[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Indexing Sources::
Editorial Board::
Executive Members::
Articles Archive::
Instruction to Authors::
Contact Us::
Site Facilities::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 22, Issue 4 (12-2020) ::
J Gorgan Univ Med Sci 2020, 22(4): 54-62 Back to browse issues page
Effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A
Farhad Pashazadeh1 , Asghar Tofighi * 2, Siyamak Asri Rezaei3 , Javad Tolouei Azar4
1- Ph.D Candidate in Exercise Physiology, Department of Exercise Physiology and Corrective Exercise, Faculty of Sport Sciences, Urmia University, Urmia, Iran.
2- Associate Professor, Department of Exercise Physiology and Corrective Exercise, Faculty of Sport Sciences, Urmia University, Urmia, Iran. , a.tofighi@urmia.ac.ir
3- Associate Professor, Department of Internal Diseases and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
4- Assistant Professor, Department of Exercise Physiology and Corrective Exercise, Faculty of Sport Sciences, Urmia University, Urmia, Iran.
Abstract:   (6628 Views)
Background and Objective: Bisphenol A (BPA) is the monometer of epoxy resins and polycarbonate plastics that plays an important role in the pathogenesis of cardiovascular diseases. This study was done to evaluate the effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A.
Methods: In this experimental study, 20 adult male Wistar rats were allocated into four groups including control, aerobic exercise, BPA and BPA + aerobic exercise. Animals in control and aerobic exercise groups were receieved olive oil and the BPA (100 μg/kg) intraperitoneally, respectively. Animals in BPA + aerobic training group were treated with BPA (100 μg/kg) intraperitoneally for 30 days. Exercise program consisted of 25-64 minutes of running with 57-75% oxygen consumption, 5 sessions per week for two months. Indicators of oxidative stress in heart tissue including Gpx, SOD, TAC, MDA, CAT and AOPP were evaluated.
Results: BPA intoxication induced a significant increase in the activity of SOD , GPX enzymes, AOPP and MDA levels and  reduction  in CAT enzyme activity and TAC level in compared to control group (P<0.05). While aerobic exercise could diminish the oxidative stress due to BPA intoxication. Aerobic exercise reduced the activity of the GPX, SOD and increased catalase activity in rats with BPA intoxication (P<0.05). Also, level of MDA and AOPP significantly reduced in in aerobic exercise group in comparison with with BPA intoxication (P<0.05).
Conclusion: Aerobic exercise activity has moderating effects on BPA intoxication in cardiac oxidative stress. Aerobic exercise can increase the amount of antioxidant enzymes that play an important role in modulating oxidative stress induced by BPA.
Keywords: Bisphenol A , Exercise [MeSH], Oxidative Stress [MeSH], Heart [MeSH]
Article ID: Vol22-54
Full-Text [PDF 297 kb]   (8685 Downloads)    
Type of Study: Original Articles | Subject: Exercise Physiology
1. Muhamad MS, Salim MR, Lau WJ, Yusop Z. A review on bisphenol A occurrences, health effects and treatment process via membrane technology for drinking water. Environ Sci Pollut Res Int. 2016 Jun; 23(12): 11549-67. DOI: 10.1007/s11356-016-6357-2 [DOI] [PubMed]
2. Kawagoshi Y, Fujita Y, Kishi I, Fukunaga I. Estrogenic chemicals and estrogenic activity in leachate from municipal waste landfill determined by yeast two-hybrid assay. J Environ Monit. 2003 Apr; 5(2): 269-74. DOI: 10.1039/b210962j [DOI] [PubMed]
3. Mourad IM, Khadrawy YA. The sensetivity of liver, kidney andtestis of rats to oxidative stress induced by different doses of bisphenol A. Int J Life Sci Pharma Res. 2012; 2(2): 19-28. [Article]
4. Bindhumol V, Chitra KC, Mathur PP. Bisphenol A induces reactive oxygen species generation in the liver of male rats. Toxicology. 2003 Jun; 188(2-3): 117-24. DOI: 10.1016/s0300-483x(03)00056-8 [DOI] [PubMed]
5. Khodayar MJ, Kalantari H, Mahdavinia M, Khorsandi L, Alboghobeish S, Samimi A, et al. Protective effect of naringin against BPA-induced cardiotoxicity through prevention of oxidative stress in male Wistar rats. Drug Chem Toxicol. 2020 Jan; 43(1): 85-95. DOI: 10.1080/01480545.2018.1504958 [DOI] [PubMed]
6. Aboul Ezz HS, Khadrawy YA, Mourad IM. The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats. Cytotechnology. 2015 Jan; 67(1): 145-55. DOI: 10.1007/s10616-013-9672-1 [DOI] [PubMed]
7. Asano S, Tune JD, Dick GM. Bisphenol A activates Maxi-K (KCa1.1) channels in coronary smooth muscle. Br J Pharmacol. 2010 May; 160(1): 160-70. DOI: 10.1111/j.1476-5381.2010.00687.x [DOI] [PubMed]
8. Vieira Junior RC, Santos Silva CM, de Araújo MB, Garcia A, Voltarelli VA, dos Reis Filho AD, et al. Aerobic swimming Training increases the activity of antioxidant enzymes and the glycogen content in the skeletal muscle of rats. Rev Bras Med Esporte. 2013 Jun; 19(3): 204-208. [Article]
9. Hyatt HW, Smuder AJ, Sollanek KJ, Morton AB, Roberts MD, Kavazis AN. Comparative changes in antioxidant enzymes and oxidative stress in cardiac, fast twitch and slow twitch skeletal muscles following endurance exercise training. Int J Physiol Pathophysiol Pharmacol. 2016; 8(4): 160-68. [PubMed]
10. Škvařilová M, Bulava A, Stejskal D, Adamovská S, Bartek J. Increased level of advanced oxidation products (AOPP) as a marker of oxidative stress in patients with acute coronary syndrome. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Jun; 149(1): 83-87. [PubMed]
11. Naderi R, Mohaddes G, Mohammadi M, Ghaznavi R, Ghyasi R, Vatankhah AM. Voluntary exercise protects heart from oxidative stress in diabetic rats. Adv Pharm Bull. 2015 Jun; 5(2): 231-36. DOI: 10.15171/apb.2015.032 [DOI] [PubMed]
12. Bernhart FW, Tomarelli RM. A salt mixture supplying the National Research Council estimates of the mineral requirements of the rat. J Nutr. 1966 Aug; 89(4): 495-500. DOI: 10.1093/jn/89.4.495 [DOI] [PubMed]
13. Batista TM, Alonso-Magdalena P, Vieira E, Amaral ME, Cederroth CR, Nef S, et al. Short-term treatment with bisphenol-A leads to metabolic abnormalities in adult male mice. PLoS One. 2012; 7(3): e33814. DOI: 10.1371/journal.pone.0033814 [DOI] [PubMed]
14. Tarafder P, Sarkar K, Nath PP, Paul G. Inhibition of heart ventricular function of rat by bisphenol A through oxidative stress induced injury of ventricular tissue. Int J Pharm Bio Sci. 2013; 4(2): 811-20. [Article]
15. Hosseinzadeh S, Dabidi Roshan V, Mahjoub S, Taghipour Darzi M. [The Interactive Effect of Lead Acetate and Endurance Training on the Brain-Derived Neurotrophic Factor and Malondialdehyde Levels in Rats Cortex]. J Babol Univ Med Sci. 2012; 14(2): 7-15. [Article in Persian] [Article]
16. Nair V, Turner GA. The thiobarbituric acid test for lipid peroxidation: structure of the adduct with malondialdehyde. Lipids. 1984; 19(10): 804-805. DOI: 10.1007/BF02534475 [Article] [DOI]
17. Witko V, Nguyen AT, Descamps-Latscha B. Microtiter plate assay for phagocyte-derived taurine-chloramines. J Clin Lab Anal. 1992; 6(1): 47-53. DOI: 10.1002/jcla.1860060110 [DOI] [PubMed]
18. Ribeiro-Samora GA, Rabelo LA, Ferreira AC, Favero M, Guedes GS, Pereira LS, et al. Inflammation and oxidative stress in heart failure: effects of exercise intensity and duration. Braz J Med Biol Res. 2017 Aug; 50(9): e6393. DOI: 10.1590/1414-431X20176393 [DOI] [PubMed]
19. Gouraud E, Charrin E, Dubé JJ, Ofori-Acquah SF, Martin C, Skinner S, et al. Effects of Individualized Treadmill Endurance Training on Oxidative Stress in Skeletal Muscles of Transgenic Sickle Mice. Oxid Med Cell Longev. 2019 Jul; 2019: 3765643. DOI: 10.1155/2019/3765643 [DOI] [PubMed]
20. Cunningham P, Geary M, Harper R, Pendleton A, Stover S. High Intensity Sprint Training Reduces Lipid Peroxidation In Fast-Twitch Skeletal Muscle. J Exerc Physiolo Online. 2005; 8(6): 18-25. [Article]
21. Chevion S, Moran DS, Heled Y, Shani Y, Regev G, Abbou B, et al. Plasma antioxidant status and cell injury after severe physical exercise. Proc Natl Acad Sci U S A. 2003 Apr; 100(9): 5119-23. DOI: 10.1073/pnas.0831097100 [DOI] [PubMed]
22. da Palma RK, Moraes-Silva IC, da Silva Dias D, Shimojo GL, Conti FF, Bernardes N, et al. Resistance or aerobic training decreases blood pressure and improves cardiovascular autonomic control and oxidative stress in hypertensive menopausal rats. J Appl Physiol. 2016 Oct; 121(4): 1032-38. DOI: 10.1152/japplphysiol.00130.2016 [Article] [DOI]
23. Jolitha AB, Subramanyam MV, Devi SA. Modification by vitamin E and exercise of oxidative stress in regions of aging rat brain: studies on superoxide dismutase isoenzymes and protein oxidation status. Exp Gerontol. 2006 Aug; 41(8): 753-63. DOI: 10.1016/j.exger.2006.04.007 [DOI] [PubMed]
24. Gorzi A, Tofighi A, Amiri B. [The effects of curcumin supplementation on oxidative stress induced during strenuous endurance training on the kidney and lung tissues]. Scientific J Kurdistan Univ Med sci. 2018; 23(5): 1-11. [Article in Persian] [View at Publisher]
25. Ighodaro OM, Akinloye OA. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria J Med. 2018 Dec; 54(4): 287-93. DOI: 10.1016/j.ajme.2017.09.001 [Article] [DOI]
26. Hassan ZK, Elobeid MA, Virk P, Omer SA, ElAmin M, Daghestani MH, et al. Bisphenol A induces hepatotoxicity through oxidative stress in rat model. Oxid Med Cell Longev. 2012; 2012: 194829. DOI: 10.1155/2012/194829 [DOI] [PubMed]
27. Tiwari D, Vanage G. Bisphenol A induces oxidative stress in bone marrow cells, lymphocytes, and reproductive organs of Holtzman rats. Int J Toxicol. 2017; 36(2): 142-52. DOI: 10.1177/1091581817691224 [Article] [DOI]
28. Fridovich I. Superoxide anion radical (O-2), superoxide dismutases, and related matters. J Biol Chem. 1997 Jul; 272(30): 18515-17. DOI: 10.1074/jbc.272.30.18515 [DOI] [PubMed]
Send email to the article author

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Pashazadeh F, Tofighi A, Asri Rezaei S, Tolouei Azar J. Effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A. J Gorgan Univ Med Sci 2020; 22 (4) :54-62
URL: http://goums.ac.ir/journal/article-1-3726-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 22, Issue 4 (12-2020) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 36 queries by YEKTAWEB 4652