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Effect of Vitamin D on Lung Function, Serum Immunoglobulin E and Total Antioxidant Capacity in Asthma Patients: A Clinical Trial
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Sayyed Gholamreza Mortazavi Moghaddam1    , Asghar Zarban2 , Ali Mirshahi * 3 |
1- Assistant Professor of Internal Medicine, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
2- Professor of Biochemistry, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
3- Internist, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran. , oabstudent@gmail.com |
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Abstract: (1789 Views) |
Background and Objective: Asthma is a chronic airway disorder with a rising prevalence. Dietary factors, antioxidant indicators and vitamin D deficiency are associated with the disease. Due to the presence of receptors for this vitamin in the lung, this study aimed to investigate the effects of vitamin D administration on lung function, serum immunoglobulin E (IgE) level and total serum antioxidant activity in patients with moderate to severe asthma.
Methods: In this clinical trial, 60 patients with asthma were randomly divided into two groups: a control group (placebo recipient) and an intervention group (recipient of 2,000 vitamin D capsules for 12 weeks). At the beginning and at the end of the study, 5 cc blood samples were taken from each patient, and spirometry test was performed. Total antioxidant capacity (TAC), IgE and vitamin D parameters were measured.
Results: The mean score of forced expiratory volume (FEV1) and FEV1/FVC in both groups as well as the mean FVC in the control group did not change significantly after the intervention. The mean FVC score, vitamin D level and TAC in the intervention group increased significantly after the intervention, while the IgE levels reduced significantly.
Conclusion: Taking vitamin D tablets could increase the antioxidant parameters in asthmatic patients.
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Keywords: Asthma [MeSH], Vitamin D [MeSH], Immunoglobulin E [MeSH]
Article ID: Vol24-29 |
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Full-Text [PDF 786 kb]
(8023 Downloads)
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Type of Study: Original Articles |
Subject:
Internal Medicine
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Mortazavi Moghaddam S G, Zarban A, Mirshahi A. Effect of Vitamin D on Lung Function, Serum Immunoglobulin E and Total Antioxidant Capacity in Asthma Patients: A Clinical Trial. J Gorgan Univ Med Sci 2022; 24 (3) :1-7 URL: http://goums.ac.ir/journal/article-1-4040-en.html
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