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Evaluation of Hepatotoxicity of Alpinia officinarum Rhizomes Aqueous Extract in Male Wistar Rats
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Vakil Nadimi1    , Shohreh Taziki * 2, Fatemeh Kolangi3 , Mohammad Mazandarani4 , Zahra Memariani5 |
1- Medical Student, Ischemic Disorders Research Center, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
2- Assistant Professor, Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Assistant Professor, Department of Pharmacology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. , dr_sh_taziki@yahoo.com
3- Assistant Professor, Counseling and Reproductive Health Research Centre, Golestan University of Medical Sciences, Gorgan, Iran. Assistant Professor, Department of Traditional Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
4- Associate Professor, Faculty of Fisheries and Environment, Golestan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
5- Assistant Professor, Traditional Medicine and History of Medicine Science Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Assistant Professor, Department of Traditional Medicine, Babol University of Medical Sciences, Babol, Iran. |
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Abstract: (3188 Views) |
Background and Objective: The liver is the main organ involved in the metabolism of various drugs and toxins. Thus, it is highly vulnerable to damage caused by drugs and toxins. Alpinia officinarum belongs to the Ginger family and has been used in traditional Iranian medicine for its therapeutic effects on the digestive system, including strengthening the function of the stomach and organs, improving digestion and reducing bloating. In addition, the plant has anti-hyperlipidemic, anti-inflammatory, antiviral, antibacterial, anticancer and antioxidant properties. This study investigated the hepatotoxic effects of Alpinia officinarum rhizomes aqueous extract in male Wistar rats.
Methods: This experimental study was performed on 35 male Wistar rats that were randomly allocated into 5 groups of 7. Four groups received 100, 200, 400 and 800 mg/kg of the extract for 28 days, while a group did not receive the extract (control group). Tissue sections (5 microns) were stained by hematoxylin and eosin at the pharmacology laboratory of Golestan University of Medical Sciences. The groups were examined for liver tissue pathology, and the level of liver enzymes including aspartate aminotransferase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) was measured by Pars Azmoun ELISA kit.
Results: Administration of the aqueous extract of Alpinia officinarum rhizome for 28 days by gavage increased the level of AST, ALT and ALP in the serum of rats. Tissue damage was observed in most groups receiving the extract.
Conclusion: The results show that consumption of the aqueous extract of Alpinia officinarum rhizome at a dose of more than 100 mg/kg can cause liver damage and is lethal at a dose of 800 mg/kg.
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Keywords: Alpinia [MeSH], Liver [MeSH], Aspartate Aminotransferase [MeSH], Alanine Transaminase [MeSH], Alkaline Phosphatase [MeSH], Rats [MeSH]
Article ID: Vol24-33 |
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Full-Text [PDF 1176 kb]
(9253 Downloads)
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Type of Study: Original Articles |
Subject:
Physiology - Pharmacology
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| References |
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Nadimi V, Taziki S, Kolangi F, Mazandarani M, Memariani Z. Evaluation of Hepatotoxicity of Alpinia officinarum Rhizomes Aqueous Extract in Male Wistar Rats. J Gorgan Univ Med Sci 2022; 24 (3) :34-40 URL: http://goums.ac.ir/journal/article-1-4073-en.html
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