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:: Volume 22, Issue 4 (12-2020) ::
J Gorgan Univ Med Sci 2020, 22(4): 54-62 Back to browse issues page
Effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A
Farhad Pashazadeh1 , Asghar Tofighi * 2, Siyamak Asri Rezaei3 , Javad Tolouei Azar4
1- Ph.D Candidate in Exercise Physiology, Department of Exercise Physiology and Corrective Exercise, Faculty of Sport Sciences, Urmia University, Urmia, Iran.
2- Associate Professor, Department of Exercise Physiology and Corrective Exercise, Faculty of Sport Sciences, Urmia University, Urmia, Iran. , a.tofighi@urmia.ac.ir
3- Associate Professor, Department of Internal Diseases and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
4- Assistant Professor, Department of Exercise Physiology and Corrective Exercise, Faculty of Sport Sciences, Urmia University, Urmia, Iran.
Abstract:   (6628 Views)
Background and Objective: Bisphenol A (BPA) is the monometer of epoxy resins and polycarbonate plastics that plays an important role in the pathogenesis of cardiovascular diseases. This study was done to evaluate the effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A.
Methods: In this experimental study, 20 adult male Wistar rats were allocated into four groups including control, aerobic exercise, BPA and BPA + aerobic exercise. Animals in control and aerobic exercise groups were receieved olive oil and the BPA (100 μg/kg) intraperitoneally, respectively. Animals in BPA + aerobic training group were treated with BPA (100 μg/kg) intraperitoneally for 30 days. Exercise program consisted of 25-64 minutes of running with 57-75% oxygen consumption, 5 sessions per week for two months. Indicators of oxidative stress in heart tissue including Gpx, SOD, TAC, MDA, CAT and AOPP were evaluated.
Results: BPA intoxication induced a significant increase in the activity of SOD , GPX enzymes, AOPP and MDA levels and  reduction  in CAT enzyme activity and TAC level in compared to control group (P<0.05). While aerobic exercise could diminish the oxidative stress due to BPA intoxication. Aerobic exercise reduced the activity of the GPX, SOD and increased catalase activity in rats with BPA intoxication (P<0.05). Also, level of MDA and AOPP significantly reduced in in aerobic exercise group in comparison with with BPA intoxication (P<0.05).
Conclusion: Aerobic exercise activity has moderating effects on BPA intoxication in cardiac oxidative stress. Aerobic exercise can increase the amount of antioxidant enzymes that play an important role in modulating oxidative stress induced by BPA.
Keywords: Bisphenol A , Exercise [MeSH], Oxidative Stress [MeSH], Heart [MeSH]
Article ID: Vol22-54
Full-Text [PDF 297 kb]   (8685 Downloads)    
Type of Study: Original Articles | Subject: Exercise Physiology
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Pashazadeh F, Tofighi A, Asri Rezaei S, Tolouei Azar J. Effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A. J Gorgan Univ Med Sci 2020; 22 (4) :54-62
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Volume 22, Issue 4 (12-2020) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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