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:: Volume 10, Issue 2 (6-2008) ::
J Gorgan Univ Med Sci 2008, 10(2): 50-53 Back to browse issues page
The response rate to hepatitis B vaccine in under one-year children in Gorgan, Iran
Abdolvahhab Moradi (PhD) * 1, Behnaz Khodabakhshi (MD) , Ezzatollah Ghaemi (PhD) , Azad Reza Mansourian (PhD) , Abdoljalil Sarikhani (BAc) , Mohsen Saeidi (MSc)
Abstract:   (24252 Views)
Background & Objective: Vaccination is one of the most effective ways in preventing the hepatitis B viruse. This study was done to evaluate the response rate to hepatitis B vaccine in under one-year children in Gorgan, Iran. Materials & Methods: This cross-sectional descriptive study was carried out on 215, children of 7-12 month of age (55.3% male, 44.7% female), in Gorgan, northern Iran during 2006. These subjects already had received the three-time vaccination against hepatitis B. Anti-HBs, Anti-HBc and HBsAg level of these children serum were determined, using ELISA technique. Results: In 30 (14%) subject's serum, there was not detected any antibodies against the viruses. Out of 185 children positive for HBS, 4 cases belong to HBC viruses. As a whole, 86% of the samples, had more than ten international unit of HBS. The meanSD of the titred antibodies in male and female were 158.8412 and 187.5513.83 respectively. The response not to three-times vaccination in male and female were 84% and 89.9% respectively. Conclusion: This study showed that in spit of vaccination, there are cases with virus-contamination. The reasons for absence of any response to the vaccination in some of this children can be due to deficiency in the immune system, improper genetic background which can not be stimulated by that vaccination, inadequate proper conditions for the preservation of vaccine, and the type vaccine used. Also the procedure of vaccine inoculation, the vaccine preservation condition and transportation should be taken into considertion.
Keywords: HBs anti-body, Children, Vaccination, Hepatitis B, Gorgan
Full-Text [PDF 220 kb] [English Abstract]   (18236 Downloads)    
Type of Study: Original Articles | Subject: General
* Corresponding Author Address: Associate Professor, Department of Virology, Gorgan University of Medical Sciences, Gorgan, Iran. abmoradi@yahoo.com

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Abdolvahhab Moradi (PhD), Behnaz Khodabakhshi (MD), Ezzatollah Ghaemi (PhD), Azad Reza Mansourian (PhD), Abdoljalil Sarikhani (BAc), Mohsen Saeidi (MSc). The response rate to hepatitis B vaccine in under one-year children in Gorgan, Iran. J Gorgan Univ Med Sci 2008; 10 (2) :50-53
URL: http://goums.ac.ir/journal/article-1-359-en.html
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Volume 10, Issue 2 (6-2008) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)