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:: Volume 22, Issue 2 (6-2020) ::
J Gorgan Univ Med Sci 2020, 22(2): 104-109 Back to browse issues page
Etiologic factors of Candida vulvovaginitis in pregnant women
Sousan Mohammadi1 , Fatemeh Keshavarzi * 2, Behnaz Manouchehri3 , Fariba Lahoorpour4 , Mohammad Raza Javaheri5
1- M.Sc in Microbiology, Department of Biology, Kurdistan Science and Research Branch, Islamic Azad University, Sanandaj, Iran
2- Associate Professor, Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran , fkeshavarzi@iausdj.ac.ir
3- Midwifer, Academic Instrcrutor, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
4- Assistant Professor, Department of Medical Laboratory Sciences, Faculty of Paramedical, Kurdistan University of Medical Sciences, Sanandaj, Iran
5- M.Sc in Medical Mycology, Department of Mycology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract:   (5225 Views)
Background and Objective: Candida species are the second most common cause of vaginitis in worldwide after bacterial agents. This study was performed to determine the etiological factors of Candida vulvovaginitis in pregnant women.
Methods: This descriptive-analytical study, was performed on 100 pregnant women with vaginal discomfort that referring to gynecologic and obstetric clinics of the Sanandaj Social Security Hospital, Kurdistan province, Iran during 2016. After obtaining informed consent and collecting background information using a questionnaire, the patients were examined by a specialist physician and samples were collected. Identification of isolates was done based on colony color and also using PCR-restriction fragment length polymorphism (PCR-RFLP) method.
Results: Candida vulvovaginitis was seen in 29% of women. Candida albicans were the most common cause of the disease (86.2%) followed by Candida paraposilosis (10.43%) and Candida glabrat (45.3%) . There was no significant relationship between diabetes and candida vulvovaginitis. There was a significant relationship between the history of antibiotic usage, age over 35 and third trimester of pregnancy with Candida vulvaginitis (P<0.05).
Conclusion: The prevalence of Candida vulvovaginal candidiasis was 29% and Candida Albicans was the most common cause of the disease.
Keywords: Candida Vulvovaginitis [MeSH], Candida albicans [MeSH], Pregnancy [MeSH], PCR-RFLP [MeSH]
Article ID: Vol22-29
Full-Text [PDF 232 kb]   (10712 Downloads)    
Type of Study: Short Communication | Subject: Obstetrics and Gynecology
References
1. Zisova LG, Chokoeva AA, Amaliev GI, Petleshkova PV, Miteva-Katrandzhieva TМ, Krasteva MB, et al. Vulvovaginal Candidiasis in Pregnant Women and its Importance for Candida Colonization of Newborns. Folia Med (Plovdiv). 2016 Apr-Jun; 58(2): 108-14. DOI: 10.1515/folmed-2016-0018
2. Bitew A, Abebaw Y. Vulvovaginal candidiasis: species distribution of Candida and their antifungal susceptibility pattern. BMC Womens Health. 2018 Jun; 18(1): 94. DOI: 10.1186/s12905-018-0607-z
3. Nyirjesy P, Sobel JD. Vulvovaginal candidiasis. Obstet Gynecol Clin North Am. 2003 Dec; 30(4): 671-84. DOI: 10.1016/s0889-8545(03)00083-4
4. Fidel PL Jr, Cutright J, Steele C. Effects of reproductive hormones on experimental vaginal candidiasis. Infect Immun. 2000 Feb; 68(2): 651-57. DOI: 10.1128/iai.68.2.651-657.2000
5. Bauters TG, Dhont MA, Temmerman MI, Nelis HJ. Prevalence of vulvovaginal candidiasis and susceptibility to fluconazole in women. Am J Obstet Gynecol. 2002; 187(3): 569-74. https://doi.org/10.1067/mob.2002.125897
6. Brandão LDS, Boniek D, Resende Stoianoff MA, da Mata FMR, de Azevedo PRM, Fernandes JV, et al. Prevalence and antifungal susceptibility of Candida species among pregnant women attending a school maternity at Natal, Brazil. Lett Appl Microbiol. 2018 Sep; 67(3): 285-91. DOI: 10.1111/lam.13034
7. Masri SN, Noor SM, Nor LA, Osman M, Rahman MM. Candida isolates from pregnant women and their antifungal susceptibility in a Malaysian tertiary-care hospital. Pak J Med Sci. 2015; 31(3): 658-61. DOI: 10.12669/pjms.313.7072
8. Gonçalves B, Ferreira C, Alves CT, Henriques M, Azeredo J, Silva S. Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors. Crit Rev Microbiol. 2016 Nov; 42(6): 905-27. DOI: 10.3109/1040841X.2015.1091805
9. Sobel JD, Sobel R. Current treatment options for vulvovaginal candidiasis caused by azole-resistant Candida species. Expert Opin Pharmacother. 2018 Jun; 19(9): 971-77. DOI: 10.1080/14656566.2018.1476490
10. Mirhendi H, Makimura K, Khoramizadeh M, Yamaguchi H. A one-enzyme PCR-RFLP assay for identification of six medically important Candida species. Nihon Ishinkin Gakkai Zasshi. 2006; 47(3): 225-29. DOI: 10.3314/jjmm.47.225
11. Mohammadi R, Mirhendi H, Yadegari MH, Shadzi S, Jalalizand N. [Identification and Frequency of Candida Species in Patients with Different Forms of Candidiasis in Isfahan, Using PCR-RFLP Method]. J Isfahan Med Sch. 2011; 29(133): 336-43. [Article in Persian]
12. Kamali Sarwestani Z, Dasdar A, Agha Kuchak Afshari S, Gerami Shoar M, Hashemi S J, Pakzad R, et al. [Evaluation of fungal air contamination in selected wards of two tertiary hospitals in Tehran, Iran]. Tehran Univ Med J. 2017; 75(4): 299-306. [Article in Persian]
13. Farage MA, Miller KW, Sobel JD. Dynamics of the vaginal ecosystem—hormonal influences. Infectious Diseases: Research and Treatment. 2010; 3: 1-15.
14. Larsen B, Monif GR. Understanding the Bacterial Flora of the Female Genital Tract. Clin Infect Dis. 2001 Feb; 32(4): e69-77. DOI: 10.1086/318710
15. Ferrer J. Vaginal candidosis: epidemiological and etiological factors. Int J Gynaecol Obstet. 2000 Dec; 71 (Suppl 1): S21-27. DOI: 10.1016/s0020-7292(00)00350-7
16. Xu J, Schwartz K, Bartoces M, Monsur J, Severson RK, Sobel JD. Effect of antibiotics on vulvovaginal candidiasis: a MetroNet study. J Am Board Fam Med. 2008 Jul-Aug; 21(4): 261-68. DOI: 10.3122/jabfm.2008.04.070169
17. Achkar JM, Fries BC. Candida Infections of the Genitourinary Tract. Clin Microbiol Rev. 2010 Apr; 23(2): 253-73. DOI: 10.1128/CMR.00076-09
18. Mucci MJ, Cuestas ML, Landanburu MF, Mujica MT. Prevalence of Candida albicans, Candida dubliniensis and Candida africana in pregnant women suffering from vulvovaginal candidiasis in Argentina. Rev Iberoam Micol. 2017 Apr-Jun; 34(2): 72-76. DOI: 10.1016/j.riam.2016.09.001
19. Ahmad A, Khan AU. Prevalence of Candida Species and Potential Risk Factors for Vulvovaginal Candidiasis in Aligarh, India. Eur J Obstet Gynecol Reprod Biol. 2009 May; 144(1): 68-71. DOI: 10.1016/j.ejogrb.2008.12.020
20. Hedayati MT, Taheri Z, Galinimoghadam T, Aghili SR, Yazdani Cherati J, Mosayebi E. Isolation of different species of Candida in patients with vulvovaginal candidiasis from sari, iran. Jundishapur J Microbiol. 2015 Apr; 8(4): e15992. DOI: 10.5812/jjm.8(4)2015.15992
21. Trama JP, Adelson ME, Raphaelli I, Stemmer SM, Mordechai E. Detection of Candida species in vaginal samples in a clinical laboratory setting. Infect Dis Obstet Gynecol. 2005 Jun; 13(2): 63-67. DOI: 10.1080/10647440400025629
22. Sobel JD. Vulvovaginal candidosis. Lancet. 2007 Jun; 369(9577): 1961-71. DOI: 10.1016/S0140-6736(07)60917-9
23. Oyewole O, Okoliegbe IN, Alkhalil S, Isah P. Prevalence of vaginal candidiasis among pregnant women attending Federal University of Technology, Minna, Nigeria, Bosso Clinic. Res J Pharm Biol Chem Sci. 2013; 4(1): 113-20.
24. Khan M, Ahmed J, Gul A, Ikram A, Lalani FK. Antifungal susceptibility testing of vulvovaginal Candida species among women attending antenatal clinic in tertiary care hospitals of Peshawar. Infect Drug Resist. 2018 Mar; 11: 447-56. DOI: 10.2147/IDR.S153116
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Mohammadi S, Keshavarzi F, Manouchehri B, Lahoorpour F, Javaheri M R. Etiologic factors of Candida vulvovaginitis in pregnant women. J Gorgan Univ Med Sci 2020; 22 (2) :104-109
URL: http://goums.ac.ir/journal/article-1-3605-en.html


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Volume 22, Issue 2 (6-2020) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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