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Effect of Lidocaine, Magnesium Sulfate and Ketamine on the Pain of Propofol Intravenous Injection in Patients Undergoing Surgery: A Clinical Trial Study
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Seyedeh Mahrokh Alinaghimaddah *    1, Payman Asghari2 , Amir Hosein Mohammad Shafiee3 , Fatemeh Mehravar4 , Mohammad Aryaie5 |
1- Assistant Professor of Anesthesiology, Department of Anesthesiology and Critical Care, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. , mitramaddah2000@yahoo.com
2- Anesthesiologist, Imam Sajad Hospital, Mazandaran University of Medical Sciences, Ramsar, Iran.
3- Medical Student, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
4- Ph.D Candidate in Epidemiology, School of Public Health. Tehran University of Medical Sciences, Tehran, Iran.
5- Assistant Professor of Epidemiology, Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran. |
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Abstract: (2767 Views) |
Background and Objective: Propofol is one of the most commonly used drugs in anesthesia with the pain during an injection is a side effect of this drug. This study was conducted to compare the effect of Lidocaine, Magnesium Sulfate, and Ketamine on reducing pain caused by intravenous injection of Propofol in patients Undergoing surgery.
Methods: In this double-blind randomized clinical trial study, 80 patients aged 18 to 65 years were randomly blocked and assigned into four groups including Lidocaine, Ketamine, Magnesium Sulfate and Normal Saline. The pain was measured with the Ambesh Score. Hemodynamic changes of patients were evaluated in 1, 3, and 5 minutes.
Results: The patients in Lidocaine, Ketamine, and Magnesium Sulfate groups with 75%, 70%, and 55%, respectively, did not feel pain after Propofol injection compared to Normal Saline group (25%) (P<0.05). The mean time trend of Systolic and diastolic blood pressure and mean arterial blood pressure between the studied groups were significant (P<0.05).
Conclusion: The use of Lidocaine or Ketamine during Propofol injection can be effective in reducing pain during injection in patients undergo surgery. |
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Keywords: Propofol [MeSH], Lidocaine [MeSH], Magnesium Sulfate [MeSH], Ketamine [MeSH], Pain [MeSH], General Anesthesia [MeSH]
Article ID: Vol24-03 |
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Full-Text [PDF 590 kb]
(9087 Downloads)
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Type of Study: Original Articles |
Subject:
Anesthesiology and Pain
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Alinaghimaddah S M, Asghari P, Mohammad Shafiee A H, Mehravar F, Aryaie M. Effect of Lidocaine, Magnesium Sulfate and Ketamine on the Pain of Propofol Intravenous Injection in Patients Undergoing Surgery: A Clinical Trial Study. J Gorgan Univ Med Sci 2022; 24 (1) :19-25 URL: http://goums.ac.ir/journal/article-1-4059-en.html
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