [PubMed]

25. Chomistek AK, Chiuve SE, Jensen MK, Cook NR, Rimm EB. Vigorous physical activity, mediating biomarkers, and risk of myocardial infarction. Med Sci Sports Exerc. 2011 Oct;43(10):1884-90. doi: 10.1249/MSS.0b013e31821b4d0a. [DOI] [PubMed]

26. Moosavi J, Habibian M, Farzanegi P. [The effect of regular aerobic exercise on plasma levels of 25- hydroxy vitamin D and insulin resistance in hypertensive postmenopausal women with type 2 diabetes]. RJMS 2016;22(141):80-90. [Article in Persian] [Link]

27. Malandish A, Tartibian B, Sheikhlou Z, Afsargharehbagh R, Rahmati M. The effects of short-term moderate intensity aerobic exercise and long-term detraining on electrocardiogram indices and cardiac biomarkers in postmenopausal women. J Electrocardiol. 2020 May-Jun;60:15-22. doi: 10.1016/j.jelectrocard.2020.03.004. [DOI] [PubMed]

28. Sun X, Ma XK, Zhang L, Cao ZB. Effects of resistance training on serum 25(OH) D concentrations in young men: a randomized controlled trial. Nutr Metab (Lond). 2020; 17:59. doi: 10.1186/s12986-020-00480-w. [Link] [DOI]

29. Panissa VLG, Fukuda DH, Staibano V, Marques M, Franchini E. Magnitude and duration of excess of post-exercise oxygen consumption between high-intensity interval and moderate-intensity continuous exercise: A systematic review. Obes Rev. 2021 Jan;22(1):e13099. doi: 10.1111/obr.13099. [DOI] [PubMed]

30. Cannell JJ, Grant WB, Holick MF. Vitamin D and inflammation. Dermatoendocrinol. 2015 Jan;6(1):e983401. doi: 10.4161/19381980.2014.983401. [DOI] [PubMed]

31. Sadeghi Shirsavar H, Habibian M, Farajtabar Behrestaq S. [Effect of One Course of Pilates Training with Vitamin D supplement on Monocyte Chemoattractant Protein-1 Level and Superoxide Dismutase Activity in Overweight Men: A Clinical Trial Study]. J Gorgan Univ Med Sci. 2022;24(1):10-18. [Article in Persian] [Link]

32. Nosrati A, Askari B, Habibian M. [The effect of two month high-intensity interval training and vitamin D supplementation on the blood levels of homocysteine and total antioxidant capacity in overweight women with vitamin D deficiency. A clinical trial study]. Feyz Med Sci J.2023;27(1):67-75. doi: 10.48307/FMSJ.2023.27.1.67. [Article in Persian] [Link] [DOI]

33. Khodadoust M, Habibian M. [Investigating the Changes of Tumor Necrosis Factor-α and Interleukin-10 After 8 Weeks of Regular Pilates Exercise and Vitamin D Intake in Overweight Men: A Randomized Clinical Trial]. J Arak Uni Med Sci. 2020;23(6):888-901. doi: 10.32598/jams.23.6.3537.5. [Article in Persian] [Link] [DOI]

34. Ebrahemi Rokni F, Habibian M, Farajtabar Behrestaq S. [The Effectiveness of Pilates Training and Vitamin D Intake on the hs-CRP and TSH in Overweight Men]. Journal of Inflammatory Diseases. 2021; 25(1):31-38. [Article in Persian] [Link]

35. Li J, Liu S, Cui Y. Oxidative and Antioxidative Stress Linked Biomarkers in Ankylosing Spondylitis: A Systematic Review and Meta-analysis. Oxidative Medicine and Cellular Longevity. 2020; Article ID: 4759451. doi: 10.1155/2020/4759451. [DOI] [PubMed]

36. Simioni C, Zauli G, Martelli AM, Vitale M, Sacchetti G, Gonelli A, et al. Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget. 2018 Mar;9(24):17181-98. doi: 10.18632/oncotarget.24729. [DOI] [PubMed]

37. Alatawi FS, Faridi UA, Alatawi MS. Effect of treatment with vitamin D plus calcium on oxidative stress in streptozotocin-induced diabetic rats. Saudi Pharm J. 2018 Dec;26(8):1208-13. doi: 10.1016/j.jsps.2018.07.012. [DOI] [PubMed]

38. Jain SK, Parsanathan R, Achari AE, Kanikarla-Marie P, Bocchini JA Jr. Glutathione Stimulates Vitamin D Regulatory and Glucose-Metabolism Genes, Lowers Oxidative Stress and Inflammation, and Increases 25-Hydroxy-Vitamin D Levels in Blood: A Novel Approach to Treat 25-Hydroxyvitamin D Deficiency. Antioxid Redox Signal. 2018 Dec;29(17):1792-807. doi: 10.1089/ars.2017.7462. [DOI] [PubMed]

39. Azimzadeh MJ, Shidfarc F, Jazayerie S, Hosseinif AF, Ranjbaran F. Effect of vitamin D supplementation on klotho protein, antioxidant status and nitric oxide in the elderly: A randomized, double-blinded, placebo-controlled clinical trial. European Journal of Integrative Medicine. 2020 Apr;35:101089. doi: 10.1016/j.eujim.2020.101089. [Link] [DOI]

40. Kalvandi F, Azarbayjani MA, Azizbeigi R, Azizbeigi K. Elastic resistance training is more effective than vitamin D3 supplementation in reducing oxidative stress and strengthen antioxidant enzymes in healthy men. Eur J Clin Nutr. 2022 Apr;76(4):610-15. doi: 10.1038/s41430-021-01000-6. [DOI] [PubMed]

41. Keshvari R, Habibian M, Askari B. [The Effect of High-Intensity Interval Training with Vitamin D Intake on Interleukin-10 and Lipid Peroxidation Levels in Overweight Women with Low Vitamin D Status: A Randomized Clinical Trial]. RJMS. 2023;30(3):36-47. [Article in Persian] [Link]

42. Akbari R, Jafari Chashmy A, Habibian M. [The Effect of Sports Activity and Vitamin D Intake on Serum Eutoxin-1 and Superoxide Dismutase Levels in Overweight Women with Vitamin D Deficiency: A Clinical Trial Study]. North Khorasan University of Medical Sciences. 2023;15(1):34-42. doi: 10.32592/nkums.15.1.34. [Article in Persian] [Link] [DOI]

43. Ye Y, Lin H, Wan M, Qiu P, Xia R, He J, et al. The Effects of Aerobic Exercise on Oxidative Stress in Older Adults: A Systematic Review and Meta-Analysis. Front Physiol. 2021 Oct;12:701151. doi: 10.3389/fphys.2021.701151. [DOI] [PubMed]

44. Mattson MP. Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders. Exp Gerontol. 2009 Oct;44(10):625-33. doi: 10.1016/j.exger.2009.07.003. [DOI] [PubMed]

45. Migliaccio S, Di Nisio A, Mele C, Scappaticcio L, Savastano S, Colao A. Obesity and hypovitaminosis D: causality or casualty? Int J Obes Suppl. 2019 Apr;9(1):20-31. doi: 10.1038/s41367-019-0010-8. [DOI] [PubMed]

46. Sabir MS, Khan Z, Hu C, Galligan MA, Dussik CM, Mallick S, et al. SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation. J Steroid Biochem Mol Biol. 2017 Sep;172:117-29. doi: 10.1016/j.jsbmb.2017.06.010. [DOI] [PubMed]

47. You T, Arsenis NC, Disanzo BL, Lamonte MJ. Effects of exercise training on chronic inflammation in obesity : current evidence and potential mechanisms. Sports Med. 2013 Apr;43(4):243-56. doi: 10.1007/s40279-013-0023-3. [DOI] [PubMed]

48. Huang CJ, McAllister MJ, Slusher AL, Webb HE, Mock JT, Acevedo EO. Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation. Sports Med Open. 2015;1(1):32. doi: 10.1186/s40798-015-0031-y. [DOI] [PubMed]

49. Palaniswamy S, Gill D, De Silva NM, Lowry E, Jokelainen J, Karhu T, et al. Could vitamin D reduce obesity-associated inflammation? Observational and Mendelian randomization study. Am J Clin Nutr. 2020 May;111(5):1036-47. doi: 10.1093/ajcn/nqaa056. [DOI] [PubMed]

50. Krajewska M, Witkowska-Sędek E, Rumińska M, Stelmaszczyk-Emmel A, Sobol M, Majcher A, et al. Vitamin D Effects on Selected Anti-Inflammatory and Pro-Inflammatory Markers of Obesity-Related Chronic Inflammation. Front Endocrinol (Lausanne). 2022 Jun;13:920340. doi: 10.3389/fendo.2022.920340. [DOI] [PubMed]

51. Timpson NJ, Nordestgaard BG, Harbord RM, Zacho J, Frayling TM, Tybjærg-Hansen A, et al. C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. Int J Obes (Lond). 2011 Feb;35(2):300-308. doi: 10.1038/ijo.2010.137. [DOI] [PubMed]

52. Rafiq R, El Haddaoui H, de Mutsert R, Rosendaal FR, Hiemstra PS, Cobbaert CM, et al. Adiposity is a confounding factor which largely explains the association of serum vitamin D concentrations with C-reactive protein, leptin and adiponectin. Cytokine. 2020 Jul;131:155104. doi: 10.1016/j.cyto.2020.155104. [DOI] [PubMed]

53. Amirkhizi F, Pishdadian A, Asghari S, Hamedi-Shahraki S. Vitamin D status is favorably associated with the cardiovascular risk factors in adults with obesity. Clin Nutr ESPEN. 2021 Dec;46:232-39. doi: 10.1016/j.clnesp.2021.10.003. [DOI] [PubMed]

54. Nazarabadi PN, Etemad Z, Hoseini R, Moradi F. Anti-Inflammatory Effects of a Period of Aerobic Training and Vitamin D Supplementation in Postmenopausal Women with Metabolic Syndrome. Int J Prev Med. 2022 Apr;13:60. doi: 10.4103/ijpvm.IJPVM_312_20. [DOI] [PubMed]

55. Akbari R, Jafari Chashmi A, Habibian M. [The Effect of High Intensity Interval Resistance Training and Vitamin D Supplementation on Sirtuin1 and Interleukin-10 levels in Overweight Women with Low Vitamin D Status]. Medical Journal of Mashhad University of Medical Sciences. 2023;66(2):178-88. doi: 10.22038/mjms.2022.65428.3842. [Article in Persian] [Link] [DOI]

56. Vella CA, Taylor K, Drummer D. High-intensity interval and moderate-intensity continuous training elicit similar enjoyment and adherence levels in overweight and obese adults. Eur J Sport Sci. 2017 Oct;17(9):1203-11. doi: 10.1080/17461391.2017.1359679. [DOI] [PubMed]

57. Pedersen BK. Muscles and their myokines. J Exp Biol. 2011 Jan;214(Pt 2):337-46. doi: 10.1242/jeb.048074. [DOI] [PubMed]

58. Singh S, Anshita D, Ravichandiran V. MCP-1: Function, regulation, and involvement in disease. Int Immunopharmacol. 2021 Dec;101(Pt B):107598. doi: 10.1016/j.intimp.2021.107598. [DOI] [PubMed]

59. Harakeh S, Kalamegam G, Pushparaj PN, Al-Hejin A, Alfadul SM, Al Amri T, et al. Chemokines and their association with body mass index among healthy Saudis. Saudi J Biol Sci. 2020 Jan;27(1):6-11. doi: 10.1016/j.sjbs.2019.03.006. [DOI] [PubMed]

60. Breslin WL, Johnston CA, Strohacker K, Carpenter KC, Davidson TR, Moreno JP, et al. Obese Mexican American children have elevated MCP-1, TNF-α, monocyte concentration, and dyslipidemia. Pediatrics. 2012 May;129(5):e1180-6. doi: 10.1542/peds.2011-2477. [DOI] [PubMed]

61. Kim CS, Park HS, Kawada T, Kim JH, Lim D, Hubbard NE, et al. Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. Int J Obes (Lond). 2006 Sep;30(9):1347-55. doi: 10.1038/sj.ijo.0803259. [DOI] [PubMed]

62. Hashimoto I, Wada J, Hida A, Baba M, Miyatake N, Eguchi J, et al. Elevated serum monocyte chemoattractant protein-4 and chronic inflammation in overweight subjects. Obesity (Silver Spring). 2006 May;14(5):799-811. doi: 10.1038/oby.2006.93. [DOI] [PubMed]

63. Vasudevan AR, Wu H, Xydakis AM, Jones PH, Smith EO, Sweeney JF, et al. Eotaxin and obesity. J Clin Endocrinol Metab. 2006 Jan;91(1):256-61. doi: 10.1210/jc.2005-1280. [DOI] [PubMed]

64. Goltz A, Janowitz D, Hannemann A, Nauck M, Hoffmann J, Seyfart T, et al. Association of Brain-Derived Neurotrophic Factor and Vitamin D with Depression and Obesity: A Population-Based Study. Neuropsychobiology. 2017;76(4):171-81. doi: 10.1159/000489864. [DOI] [PubMed]

65. Bischoff-Ferrari HA, Dawson-Hughes B, Stöcklin E, Sidelnikov E, Willett WC, Edel JO, et al. Oral supplementation with 25(OH)D3 versus vitamin D3: effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity. J Bone Miner Res. 2012 Jan;27(1):160-69. doi: 10.1002/jbmr.551. [DOI] [PubMed]

66. Lotfi-Dizaji L, Mahboob S, Aliashrafi S, Vaghef-Mehrabany E, Ebrahimi-Mameghani M, Morovati A. Effect of vitamin D supplementation along with weight loss diet on meta-inflammation and fat mass in obese subjects with vitamin D deficiency: A double-blind placebo-controlled randomized clinical trial. Clin Endocrinol (Oxf). 2019 Jan;90(1):94-101. doi: 10.1111/cen.13861. [DOI] [PubMed]

67. Cho SY, Roh HT. Effects of aerobic exercise training on peripheral brain-derived neurotrophic factor and eotaxin-1 levels in obese young men. J Phys Ther Sci. 2016 Apr;28(4):1355-58. doi: 10.1589/jpts.28.1355. [DOI] [PubMed]

68. Fekri Kourabbaslou V, Motamedi P, Amani Shalamzari S. [The effect of six weeks of interval resistance training on eotaxin and brain-derived neurotrophic factor serum levels in overweight young men]. Research in Sport Medicine and Technology. 2018;16(15):23-34. [Article in Persian] [Link]

69. Roh HT, Cho SY, So WY. A Cross-Sectional Study Evaluating the Effects of Resistance Exercise on Inflammation and Neurotrophic Factors in Elderly Women with Obesity. J Clin Med. 2020 Mar;9(3):842. doi: 10.3390/jcm9030842. [DOI] [PubMed]

70. Habibian M, Farzanegi P, Sadat Tabar Bisheh SM. [The Combined Effects of Pilates Training and Apium Graveolens Seed Supplement on the Levels of Inflammatory Monocyte Chemoattractant Protein -1 and C-Reactive Protein in Sedentary Women]. J Arak Uni Med Sci. 2015;18(9):39-48. [Article in Persian] [Link]

71. Dehghankar L, Gholami M, Ghazalian F. [Effects of 8 weeks combined training along with Zataria Multiflora supplement ingestion on serum levels of MCP-1 and insulin resistance in overweight men]. Journal of Practical Studies of Biosciences in Sport. 2020;8(16):34-46. doi: 10.22077/jpsbs.2019.1956.1450. [Article in Persian] [Link] [DOI]

72. Rai V, Agrawal DK. Role of Vitamin D in Cardiovascular Diseases. Endocrinol Metab Clin North Am. 2017 Dec;46(4):1039-59. doi: 10.1016/j.ecl.2017.07.009. [DOI] [PubMed]

73. Gao D, Trayhurn P, Bing C. 1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes. Int J Obes (Lond). 2013 Mar;37(3):357-65. doi: 10.1038/ijo.2012.53. [DOI] [PubMed]

74. Wang LF, Chien CY, Tai CF, Chiang FY, Chen JY. Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps. Kaohsiung J Med Sci. 2015 Feb;31(2):63-69. doi: 10.1016/j.kjms.2014.11.011. [DOI] [PubMed]

75. Dieli-Conwright CM, Parmentier JH, Sami N, Lee K, Spicer D, Mack WJ, et al. Adipose tissue inflammation in breast cancer survivors: effects of a 16-week combined aerobic and resistance exercise training intervention. Breast Cancer Res Treat. 2018 Feb;168(1):147-57. doi: 10.1007/s10549-017-4576-y. [DOI] [PubMed]