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:: Volume 20, Issue 4 (12-2018) ::
J Gorgan Univ Med Sci 2018, 20(4): 16-22 Back to browse issues page
Comparison of the effect of Propofol, Etomidate and Thiopental on Seizure duration following electro convulsion therapy:A clinical trial study
Ramin Amini1 , Sadeghali Taziki2 , Gholamreza Roshandel3 , Kazem Kazemnejad * 4
1- Resident of Anesthesiology, Golestan University of Medical Sciences, Gorgan, Iran. dr.amini.ramin@gmail.com
2- Assistant Professor, Department of Psychiatry, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
3- Assistant Professor, Golestan Research Center of Gastroenterology & Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran
4- Assistant Professor, Department of Anesthesiology, Golestan University of Medical Sciences, Gorgan, Iran , kazemnejad1341@yahoo.com
Abstract:   (10011 Views)
Background and Objective: Electro convulsion therapy (ECT) is one of the most common ways for treatment of psychiatric disorders. The aim of this study was to compare the effect of Propofol, Etomidate, and Thiopental on seizure and recovery duration following ECT.
Methods: In this clinical trial study, 90 patients diagnosed with a psychiatric disorder by a psychiatrist, who need to be treated by ECT in 5 Azar hospital, Gorgan, north Iran. The patients were randomly divided into the three groups by simple random allocation method. Interventions included standard monitoring and pre-oxygenation with 100% FiO2 for 3 minutes for all patients in three groups. Anesthesia of the patients in the first, second, and third group was done with Thiopental (1.5 mg/kg), Propofol (0.6 mg/kg), and Etomidate (0.1 mg/kg), respectively. Administration of Succinyl Colin (0.5 mg/kg) as muscle relaxant and Atropine for prevention of bradycardia was uesd in all patients. Duration of seizure and recovery; changes in hemodynamic status including heart rate (HR) and mean arterial pressure (MAP); and amount of charge for ECT were recorded for each subject.
Results: Mean of seizure duration in Thiopental, Propofol, and Etomidate groups were 43.72±11.81, 35.74±10.58 and 45.81±17.26 seconds, respectively (P<0.05). Amount of charge for ECT in 3 sessions of treatment and changes of HR were not different between the 3 groups. Changes of MAP in the Propofol group was significantly less than other two groups (P<0.05). Recovery time following ECT was the least in Etomidate group in comparison with Thiopental and Propofol (P<0.05).
Conclusion: Ethomidate and Thiopental had the same effect on increasing seizure duration. However, due to the significant reduction in recovery time compared with Thiopental, Ethomidate may be considered as the best choice.
Keywords: Thiopental, Etomidate, Propofol, Electro convulsion therapy, Seizure Duration
Full-Text [PDF 229 kb]   (14078 Downloads)    
Type of Study: Original Articles | Subject: Anesthesiology and Pain
References
1. Bauer J, Hageman I, Dam H, Báez A, Bolwig T, Roed J, et al. Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects. J ECT. 2009 Jun; 25(2): 85-90. doi: 10.1097/YCT.0b013e31818a0203
2. Ayhan Y, Akbulut BB, Karahan S, Gecmez G, Öz G, Gurel SC. Etomidate is associated with longer seizure duration, lower stimulus intensity, and lower number of failed trials in electroconvulsive therapy compared with thiopental. J ECT. 2015 Mar; 31(1): 26-30. doi: 10.1097/YCT.0000000000000149
3. Leiknes KA, Jarosh-von Schweder L, Høie B. Contemporary use and practice of electroconvulsive therapy worldwide. Brain Behav. 2012 May; 2(3): 283-344. doi: 10.1002/brb3.37
4. Kalinowsky LB. History of convulsive therapy. Ann N Y Acad Sci. 1986; 462: 1-4.
5. Endler NS. The origins of electroconvulsive therapy (ECT). Convuls Ther. 1988; 4(1): 5-23.
6. Bini L. Experimental researches on eplieptic attacks induced by the electric current. Am J Psychiatry. 1938; 94(6S): 172-74. https://doi.org/10.1176/ajp.94.6S.172
7. Zaidi NA, Khan FA. Comparison of thiopentone sodium and propofol for electro convulsive therapy (ECT). J Pak Med Assoc. 2000 Feb; 50(2): 60-63.
8. Canbek O, Ipekcıoglu D, Menges OO, Atagun MI, Karamustafalıoglu N, Cetinkaya OZ, et al. Comparison of propofol, etomidate, and thiopental in anesthesia for electroconvulsive therapy: A randomized, double-blind clinical trial. J ECT. 2015 Jun; 31(2):91-97. doi: 10.1097/YCT.0000000000000190
9. Hoyer C, Kranaster L, Janke C, Sartorius A. Impact of the anesthetic agents ketamine, etomidate, thiopental, and propofol on seizure parameters and seizure quality in electroconvulsive therapy: a retrospective study. Eur Arch Psychiatry Clin Neurosci. 2014 Apr; 264(3): 255-61. doi: 10.1007/s00406-013-0420-5
10. Conca A, Germann R, König P. Etomidate vs. thiopentone in electroconvulsive therapy. An interdisciplinary challenge for anesthesiology and psychiatry. Pharmacopsychiatry. 2003 May; 36(3): 94-97. doi: 10.1055/s-2003-39982
11. Zahavi GS, Dannon P. Comparison of anesthetics in electroconvulsive therapy: an effective treatment with the use of propofol, etomidate, and thiopental. Neuropsychiatr Dis Treat. 2014 Feb; 10: 383-89. doi: 10.2147/NDT.S58330
12. Sanacora G, Mason GF, Rothman DL, Hyder F, Ciarcia JJ, Ostroff RB, et al. Increased cortical GABA concentrations in depressed patients receiving ECT. Am J Psychiatry. 2003 Mar; 160(3): 577-79. doi: 10.1176/appi.ajp.160.3.577
13. Arya A, Singh M, Gurwara AK. A comparison of thiopentone sodium, propofol and midazolam for electroconvulsive therapy. J Anaesth Clin Pharmaco. 2008 Jul-Sep; 24(3): 291-94.
14. Ding Z, White PF. Anesthesia for electroconvulsive therapy. Anesth Analg. 2002 May; 94(5): 1351-64.
15. Keith G. Rasmussen. Clinical applications of recent research on electroconvulsive therapy. Bulletin of the Menninger Clinic. 2003 Mar; 67: 18-31. https://doi.org/10.1521/bumc.67.1.18.23449
16. Akhvan Akbari P, Molavi P, Akhvan Akbari G, Ghodrati MR. [Comparing the effects of Propofol and Sodium Thiopental in the induction of anesthesia for electro convulsive therapy (ECT)]. J Ardabil Univ Med Sci. 2009; 9(3): 249-55. [Article in Persian]
17. Abdollahi MH, Izadi A, Hajiesmaeili MR, Ghanizadeh A, Dastjerdi G, Hosseini HA, et al. Effect of etomidate versus thiopental on major depressive disorder in electroconvulsive therapy, a randomized double-blind controlled clinical trial. J ECT. 2012 Mar; 28(1): 10-13. doi: 10.1097/YCT.0b013e31822a6b8e
18. Rasmussen KG, Sampson SM, Rummans TA. Electroconvulsive therapy and newer modalities for the treatment of medication-refractory mental illness. Mayo Clin Proc. 2002 Jun; 77(6): 552-56. doi: 10.4065/77.6.552
19. Rosa MA, Rosa MO, Belegarde IM, Bueno CR, Fregni F. Recovery after ECT: comparison of propofol, etomidate and thiopental. Braz J Psychiatr. 2008 Jun; 30(2): 149-51.
20. Patel AS, Gorst-Unsworth C, Venn RM, Kelley K, Jacob Y. Anesthesia and electroconvulsive therapy: a retrospective study comparing etomidate and propofol. J ECT. 2006 Sep; 22(3): 179-83. doi: 10.1097/01.yct.0000230362.96615.d9
21. Graveland PE, Wierdsma AI, van den Broek WW, Birkenhäger TK. A retrospective comparison of the effects of propofol and etomidate on stimulus variables and efficacy of electroconvulsive therapy in depressed inpatients. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug; 45: 230-35. doi: 10.1016/j.pnpbp.2013.06.003
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Amini R, Taziki S, Roshandel G, Kazemnejad K. Comparison of the effect of Propofol, Etomidate and Thiopental on Seizure duration following electro convulsion therapy:A clinical trial study. J Gorgan Univ Med Sci 2018; 20 (4) :16-22
URL: http://goums.ac.ir/journal/article-1-3535-en.html


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Volume 20, Issue 4 (12-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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