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Anti-Fungal Effects of Aerial Part Extracts of Artemisia biennis, Artemisia ciniformis, and Artemisia turanica
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Ali Mikaeili1    , Samira Ghasemi2 , Nastaran Ghiasvand3 , Abdolmajid Valadbeigi4 , Mahdi Mojarrab * 5 |
1- Professor of Mycology, Department of Parasitology and Mycology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2- Ph.D in Plant Pathology, Department of Plant Pathology, Faculty of Agriculture, Kurdistan University, Sanandaj, Iran.
3- M.Sc in Plant Physiology, Pharmaceutical Sciences Research Center, Research Institute for Health, Kermanshash University of Medical Sciences, Kermanshah, Iran.
4- Doctor of Pharmacy, Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
5- Associate Professor of Pharmacognosy, Pharmaceutical Sciences Research Center, Research Institute for Health, Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran. , mmojarrab@kums.ac.ir |
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Abstract: (2682 Views) |
Background and Objective: Dermatophytosis is a significant skin disease in both humans and animals. Its resistance to common treatments is on the rise. Allylamines, polyenes, and azoles are prominent groups of anti-fungal drugs used to treat dermatophytosis. Various species of Artemisia, which are widely distributed in Iran, are regarded as a rich source of natural compounds with valuable biological activities. This research aimed to determine the anti-fungal effects of aerial part extracts of Artemisia biennis, Artemisia ciniformis, and Artemisia turanica.
Methods: This descriptive study examined the petroleum ether, dichloromethane, ethyl acetate, ethanolic, and hydroalcoholic aerial part extracts of Artemisia biennis, Artemisia ciniformis, and Artemisia turanica against fungi causing dermatophytosis. The investigated fungi included Trichophyton rubrum, Trichophyton verrucosum, Epidermophyton floccosum, and Microsporum cannis. The minimum inhibitory concentration (MIC) test was performed based on the agar dilution method. The most active extracts were investigated in preliminary phytochemical tests.
Results: In the initial screening, Epidermophyton floccosum and Microsporum cannis exhibited the highest resistance (11 out of 15) and sensitivity (12 out of 15), respectively, to the tested extracts. Petroleum ether extracts from all three Artemisia species were the most active extracts used in the tests. Hydroalcoholic extracts showed the least anti-dermatophytic activity. The lowest MIC (78.1 μg/mL) was recorded for the petroleum ether extract of Artemisia ciniformis against Trichophyton rubrum. Preliminary phytochemical studies showed the common presence of terpenoids in all plant species extracts.
Conclusion: Some lipophilic compounds present in petroleum ether extracts of Artemisia biennis and Artemisia ciniformis, as well as dichloromethane extract of Artemisia biennis, exhibited significant in vitro anti-dermatophytic activities.
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Keywords: Artemisia [MeSH], Antifungal Agents [MeSH], Dermatophytes [MeSH]
Article ID: Vol26-39 |
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Full-Text [PDF 715 kb]
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Type of Study: Original Articles |
Subject:
Medical Mycology
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Mikaeili A, Ghasemi S, Ghiasvand N, Valadbeigi A, Mojarrab M. Anti-Fungal Effects of Aerial Part Extracts of Artemisia biennis, Artemisia ciniformis, and Artemisia turanica. J Gorgan Univ Med Sci 2024; 26 (4) :70-77 URL: http://goums.ac.ir/journal/article-1-4447-en.html
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